Is Urolithiasis Associated with Increased Levels of High Sensitivity C-Reactive Protein and Interleukin-6 in Diabetic Patients?

Hasna, Aysha; Meiyappan, Kavitha; Periyasam, Senthilkumar Gandhipuram; Muruganandham, K; Bobby, Zachariah; Subramaniam, Arul Vijaya Vani

doi:10.7860/jcdr/2015/12489.5681

Cited by 10 publications

(13 citation statements)

References 32 publications

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“…Increased levels of VDR protein in the kidney are regarded as a common feature in both GHS rats and IH individuals ( Frick, Krieger & Bushinsky, 2015 ), and VDR intimately affects urolithiasis formation ( Arcidiacono et al, 2014 ; Zhang, Nie & Jiang, 2013 ). Glybochko et al (2010) found a significant increase in serum IL-6 in nephrolithiasis patients compared with healthy individuals, and Hasna et al (2015) showed that IL-6 was significantly increased in patients with diabetes mellitus and urolithiasis compared with patients with diabetes mellitus alone. In addition, skeletal system development (GO:0001501) and skeletal system morphogenesis (GO:0048705) were significantly increased in GHS rats.…”

Section: Discussionmentioning

confidence: 99%

Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney

Qin

et al. 2016

PeerJ

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Background. MicroRNAs (miRNAs) influence a variety of biological functions by regulating gene expression post-transcriptionally. Aberrant miRNA expression has been associated with many human diseases. Urolithiasis is a common disease, and idiopathic hypercalciuria (IH) is an important risk factor for calcium urolithiasis. However, miRNA expression patterns and their biological functions in urolithiasis remain unknown.Methods and Results. A multi-step approach combining microarray miRNA and mRNA expression profile and bioinformatics analysis was adopted to analyze dysregulated miRNAs and genes in genetic hypercalciuric stone-forming (GHS) rat kidneys, using normal Sprague-Dawley (SD) rats as controls. We identified 2418 mRNAs and 19 miRNAs as significantly differentially expressed, over 700 gene ontology (GO) terms and 83 KEGG pathways that were significantly enriched in GHS rats. In addition, we constructed an miRNA-gene network that suggested that rno-miR-674-5p, rno-miR-672-5p, rno-miR-138-5p and rno-miR-21-3p may play important roles in the regulatory network. Furthermore, signal-net analysis suggested that NF-kappa B likely plays a crucial role in hypercalciuria urolithiasis.Conclusions. This study presents a global view of mRNA and miRNA expression in GHS rat kidneys, and suggests that miRNAs may be important in the regulation of hypercalciuria. The data provide valuable insights for future research, which should aim at validating the role of the genes featured here in the pathophysiology of hypercalciuria.

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Section: Discussionmentioning

confidence: 99%

Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney

Qin

et al. 2016

PeerJ

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“…Increased levels of VDR protein in the kidney are regarded as a common feature in both GHS rats and IH individuals (Frick et al 2015), and VDR intimately affects urolithiasis formation (Arcidiacono et al 2014;Zhang et al 2013). Glybochko et al found a significant increase in serum IL-6 in nephrolithiasis patients compared with healthy individuals (Glybochko et al 2010), and Hasna et al showed that IL-6 was significantly increased in patients with diabetes mellitus and urolithiasis compared with patients with diabetes mellitus alone (Hasna et al 2015). In Manuscript to be reviewed addition, skeletal system development (GO: 0001501) and skeletal system morphogenesis (GO: 0048705) were significantly increased in GHS rats.…”

Section: Discussionmentioning

confidence: 99%

Peer Review #3 of "Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney (v0.1)"

2016

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Background. MicroRNAs (miRNAs) influence a variety of biological functions by regulating gene expression post-transcriptionally. Aberrant miRNA expression has been associated with many human diseases. Urolithiasis is a common disease, and idiopathic hypercalciuria (IH) is an important risk factor for calcium urolithiasis. However, miRNA expression patterns and their biological functions in urolithiasis remain unknown. Methods and Results. A multi-step approach combining microarray miRNA and mRNA expression profile and bioinformatics analysis was adopted to analyze dysregulated miRNAs and genes in genetic hypercalciuric stone-forming (GHS) rat kidneys, using normal Sprague-Dawley (SD) rats as controls. We identified 2418 mRNAs and 19 miRNAs as significantly differentially expressed, over 700 Gene Ontology (GO) terms and 83 KEGG pathways that were significantly enriched in GHS rats. In addition, we constructed an miRNA-gene network that suggested that rno-miR-674-5p, rno-miR-672-5p, rno-miR-138-5p and rno-miR-21-3p may play important roles in the regulatory network. Furthermore, signal-net analysis suggested that NF-kappa B likely plays a crucial role in hypercalciuria urolithiasis. Conclusions. This study presents a global view of mRNA and miRNA expression in GHS rat kidneys, and suggests that miRNAs may be important in the regulation of hypercalciuria. The data provide valuable insights for future research, which should aim at validating the role of the genes featured here in the pathophysiology of hypercalciuria.

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“…Moreover, a renal biopsy from kidneys containing calculi showed increased mRNA expression of IL-6 and MCP-1 in kidney tissue [83]. Additionally, Hasna and colleagues (2015) found that diabetic patients with urolithiasis were characterised by higher CRP and IL-6 levels than diabetes mellitus cases without urolithiasis [84]. The increased level of serum CRP correlated with self-reported kidney stone incidences in younger individuals [85].…”

Section: Inflammationmentioning

confidence: 99%

The Molecular Aspect of Nephrolithiasis Development

Wigner

Grębowski

Bijak

et al. 2021

Cells

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Urolithiasis is the third most common urological disease after urinary tract infections and prostate diseases, and it is characterised by an occurrence rate of about 15%, which continues to rise. The increase in the incidence of kidney stones observed in recent decades, is most likely caused by modifications in dietary habits (high content of protein, sodium and sugar diet) and lifestyle (reduced physical activity) in all industrialised countries. Moreover, men are more likely than women to be diagnosed with kidney stones. A growing body of evidence suggests that inflammation, oxidant–antioxidant imbalance, angiogenesis, purine metabolism and urea cycle disorders may play a crucial role in nephrolithiasis development. Patients with urolithiasis were characterised by an increased level of reactive oxygen species (ROS), the products of lipid peroxidation, proinflammatory cytokines as well as proangiogenic factors, compared to controls. Furthermore, it has been shown that deficiency and disorders of enzymes involved in purine metabolism and the urea cycle might be causes of deposit formation. ROS generation suggests that the course of kidney stones might be additionally potentiated by inflammation, purine metabolism and the urea cycle. On the other hand, ROS overproduction may induce activation of angiogenesis, and thus, allows deposit aggregation.

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Is Urolithiasis Associated with Increased Levels of High Sensitivity C-Reactive Protein and Interleukin-6 in Diabetic Patients?

Cited by 10 publications

References 32 publications

Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney

Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney

Peer Review #3 of "Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney (v0.1)"

The Molecular Aspect of Nephrolithiasis Development

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