Is TNF-α gene polymorphism related to pulmonary functions and prognosis as determined by FEV1, BMI, COPD exacerbation and hospitalization in patients with smoking-related COPD in a Turkish population?

Ozdogan, Nezihe; Tutar, Nuri; Demir, Ramazan; Saatci, Cetin; Kanbay, Asiye; Büyükoğlan, Hakan

doi:10.1016/j.rppneu.2014.03.003

Cited by 9 publications

(2 citation statements)

References 38 publications

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“…In a Turkish population, rs1800629 was not found to be associated with the GOLD grade; however, the GA genotype was associated with exacerbations and hospitalizations. 32 In another study performed in the population of Helsinki, the GA genotype of the same polymorphism was associated with paraseptal emphysema, which is a COPD clinical phenotype. 25 …”

Section: Discussionmentioning

confidence: 98%

<em>TNF</em> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning

Reséndiz-Hernández

Ambrocio-Ortiz

Pérez-Rubio

et al. 2018

COPD

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BackgroundSmoking and smoke from biomass burning (BB) are the main environmental risk factors for COPD. Clinical differences have been described between COPD related to smoking and related to wood smoke, but no studies have shown genetic differences between patients exposed to these two risk factors.MethodsTo investigate a possible association of tumor necrosis factor (TNF) promoter polymorphisms, we conducted a case–control study. A total of 1,322 subjects were included in four groups: patients with a diagnosis of COPD secondary to smoking (COPD-S, n=384), patients with COPD secondary to biomass burning (COPD-BB, n=168), smokers without COPD (SWOC, n=674), and biomass burning-exposed subjects (BBES n=96). Additionally, a group of 950 Mexican mestizos (MMs) was included as a population control. Three single nucleotide polymorphisms (SNPs) were selected in the TNF gene (rs1800629, rs361525, and rs1800750) and one SNP in the lymphotoxin alpha gene (rs909253).ResultsStatistically significant differences were found with genotype GA of the rs1800629: COPD-S vs SWOC, (p<0.001, odds ratio [OR] =2.55, 95% CI=1.53–4.27); COPD-S vs COPD-BB (p,0.01). When performing the comparison of the less severe (G1: I + II) and the more severe (G2: III + IV) levels, differences were identified in G1 (p<0.05, OR=1.94, 95% CI=1.04–3.63) and G2 (p<0.001, OR=3.68, 95% CI=1.94–3.07) compared with SWOC. Regarding genotype GA of rs361525, it has been associated when comparing COPD-BB vs BBES (p=0.0079, OR=5.99, 95% CI=1.38–53.98).ConclusionThe heterozygous genotype GA of polymorphisms rs1800629 and rs361525 in the TNF promoter are associated with the risk of COPD.

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Section: Discussionmentioning

confidence: 98%

<em>TNF</em> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning

Reséndiz-Hernández

Ambrocio-Ortiz

Pérez-Rubio

et al. 2018

COPD

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“… 30 Consistent with this finding, in a Caucasian population in Turkey, no association was found between rs1800629 and the prognosis, as determined by the decrease in FEV 1 and body mass index in the monitoring of patients after 1 year; however, genotype GA showed an association with exacerbations and hospitalization. 31 Interestingly, in Span-ish Caucasians, allele A of TNF -863 was associated with an improved FEV 1 and a low-BODE (Body mass index, Obstruction, Dyspnea, Exercise capacity) index. 32 Similar to these findings, in a study conducted in ten different centers in the US, considering ten SNPs in LTA and four in TNF , no association was found with clinical severity variables.…”

Section: Discussionmentioning

confidence: 98%

Identification of genetic variants in the TNF promoter associated with COPD secondary to tobacco smoking and its severity

Reséndiz-Hernández¹,

Sansores²,

Hernández-Zenteno³

et al. 2015

COPD

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Chronic obstructive pulmonary disease (COPD) is an inflammatory disease that arises in response to noxious particles or gases. Associations of genetic polymorphisms in TNF have been reported in Asians and Caucasians, but not in Mestizo populations. A case-control study was conducted in two stages: in the first stage, patients with COPD (COPD group, n=165) and smokers without disease (SNC group, n=165) were included and the TNF promoter sequence was determined using direct sequencing. In the second stage, the identified polymorphisms were validated by real-time polymerase chain reaction (PCR) in COPD (n=260) and SNC (n=506). In the first stage, 11 different sets of “contig” alignments were determined, of which contig 10 was found to be associated with susceptibility (P=5.0E-04, OR [odds ratio] =3.64) and contig 1 with Global Initiative for COPD (GOLD) greater grade (P=1.0E-02, OR =3.82). The single nucleotide polymorphisms found in this region were individually identified; the GA genotypes of rs1800629 (P=0.038, OR =2.07), rs56036015 (P=0.0082, OR =3.18), and rs361525 (P=1.0E-02, OR =4.220) were higher in the COPD group vs the SNC group; after second-stage validation, rs1800629 (P=6.00E-03, OR =2.26) and rs56036015 (P=1.10E-03, OR =2.54) are maintained. There are genetic variants in the TNF promoter associated with increased risk of COPD secondary to smoking and with a higher GOLD grade in the Mexican Mestizo population.

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TNF-α −308 G/A variant and susceptibility to chronic obstructive pulmonary disease: A systematic review and meta-analysis

et al. 2019

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Is TNF-α gene polymorphism related to pulmonary functions and prognosis as determined by FEV1, BMI, COPD exacerbation and hospitalization in patients with smoking-related COPD in a Turkish population?

Cited by 9 publications

References 38 publications

<em>TNF</em> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning

<em>TNF</em> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning

Identification of genetic variants in the TNF promoter associated with COPD secondary to tobacco smoking and its severity

TNF-α −308 G/A variant and susceptibility to chronic obstructive pulmonary disease: A systematic review and meta-analysis

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Is TNF-α gene polymorphism related to pulmonary functions and prognosis as determined by FEV1, BMI, COPD exacerbation and hospitalization in patients with smoking-related COPD in a Turkish population?

Cited by 9 publications

References 38 publications

<em>TNF</em> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning

<em>TNF</em> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning

Identification of genetic variants in the TNF promoter associated with COPD secondary to&nbsp;tobacco smoking and its severity

TNF-α −308 G/A variant and susceptibility to chronic obstructive pulmonary disease: A systematic review and meta-analysis

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Identification of genetic variants in the TNF promoter associated with COPD secondary to tobacco smoking and its severity