Is virtual colonoscopy a cost-effective option to screen for colorectal cancer?

Sonnenberg, Amnon; Delcò, Fabiola; Bauerfeind, Peter

doi:10.1016/s0002-9270(99)00360-3

Cited by 28 publications

(52 citation statements)

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“…localized, regional, and distant) with those of colonoscopy, all the available simulation models available in the literature (see Table 1) consistently indicate the efficacy of CTC in reducing both CRC incidence and mortality, ranging from 40% to 77% for reduction in CRC incidence (prevention) and from 58% to 84% for CRC mortality reduction. 15–22 Several factors may explain this inter-study variability: The rate of de novo CRC versus benign polyp precursorThe type and prevalence of polyp size classesThe simulated stages of CRCThe rate of progression through the different types of polyps and CRC stagesInput assumptions of CTC accuracyThe impact of extra-colonic findings.…”

Section: Can Ctc Reduce Crc Incidence and Mortality?mentioning

confidence: 99%

“…The available models indicate that CTC is effective in reducing both CRC incidence and mortality, ranging from 40% to 77% for CRC incidence prevention and from 58% to 84% for CRC mortality reduction. 15–22 Several factors may explain this inter-study variability, such as the assumed rate of de novo CRC, the type and prevalence of polyp size classes, the simulated stages of CRC, the progression through the different types of polyps and CRC stages, CTC accuracy, and extra-colonic findings. CTC has been consistently shown to be cost-effective as compared with no screening, indicating that it represents at the very least an attractive test for individuals who are non-compliant with the available options.…”

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confidence: 99%

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Cost-Effectiveness of CT Colonography

Hassan¹,

Pickhardt²

2013

Radiologic Clinics of North America

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Simulation modelling has been extensively applied to CT colonography (CTC) in order to define its long-term efficacy and cost-effectiveness in the setting of colorectal cancer (CRC) screening. The available models indicate that CTC is effective in reducing both CRC incidence and mortality, ranging from 40% to 77% for CRC incidence prevention and from 58% to 84% for CRC mortality reduction.15–22 Several factors may explain this inter-study variability, such as the assumed rate of de novo CRC, the type and prevalence of polyp size classes, the simulated stages of CRC, the progression through the different types of polyps and CRC stages, CTC accuracy, and extra-colonic findings. CTC has been consistently shown to be cost-effective as compared with no screening, indicating that it represents at the very least an attractive test for individuals who are non-compliant with the available options. According to the majority of the simulation models, CTC needs to achieve a higher attendance rate or cost less than colonoscopy in order to be cost-effective relative to colonoscopy.

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Section: Can Ctc Reduce Crc Incidence and Mortality?mentioning

confidence: 99%

mentioning

confidence: 99%

Cost-Effectiveness of CT Colonography

Hassan¹,

Pickhardt²

2013

Radiologic Clinics of North America

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“…Colonoscopy allows inspecting the whole colon and removing detected polyps. However, “the method is time consuming, rather expensive, requires bowel preparation, it is unpleasant for the patients” [30]. Virtual colonoscopy avoids painful bowel preparation performed in conventional colonoscopy.…”

Section: Discussionmentioning

confidence: 99%

Engineering Approach to Identifying Patients with Colon Tumors on the Basis of Electrophotonic Imaging Technique Data

Yakovleva¹,

Korotkov²,

Fedorov³

et al. 2016

TOBEJ

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Background:Colonic neoplasms are quite a serious problem today. Screening methods play an important role in diagnosing the disease. Colorectal cancer screening is a complex undertaking, having various options, which require a lot of efforts both from the doctor and from the patient, including the use of sedatives and the necessity of the presence of an assistant for some procedures such as colonoscopy. This is why it is very important to find a method by which one can make a diagnosis quickly, easily, and painlessly.Methods:The ability to identify patients with tumors of the colon using the Electrophotonic Imaging (EPI) technique, as well as using it for differential diagnosis of tumors of the colon by their morphology, size and quantity was investigated. Selection of the most significant parameters of the EPI-graphy for the separation of the control group and the group of patients with tumors of the colon was developed. 137 people were studied with the EPI camera, with ages ranging from 16 to 86 years, including 49 males and 88 females. Based on the results of the colonoscopy and histological findings all subjects were divided into 2 groups: control group of 55 people, 9 males, 46 females; and patients with tumors (benign or malignant) of the colon - 82 people; 40 males and 42 females. Then all subjects were divided into smaller groups based on morphology, size, number of tumors and localization.Results:Based on the identified indicators decision rules to determine the patients with tumors of the colon were constructed. The specificity of the resulting function was 80.0% and sensitivity 75.6%. Decision rule was built as well with logistic regression. The specificity of the resulting function was 78.2% and sensitivity 90.0%. The accuracy of this approach was higher than using discriminant analysis.Conclusions:The results of this study have proven the ability to identify patients with tumors of the colon using EPI technology, as well as use it for differential diagnosis of tumors of the colon by their morphology, size and quantity. EPI testing is non-invasive, takes less than five minutes, and equipment is relatively cheap and accessible in mass production. This opens up good prospects for further research for implementation as a first step of the screening process. This paper presents the pilot study developing methodological approach to the GDV data processing. That is why we tried different methods of data processing. At the same time we do not pretend to develop a diagnostic method – sample size is too small for this, and other cancer types were not studied. Further research is needed.

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“…Early cost-effectiveness analyses from the US concluded that a screening strategy employing CT colonography is more costly than one using colonoscopy every 10 years 70 71. These analyses used outdated CTC performance characteristics or a fixed screening interval of 10 years.…”

Section: Cost-effectivenessmentioning

confidence: 99%

Role of CT colonography in colorectal cancer screening: risks and benefits

Pox

Schmiegel

2010

Gut

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The purpose of this article is to review recent developments in the role of CT colonography with an emphasis on colorectal cancer screening. An introduction to the concept and method of CT colonography is given as well as a summary of the data on performance of CT colonography. Furthermore, details on side effects, efficacy and cost-effectiveness and the possible role of extracolonic findings are provided. The impact CTC could have on colonoscopy and other possible indications of the method are also mentioned.

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Is virtual colonoscopy a cost-effective option to screen for colorectal cancer?

Abstract: To become cost-effective and be able to compete with colonoscopy in screening for colorectal cancer, CT or MR colonography would need be offered at a very low price or result in compliance rates much better than those associated with colonoscopy.

Cited by 28 publications

References 0 publications

Cost-Effectiveness of CT Colonography

Cost-Effectiveness of CT Colonography

Engineering Approach to Identifying Patients with Colon Tumors on the Basis of Electrophotonic Imaging Technique Data

Role of CT colonography in colorectal cancer screening: risks and benefits

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