Is there really an association between cytotoxic natural killer cells and implantation failure in both blood and endometrium?

Santillan, Isabel; Verdú, Victoria; Bajo, J.M.

doi:10.1016/j.jri.2011.06.029

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparative genome hybridization-based microarray analysis of 26 euploidic miscarriages picked up 11 unique inherited CNVs, two of them involve genes TIMP2 (86 kb duplication) and CTNNA3 (72 kb deletion) that are imprinted and maternally expressed in the placenta (Rajcan-Separovic et al, 2010). The first results of ongoing study using genome-wide genotyping data to map common CNVs demonstrated significantly more frequent prevalence of a 52.4-kb locus duplication on chromosome 5 among RM couples in Estonian and Danish population (Nagirnaja et al, 2011). These pilot studies alert for further investigations of rare and common CNVs as risk factors for RM.…”

Section: Advances and Future Directions In “Omics” And (Epi)geneticsmentioning

confidence: 99%

Genetics of Recurrent Miscarriage: Challenges, Current Knowledge, Future Directions

Rull¹,

Nagirnaja²,

Laan³

2012

Front. Gene.

135

111

View full text Add to dashboard Cite

Recurrent miscarriage (RM) occurs in 1–3% of couples aiming at childbirth. Due to multifactorial etiology the clinical diagnosis of RM varies. The design of genetic/“omics” studies to identify genes and biological mechanisms involved in pathogenesis of RM has challenges as there are several options in defining the study subjects (female patient and/or couple with miscarriages, fetus/placenta) and controls. An ideal study would attempt a trio-design focusing on both partners as well as pregnancies of the couple. Application of genetic association studies focusing on pre-selected candidate genes with potential pathological effect in RM show limitations. Polymorphisms in ∼100 genes have been investigated and association with RM is often inconclusive or negative. Also, implication of prognostic molecular diagnostic tests in clinical practice exhibits uncertainties. Future directions in investigating biomolecular risk factors for RM rely on integrating alternative approaches (SNPs, copy number variations, gene/protein expression, epigenetic regulation) in studies of single genes as well as whole-genome analysis. This would be enhanced by collaborative network between research centers and RM clinics.

show abstract

Section: Advances and Future Directions In “Omics” And (Epi)geneticsmentioning

confidence: 99%

Genetics of Recurrent Miscarriage: Challenges, Current Knowledge, Future Directions

Rull¹,

Nagirnaja²,

Laan³

2012

Front. Gene.

135

111

View full text Add to dashboard Cite

show abstract

Is there really an association between cytotoxic natural killer cells and implantation failure in both blood and endometrium?

Cited by 1 publication

References 0 publications

Genetics of Recurrent Miscarriage: Challenges, Current Knowledge, Future Directions

Genetics of Recurrent Miscarriage: Challenges, Current Knowledge, Future Directions

Contact Info

Product

Resources

About