Is Uric Acid a Predictive Factor for Graft Dysfunction in Renal Transplant Recipients?

Akgul, A.; Bilgic, Ayse; Ibis, A.; Özdemir, F.N.; Arat, Z.; Haberal, Mehmet

doi:10.1016/j.transproceed.2007.03.028

Cited by 43 publications

(44 citation statements)

References 12 publications

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“…The influence of hyperuricemia on renal allograft functioning remains controversial. Akgül and associates 4 reported that high UA levels do not have a role on developing chronic allograft nephropathy during the first 3 years after transplant. Gerhardt and associates 12 reported significantly reduced transplant survival rates among hyperuricemic patients compared with those who were normouricemic kidney transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

“…Also, diuretic therapy, graft dysfunction, and obesity may cause hyperuricemia in renal transplant recipients. 4 In several studies with adult renal transplant recipients, it has been reported that hyperuricemia may contribute significantly to reduced kidney transplant survival. 5 However, the data are scarce on hyperuricemia in pediatric kidney transplant recipients.…”

Section: Introductionmentioning

confidence: 99%

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Hyperuricemia in Pediatric Renal Transplant Recipients

Gökçeoğlu

Akman²,

Koyun³

et al. 2013

Exp Clin Transplant

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Objectives: We sought to evaluate the prevalence and confounding clinical variables of hyperuricemia in pediatric kidney transplant patients. Materials and Methods:We retrospectively evaluated the medical records of 151 pediatric renal transplant recipients who received their grafts at Akdeniz University Medical Faculty in Antalya, Turkey, with a follow-up longer than 6 months. This retrospective, single-center study included 117 pediatric renal transplant recipients, after we had excluded the patients with changes in immunosuppressive treatment and graft loss, who were receiving therapy with allopurinol and furosemide. Patient information and laboratory data were obtained from patient charts and an electronic hospital database. Results: Mean uric acid levels of patients were 311 ± 74 μmol/L, and 24 of all of the patients (20%) had high uric acid levels. Fifteen patients taking tacrolimus (16%), and 9 of patients taking cyclosporine (39%) had hyperuricemia. The hyperuricemia rate of patients taking cyclosporine was significantly higher than it was for those patients taking tacrolimus (P = .014). Mean levels of uric acid in patients taking cyclosporine were higher than those of patients taking tacrolimus (344 ± 62 µmol/L and 303 ± 75 μmol/L; P = .006). There was a significant positive correlation between mean uric acid concentrations, and both serum creatinine (P = .000; r=0.487) and cystatin C (P = .000; r=0.433). There was negative correlation between mean uric acid concentration and estimated glomerular filtration rate (P = .000; r=-0.417). Mean uric acid levels of patients with intact graft function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m 2 ) was lower than the patients with a low estimated glomerular filtration rate (291 ± 67 μmol/L and 353 ± 71 μmol/L; P = .000). Mean uric acid level of patients with normal body mass index was significantly lower than that of patients who were obese-overweight (301 ± 64 μmol/L vs 343 ± 94 μmol/L; P = .045). Conclusions: We found 20% of our patient group had high uric acid levels. We also found that lower glomerular filtration rate, higher serum creatinine, cystatin c, obesity, and being overweight were risk factors for hyperuricemia in pediatric renal transplant recipients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperuricemia in Pediatric Renal Transplant Recipients

Gökçeoğlu

Akman²,

Koyun³

et al. 2013

Exp Clin Transplant

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“…134,135 The impact of HUA on graft survival is controversial. Some studies indicate that HUA is only a marker of graft dysfunction, [136][137][138][139] whereas some other studies suggest that UA is an independent risk factor for graft dysfunction. [140][141][142][143][144][145][146] Recently, Hart et al 147 reported that HUA correlated with tubular atrophy and interstitial fibrosis in chronic allograft nephropathy.…”

Section: Hua and Renal Transplantationmentioning

confidence: 99%

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

et al. 2014

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The role of uric acid (UA) on the pathogenesis and progression of chronic kidney disease (CKD) remains controversial. Experimental and clinical studies indicate that UA is associated with several risk factors of CKD including diabetes, hypertension, oxidative stress, and inflammation and hyperuricemia could be considered as a common dominator linking CKD and cardiovascular disease. Notably, the impact of serum UA levels on the survival of CKD, dialysis patients, and renal transplant recipients is also a matter of debate, as there are conflicting results from clinical studies. At present, there is no definite data whether UA is causal, compensatory, coincidental or it is only an epiphenomenon in these patients. In this article, we attempt to review and elucidate the dark side of this old molecule in CKD and renal transplantation.

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“…They also require additional medication such as iron supplements, phosphate binders, and antihypertensive drugs. Despite the advent of dialysis, most people with advanced kidney failure die within 5 to 10 years [16][17][18][19][20][21].…”

Section: Determination and Modelling Of Clinical Laboratory Data Of Hmentioning

confidence: 99%

Determination and modelling of clinical laboratory data of healthy individuals and patients with end-stage renal failure

et al. 2009

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AbstractThe analyses of 18 biochemical parameters (alanine aminotransferase, albumin, aspartate aminotransferase, calcium, cholesterol, chloride, creatinine, iron, glucose, γ- glutamyl transferase, alkaline phosphatase, phosphorus, potassium, sodium, total protein, triglycerides, uric acid, and urea nitrogen) were performed for 166 healthy individuals and 108 patients with end-stage renal failure (ESRF). The application of cluster analysis proved that there were points of similarity among all 18 biochemical parameters that formed major groups; these groups corresponded to the authors’ assumption of the existence of several overall patterns of biochemical parameters that may be termed “enzyme-specific”; “general health indicator”; “major component excretion”; “blood-specific indicator”; and “protein-specific”. These patterns also appear in the subsets of males and females that were obtained by separation of the general dataset. In addition, the performance of factor analysis similarly proved the validity of this assumption. This projection and modelling method indicated the existence of seven latent factors, which explained 70.05% of the total variance in the system for healthy individuals and more than 72% of the total variance in the system for patients with ESRF. All these results support the probability that a general health indicator could be constructed by taking into account the existing classification groups in the list of biochemical parameters.

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Is Uric Acid a Predictive Factor for Graft Dysfunction in Renal Transplant Recipients?

Cited by 43 publications

References 12 publications

Hyperuricemia in Pediatric Renal Transplant Recipients

Hyperuricemia in Pediatric Renal Transplant Recipients

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

Determination and modelling of clinical laboratory data of healthy individuals and patients with end-stage renal failure

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