Is vascular calcification associated with bone mineral density and osteoporotic fractures in ambulatory, elderly women?

Flipon, Elisabeth; Liabeuf, Sophie; Fardellone, Patrice; Mentaverri, Romuald; Ryckelynck, T.; Grados, Franck; Kamel, Saı̈d; Massy, Ziad A.; Dargent-Molina, Patricia; Brazier, Michel

doi:10.1007/s00198-011-1762-3

Cited by 27 publications

(19 citation statements)

References 20 publications

(27 reference statements)

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“…In 340 women, severe mitral annular calcification was associated with higher prevalence of osteoporosis diagnosed by DXA (40). By contrast, several studies show that, after adjustment for age and other confounders, the association between BMD and coronary artery calcification is not significant (27,35,41,42).…”

Section: Vascular Calcification and Fracture Riskmentioning

confidence: 94%

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Vascular calcification and fracture risk

Szulc

2015

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SummaryOsteoporosis and cardiovascular diseases are public health problems. Fragility fractures are associated with high risk of cardiovascular event and patients with cardiovascular diseases have higher risk of fracture. Severe abdominal aortic calcification (AAC) is associated with higher cardiovascular mortality and morbidity. Severe AAC is associated with higher risk of fracture. In cross-sectional studies severe AAC was associated with greater prevalence, higher number and greater severity of vertebral fractures after adjustment for confounders including bone mineral density (BMD). Prospective studies confirm the association between baseline AAC severity and prospectively assessed fracture risk in both sexes. Data on the link between AAC and BMD are discordant. Age, smoking, hypertension, diabetes mellitus, and low grade systemic inflammation are possible risk factors of severe AAC and fracture risk. However, in clinical studies, the link between AAC and fracture was significant after adjustment for these factors. Data on the association between calcification in other vascular beds and BMD are limited and discordant.

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Section: Vascular Calcification and Fracture Riskmentioning

confidence: 94%

“…Aortic calcification is a dynamic process and its severity at a given moment may not predict its long term progression (32,33). Wang et al and Flipon et al found no association between AAC and risk of non-vertebral fracture in elderly women (34,35). However, AAC threshold was low.…”

Section: Vascular Calcification and Fracture Riskmentioning

confidence: 97%

Vascular calcification and fracture risk

Szulc

2015

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“…While some of them have reported an increased fracture risk with increased vascular calcification [14,17], other studies have not found such results [11,18].…”

Section: Introductionmentioning

confidence: 97%

“…It has motivated several investigators to evaluate whether bone mineral density (BMD) and vascular calcification (VC) in several vascular beds are associated beyond the aging process and independent of potential confounders [8e14]. Among studies with a cross-sectional design, an inverse relation between aortic or coronary artery calcification (CAC) and BMD has been reported by some [8,9] but not others [10,11]. In contrast, longitudinal studies have consistently shown that increased BMD loss is associated with increased aortic vascular calcification assessed through different imaging modalities, such as X-rays and radiogrammetry [12,13] as well as through computed tomography [14], this relation has not been explained by aging and other shared risk factors and has been found mainly in women.…”

Section: Introductionmentioning

confidence: 99%

Bone health and coronary artery calcification: The Rotterdam Study

et al. 2015

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“…However, the adjustment for the measures of general health and frailty had a limited impact on these associations. Some, 1,4,5 but not all, 2,29,30 prospective studies showed that severe AAC is associated with higher risk of fragility fracture. This association was found both in men and in women, for various types of fracture (hip, vertebra, all osteoporotic fractures) and remained significant after adjustment for BMD.…”

Section: Association Between the Prevalent Cardiovascular Pathology Amentioning

confidence: 99%

Association between cardiovascular diseases and osteoporosis—reappraisal

Szulc

2012

BoneKEy Reports

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Many studies published over the past 20 years show a significant positive association between cardiovascular diseases (CVD) and osteoporosis. This association is important because it concerns two major public health problems. The investigation of shared biomarkers (clinical, radiological, biochemical) may improve identification of subjects at high risk of both diseases. The investigation of shared pathophysiological mechanisms may help to understand the pathophysiology of these diseases and to establish new treatments that could be efficient in both diseases. Below, I have tried to analyze various groups of clinical studies to better understand the association between osteoporosis and CVD as well as discrepancies between the studies. My review is focused on the epidemiological studies of the general population, and I have not analyzed the association between bone and CVD in chronic renal failure. Association between Cardiovascular Diseases and Bone Mineral DensitySeveral studies showed that CVD and arterial calcification are associated with decreased bone mineral density (BMD), although findings vary according to skeletal site and gender. Severe abdominal aortic calcification (AAC) was associated with lower BMD at the spine and hip in older women, 1 at the hip and whole body (but not spine) in older women (but not men), 2 at the lumbar spine (but not femoral neck) in a cohort of men and women, 3 at the femoral neck in women 4 and at whole body and distal forearm (but not at the spine or hip) in older men. 5 Severe AAC was associated with lower trabecular volumetric BMD at the spine in postmenopausal women, 6 in peri-and postmenopausal black and white women, 7 and in men and women aged у 45 years. 8 In a group of siblings concordant for type 2 diabetes, severity of the coronary and aortic calcification was correlated negatively with spine volumetric BMD. 9 In other studies, the association between AAC severity and BMD was weak or non-significant. 10 -13 Limited data also suggest a weak but significant association between severe peripheral arterial disease (PAD) and lower BMD at the hip. 14 -16 Elevated diastolic (but not systolic) blood pressure was associated with lower BMD at the total body, trochanter and Ward ' s triangle in a small group of 47 men aged 24 to 77 years. 17 REVIEW Association between cardiovascular diseases and osteoporosis -reappraisal Pawel SzulcINSERM UMR 1033, Universit é de Lyon, H ô pital Edouard Herriot , Lyon , France .Positive association between cardiovascular diseases and osteoporosis is important because it concerns two major public health problems. Men and women with cardiovascular diseases (including severe abdominal aortic calcification (AAC) and peripheral arterial disease) tend to have lower areal and volumetric bone mineral density (BMD) as well as faster bone loss, although findings vary according to skeletal site. On one hand, severe forms of cardiovascular diseases (heart failure, myocardial infarction, hypertension, severe AAC) are associated with higher risk of osteop...

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Is vascular calcification associated with bone mineral density and osteoporotic fractures in ambulatory, elderly women?

Abstract: Osteoporosis and aortic calcification appear to be independent processes in a cohort of ambulatory, elderly women. However, potential confounding factors may be present and prospective studies are needed to investigate this situation further.

Cited by 27 publications

References 20 publications

Vascular calcification and fracture risk

Vascular calcification and fracture risk

Bone health and coronary artery calcification: The Rotterdam Study

Association between cardiovascular diseases and osteoporosis—reappraisal

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