Is transient hypogammaglobulinemia of infancy a manifestation of zinc deficiency?

Lentz, Delphine; Gershwin, M. Eric

doi:10.1016/0145-305x(84)90003-x

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…For example, while the low IgG level occurs at a relatively benign point in the maturation of human infants, it coincides with the onset of weaning in monkey infants and may contribute to a heightened disease susceptibility at this time. Even in human infants, unusually low levels of IgG may be associated with a higher incidence of bacterial infection at 3-6 months of age (i.e., transient hypogammaglobulinemia, Hosking & Roberton, 1983;Lentz & Gershwin, 1984).…”

Section: Overall Discussionmentioning

confidence: 99%

Effects of age, sex, and psychological disturbance on immunoglobulin levels in the squirrel monkey

Coe

Cassayre

Levine

et al. 1988

Developmental Psychobiology

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The following research assessed the influence of developmental, hormonal, and psychological factors on immunoglobulin and complement protein levels in the squirrel monkey. A cross-sectional life span study established that the developmental pattern of immunoglobulins and complement proteins was similar to that observed in humans. IgG and IgM levels rose progressively with age, while the complement system was mature at birth. In contrast to humans, this species showed a significant sex difference in IgG levels, with higher levels in males during both infancy and adulthood. Males also showed a greater antibody response to viral challenge than did females, and evaluation of gonadectomized subjects suggested that the sex difference in antibody production was testosterone-dependent. The effect of acute and sustained psychological disturbance on IgG levels was also evaluated in infant monkeys. Repeated, brief separations from the mother did not alter IgG levels, but IgG levels were suppressed after a 7-day removal from the mother. Therefore, despite the general view that immunoglobulin levels are relatively stable, these studies have established that immunoglobulin levels can be strongly influenced by hormonal and experiential factors in the squirrel monkey.

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Section: Overall Discussionmentioning

confidence: 99%

Effects of age, sex, and psychological disturbance on immunoglobulin levels in the squirrel monkey

Coe

Cassayre

Levine

et al. 1988

Developmental Psychobiology

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“…Stimulation of the THI B cells in vitro with Epstein-Barr virus, a T-independent B cell stimulator, resulted in normal immunoglobulin production, indicating that the B cells were intrinsically normal. 11 A paper by Lentz and Gershwin proposed the hypothesis, based on studies in mice, that maternal zinc deficiency during pregnancy, might explain the transient helper T cell function noted by Siegel et al 40 Other investigators have not been able to confirm the finding of decreased numbers of CD41 cells, however, and the studies of T cell help have not been reproduced. The hypothesis of zinc deficiency during pregnancy has not been evaluated in humans.…”

Section: T Cell Abnormalitiesmentioning

confidence: 95%

Transient Hypogammaglobulinemia of Infancy

McGeady

2014

Stiehm's Immune Deficiencies

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Effects of age, rearing, and separation stress on immunoglobulin levels in rhesus monkeys

Scanlan

Coe

Latts

et al. 1987

American J Primatol

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The study reported here examined the effect of different rearing conditions and psychological stress on immunoglobulin levels in rhesus monkey infants. In the first experiment, 24 rhesus neonates were placed in one of the three following rearing conditions: Separated from their mothers and reared in the laboratory nursery; kept with their biological mothers; or removed at birth from their biological mothers and cross-fostered to adoptive rhesus mothers. Plasma samples were obtained from the nursery-reared infants immediately after birth and at weekly intervals for the next 30 days. Samples were also obtained from mother-reared and foster-reared infants on days 15 and 29. All samples were tested for IgG and IgM levels. The results indicated that neither rearing nor diet affected Ig levels. IgG levels were highest at birth and decreased progressively for the first 30 days, suggesting that placental transfer of maternal IgG is the critical determinant of IgG levels in primate infants as in humans. IgM changes were also similar to those in human infants: Low levels at birth, a significant increase from birth to day 15, and a moderate decline from day 15 to day 30. When IgG levels and IgM levels were correlated across the first month, many significant correlations were found which were consistent with human data relating both infant IgG and IgM levels to infant maturation. In the second experiment, 11 of the previously tested nursery infants were subjected to four consecutive social separations from peer groups at 6 months of age. Plasma samples were obtained before and after the first and fourth weeks of separation and tested for IgG and IgM levels. Small but significant decreases in both immunoglobulins were detected after 4 days of separation, particularly on the fourth week.

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Is transient hypogammaglobulinemia of infancy a manifestation of zinc deficiency?

Cited by 5 publications

References 23 publications

Effects of age, sex, and psychological disturbance on immunoglobulin levels in the squirrel monkey

Effects of age, sex, and psychological disturbance on immunoglobulin levels in the squirrel monkey

Transient Hypogammaglobulinemia of Infancy

Effects of age, rearing, and separation stress on immunoglobulin levels in rhesus monkeys

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