Is topical alprostadil an usable and reliable alternative to intracavernous injection for penile dynamic duplex ultrasonography?

Abstract

No study has yet been done to evaluate topical alprostadil as a less invasive alternative vasoactive agent for Penile Dynamic Duplex Ultrasonography (PDDU) in the diagnosis of erectile dysfunction. The main aim of our study was to evaluate the usability and reliability of topical alprostadil for PDDU compared with standard intracavernous injection. A further objective was to determine the patients' preference between these two different approaches. During session A, patients received injection while during session B, they received topical alprostadil. Each patient underwent both sessions, 1 week apart from the other. A total of 80 patients were enrolled. After 20 min from drug administration, no significant difference was found between the two procedures in terms of peak systolic velocity and end‐diastolic velocity, while Erection Hardness Score was significantly higher with injection. Patients reported less pain/discomfort during the procedure in case of topical alprostadil use and an overall preference towards this examination modality. Topical alprostadil could represent a usable and reliable alternative to intracavernous injection for PDDU, with less discomfort and greater preference by patients.

Voice Assistants as Consultants for Male Patients with Sexual Dysfunction: A Reliable Option?

“…ED [14][15][16][17][18][19][20], PE [21], PD [22][23][24][25][26][27][28][29][30], male infertility [31,32], genital aesthetic concerns [33][34][35][36][37], as well as several other conditions [38][39][40][41][42][43][44][45] can significantly impact the sexual health of male patients. When this happens, worries and doubts often lead patients to independently search for information on the Internet with every available tool [1,2].…”

Value of transrectal color Doppler ultrasound of the common penile arteries in the diagnosis of arteriogenic erectile dysfunction: A pilot study

“…Actually, the main non-invasive tool is the flaccid penile doppler ultrasound, which is indicated by EAU Guidelines only in selected patients with ED, 6 even if the use of topical alprostadil could represent a usable and reliable alternative to intra-cavernous injection for the penile ultrasound. 13 Moreover, its diagnostic performance is unclear, as it has high variability in data expression and interpretation, due to the lack of uniform standard operating procedures. 14 Furthermore, hemodynamic parameters have significant variations depending on whether the measurement is performed from the crura to the coronal sulcus of the penis and the optimal cut-off points of flaccid PSV is controversial.…”