Is There Still a Gender Gap in Cystic Fibrosis?

Verma, Nisha; Bush, Andrew; Buchdahl, Roger

doi:10.1016/s0012-3692(15)52709-8

Cited by 59 publications

(41 citation statements)

References 16 publications

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“…Although this finding will need to be verified in a larger cohort to ensure that it is not simply because of a type 1 error, this is the first study where airway function has been observed to be poorer in girls with cystic fibrosis during the first 2 years of life. A recent single centre study found no significant sex differences in either FEV 1 or growth centiles in school age children with cystic fibrosis, 45 but there have been many previous reports suggesting that affected male infants survive longer than female infants and that school age girls with cystic fibrosis exhibit significantly poorer lung function 15 and higher respiratory morbidity and mortality, 46 resulting in a 4 year difference in median survival 47 from their male counterparts.…”

Section: Clinical Significance Of Resultsmentioning

confidence: 94%

Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests

Lum¹,

Gustafsson

Ljungberg³

et al. 2007

Thorax

199

211

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Background: Lung clearance index (LCI), a measure of ventilation inhomogeneity derived from the multiplebreath inert gas washout (MBW) technique, has been shown to detect abnormal lung function more readily than spirometry in preschool children with cystic fibrosis, but whether this holds true during infancy is unknown. Objectives: To compare the extent to which parameters derived from the MBW and the raised lung volume rapid thoraco-abdominal compression (RVRTC) techniques identify diminished airway function in infants with cystic fibrosis when compared with healthy controls. Methods: Measurements were performed during quiet sleep, with the tidal breathing MBW technique being performed before the forced expiratory manoeuvres. Results: Measurements were obtained in 39 infants with cystic fibrosis (mean (SD) age 41.4 (22.0) weeks) and 21 controls (37.0 (15.1) weeks). Infants with cystic fibrosis had a significantly higher respiratory rate (38 (10) vs 32 (5) bpm) and LCI (8.4 (1.5) vs 7.2 (0.3)), and significantly lower values for all forced expiratory flow-volume parameters compared with controls. Girls with cystic fibrosis had significantly lower forced expiratory volume ) than boys (mean (95% CI girls-boys): -1.2 (-2.1 to 20.3) for FEV 0.5 Z score; FEF 25-75 : -1.2 (-2.2 to 20.15)). When using both the MBW and RVRTC techniques, abnormalities were detected in 72% of the infants with cystic fibrosis, with abnormalities detected in 41% using both techniques and a further 15% by each of the two tests performed. Conclusions: These findings support the view that inflammatory and/or structural changes in the airways of children with cystic fibrosis start early in life, and have important implications regarding early detection and interventions. Monitoring of early lung disease and functional status in infants and young children with cystic fibrosis may be enhanced by using both MBW and the RVRTC.

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Section: Clinical Significance Of Resultsmentioning

confidence: 94%

Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests

Lum¹,

Gustafsson

Ljungberg³

et al. 2007

Thorax

199

211

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“…Overall, there were no significant differences between respondents and nonrespondents in the parameters of interest. However, when examined by gender and age group (8)(9)(10)(11)(12) years, between 13 and 17 years and older than 17 years), for both males and females older than 17 years, the respondents had lower percent of predicted FEV 1 than the non-respondents (80.5% vs. 95.8% for males and 79.3% vs. 103.7% for females; P ¼ 0.01 for both comparisons). For AI, however, respondent girls had higher percent of predicted AI than non-respondent girls, but only in those younger than 12 years (104% vs. 95%, P ¼ 0.02).…”

Section: Resultsmentioning

confidence: 97%

“…[3][4][5][6][7][8][9] These gender differences in mortality remain poorly understood. Although nutritional status, airway microbiology, and pulmonary function are strong predictors of later mortality, reports of gender differences in these factors have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

“…Although nutritional status, airway microbiology, and pulmonary function are strong predictors of later mortality, reports of gender differences in these factors have been inconsistent. [6][7][8] From a stress theory perspective, 10 less attention has been given to how gender differences in sources of perceived stress (e.g., illness and relationship strains) and perceived resources for managing that stress (e.g., support from family and peers) may be associated with a behavioral outcome, in this case, treatment adherence behaviors. In an earlier study, we found that girls reported more illness-related strains than boys and these strains were associated with poorer adherence.…”

Section: Introductionmentioning

confidence: 99%

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Associations of psychosocial factors with health outcomes among youth with cystic fibrosis

Patterson

Wall

Berge

et al. 2008

Pediatric Pulmonology

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Summary. Purpose: The purpose of this study was to examine the relationship of strains, resources, feelings, and behaviors about treatment adherence reported by youth with cystic fibrosis (CF) with repeated clinic measures of their pulmonary function and nutritional status. Methods: Linear mixed models, stratified by gender, adjusting for age, were used to examine the effects of strains, resources, and adherence behaviors on repeated pulmonary function and nutritional status measures. All 10-21 years old with CF at the Minnesota Cystic Fibrosis Center were invited by mail to participate. Of these 177 youth, 51% (43 boys, 47 girls) returned surveys. Forced expiratory volume in 1 sec and predicted weight-for-height were extracted from participants' clinic records for the 18 months following receipt of the survey. Results: Females showed significantly greater variability in repeated measures of pulmonary function and nutritional status compared to males. Parent-youth strains, physical strains, activity limitations, and cough suppression had significant effects on the 18-month mean of pulmonary function measures for females, but only physical strains had a significant effect for males. Conclusion: Compared to males, females experienced more strains and poorer treatment adherence, which may be factors associated with declines in pulmonary function observed among females with CF during the adolescent years.

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“…Survival of patients with CF has dramatically improved since the disease was discovered, 70 years ago. Progressive pulmonary disease is leading to morbidity and pulmonary arrest, and the average life expectancy of people with 37.4 years, 37 years for women and 40 years for men (13,14). Progress in the length of life of patients is the result of many new improvement in treating disease.…”

Section: Discussionmentioning

confidence: 99%

The Analysis of Cystic Fibrosis in the Federation of Bosnia and Herzegovina

Selimović¹,

Mujičić²,

Milisic³

et al. 2016

RAD Conference Proceedings

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Aim:The aim of this study is to present the first total number of tested children in the Federation of Bosnia and Herzegovina and the number of children with positive sweat test. During the study we determined the number of ill children, the median age of children with cystic fibrosis, date of initial diagnosis, an average amount of chloride in the sweat. Material and methods: The study was a retrospective, conducted at the Department of Pulmonology Pediatric Clinic of University Clinical Center of Sarajevo. Results: In the period from March 2003 to December 2014, we have tested 625 children. 351 child were from Sarajevo Canton and 272 children from other cantons. Female children were more affected then male children, in the ratio of 1: 1,105. An average age of female children was 4.19±4.26 years, and the male 2.15±3.11 years. The median concentration of chloride in the sweat measured by sweat test was for male children 103.05±21.29 mmol/L, and for the female children 96.05±28.85 mmol/L. Conclusion: Most of children in Federation of Bosnia and Herzegovina have ∆F508 gene mutation. In the post-war period we started to use a sweat test. Male children tend to live longer than female children with CF.

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Is There Still a Gender Gap in Cystic Fibrosis?

Cited by 59 publications

References 16 publications

Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests

Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests

Associations of psychosocial factors with health outcomes among youth with cystic fibrosis

The Analysis of Cystic Fibrosis in the Federation of Bosnia and Herzegovina

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