Is there still a role for autologous stem cell transplantation in acute myeloid leukemia?

Abstract

Background: the role of autologous stem cell transplantation (ASCT) in treatment of acute myeloid leukemia (AML) remains unsettled. Aims: retrospective analysis to evaluate the role of ASCT in patients with AML without HLA-matched donor. Methods: between December 19, 1994 and August 1, 2012, a total of 63 patients with AML without HLA-matched donor in the department of Hematology and Transfusion Medicine, University Hospital, Bratislava, received an ASCT. Median age was 41 years (20-61 years). There were 35 (56%) males and 28 (44%) females. At the time of ASCT, 50 (79%) patients were in first complete remission (CR), 11 (18%) patients were in second CR and 2 (3%) patients were in relapse. Results: with a median follow-up of 115 months (34-214 months), the 10 year overall survival (OS) and disease free survival (DFS) of all patients was 55% and 51%, respectively. Transplant-related mortality was 6%. The relapse rate was 38% and 9 years probability of relapse was 44%. Conclusion: ASCT is still an effective post-remission treatment in AML patients without HLA-matched donor; with the possibility of long-term survival or even cure in remarkable proportion of patients with AML, particularly in patients with favorable and intermediate cytogenetic risk.

Akut myelositer lösemi hastalarında konsolidasyon tedavisi olarak otolog hematopoetik kök hücre nakli uygulaması

“…The median age was 43 years old in our study. In the literature the median age is between 37 and 53 years old which is compatible with our results (17)(18)(19)(20)(21)(22).…”

Obstetric Complications and Management in Chronic Myeloid Leukemia

“…Diagnosis during pregnancy is usually delayed as early symptoms of CML are nonspecific [3]. Choice of treatment is influenced by the time of diagnosis, clinical stage of the disease and the toxic effects of chemotherapeutic agents on mother and child [4].…”

“…The annual incidence is one per 75,000-100,000 pregnancies [1][2][3]. Leukaemias during pregnancy are primarily acute, two third being acute myeloid leukaemia (AML) and remaining one third acute lymphoblastic leukaemia (ALL).…”