Is there unmet need for implantable cardioverter defibrillators? Findings from a post-mortem series of sudden cardiac death

Chase, Deborah; Roderick, Paul; Burnley, H.; Gallagher, Patrick J.; Roberts, Paul R.; Morgan, John M.

doi:10.1093/europace/eun114

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…To our knowledge, the present study is the first report The present study revealed that the incidence of SCD due to cardiomyopathies in Egypt is within the range described in other studies [7][8][9] while it is lower than others reported, ranging from 8 to 17% [10,11]; but the comparison has to be made with considerable caution, as there is a wide spectrum of autopsy rates in different countries.…”

Section: Discussionsupporting

confidence: 64%

Cardiomyopathies as a Cause of Sudden Cardiac Death (SCD) in Egypt: Recognition and Preventive Strategies Needed

Fnon¹,

Hassan²

2016

AJFSFM

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www.nauss.edu.sa http://ajfsfm.nauss.edu.sa Arab Journal of Forensic Sciences & Forensic Medicine investigated. Out of 535 cases of sudden cardiac death, there were 22 cases (4.1%) diagnosed as having cardiomyopathies; sudden death was their first presentation. Eighteen cases (81.8%) were male, with the 4th decade (11 cases, 50%) being the most affected age; severe physical activity and exertion were evident in death circumstances of 14 cases (63.6%); pathological evaluation revealed that hypertrophic cardiomyopathy was the most frequent type, being diagnosed in 10 cases (45%). Cardiomyopathies are an infrequent cause of sudden cardiac death. Most deaths are in children and adults, so cases are of high social impact that demands multidisciplinary research and resources. In all cases of SCD, forensic autopsy should be done. Forensic study is the key to identifying an affected family and the starting point regarding assessing them.

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Section: Discussionsupporting

confidence: 64%

Cardiomyopathies as a Cause of Sudden Cardiac Death (SCD) in Egypt: Recognition and Preventive Strategies Needed

Fnon¹,

Hassan²

2016

AJFSFM

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“…In the present study, examination of the myocardium revealed that there was acute myocardial infarction in 55.5% of cases. In previous studies, acute infarction was in the range of 33% to 48.5%, 15,18,45 whereas in another study, the acute infarction incidence was comparatively high (>60%) 15 . On the other hand, acute infarction has been found in other studies to be in less than 25% of cases 2,38 …”

Section: Discussionmentioning

confidence: 77%

Ischemic Heart Disease Related Sudden Cardiac Death in Autopsied Cases

Fnon

Hassan²,

Ibrahim³

2021

Am J Forensic Med Pathol

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Diagnosis of the underlying cause of sudden unexpected death in a previously healthy individual remains one of the important challenges in forensic practice. Ischemic heart disease is the most common cause of sudden death. The current study aims to investigate the incidence and pathology of sudden ischemic cardiac death in Egypt. All cases of sudden cardiac death (SCD) examined by different forensic departments throughout Egypt during the period of January 2010 through December 2014 were included. Cases underwent complete autopsy examination including a thorough gross and microscopic examination of the heart and great blood vessels. Of 535 cases of SCD diagnosed during the period of the study, coronary atherosclerosis was the principle finding in 420 (78.5%) cases. The highest numbers of deaths were reported in fifth and sixth decades with male preference. Other causes of SCD included myocarditis, cardiomyopathies, valvular heart disease, and hypertensive heart disease (7.8%, 4.1%, 4.1%, and 2.8%, respectively). There was severe stenosis (>75%) of at least 1 coronary artery in 74% of cases. Type VI atherosclerosis was found in 40.7% of cases. The left anterior descending branch was the most affected artery by atherosclerosis. Acute coronary pathological events were demonstrated in 27.6% of cases. Recent myocardial infarction was evident in 55.5% of cases, whereas old infarcts were demonstrated in 44.5% of cases. Features of hypertensive heart disease were present in 18.3% of cases. In conclusion, ischemic heart disease is the leading cause of SCD in Egypt.

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“…However, there is evidence that beta blockers reduce SCD in patients with previous MI (> 30% of our cohort) and statins are associated with reduction of ventricular tachycardia and SCD (40–42). These data underscore the need for improvement in the detection of old silent MIs and administering appropriate post-MI therapy (43). …”

Section: Discussionmentioning

confidence: 87%

Etiology of sudden death in the community: Results of anatomical, metabolic, and genetic evaluation

Adabag¹,

Peterson²,

Apple³

et al. 2010

American Heart Journal

120

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Is there unmet need for implantable cardioverter defibrillators? Findings from a post-mortem series of sudden cardiac death

Cited by 8 publications

References 13 publications

Cardiomyopathies as a Cause of Sudden Cardiac Death (SCD) in Egypt: Recognition and Preventive Strategies Needed

Cardiomyopathies as a Cause of Sudden Cardiac Death (SCD) in Egypt: Recognition and Preventive Strategies Needed

Ischemic Heart Disease Related Sudden Cardiac Death in Autopsied Cases

Etiology of sudden death in the community: Results of anatomical, metabolic, and genetic evaluation

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