Is there neural control over electrolyte reabsorption in the human salivary gland?

Levin, Sam; Khaikina, L. I.

doi:10.1042/cs0720541

Cited by 12 publications

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“…The salivary secretion is influenced by hormonal stimuli in rest and during exercise (17,33) . The action of parasympathetic hormones stimulates the saliva secretion resulting in a hypoconcentrated compound with low concentrations of organic substances (34) , while the sympathetic stimulation induces to saliva secretion with higher concentration of organic substances, making the medium to become hyperconcentrated (33,34) .…”

Section: Discussionmentioning

confidence: 99%

Comparação entre a utilização de saliva e sangue para determinação do lactato mínimo em cicloergômetro e ergômetro de braço em mesa-tenistas

Zagatto

Papoti

Caputo³

et al. 2004

Rev Bras Med Esporte

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O objetivo do estudo foi verificar a possibilidade de determinar o teste de lactato mínimo (TLM) com concentrações de sódio (Na+), potássio (K+) e lactato (LAC) na saliva em ergômetro de braço e cicloergômetro. Foram participantes deste estudo oito mesa-tenistas de nível internacional. Como estímulo anaeróbio no TLM em ambos os ergômetros foram utilizados testes máximos de 30 segundos. No ergômetro de braço isocinético (Cybex Ube 2432) foi aplicada a força máxima com rotação fixa em 102rpm e no cicloergômetro, aplicada a carga de 7,5% do peso corporal (Kp). Após o estímulo anaeróbio no ergômetro de braço, foi iniciado um teste incremental com rotações na manivela constante a 60rpm, iniciado a 49 watts com aumento de 16 watts a cada estágio de três minutos de exercício. A intensidade correspondente ao TLM foi determinado com amostras de sangue e saliva (LACmin braço; Na+min braço-saliva e K+min braço-saliva, respectivamente). Para o cicloergômetro, a carga inicial foi de 85 watts e aumento de 17 watts com rotação do pedal constante a 70rpm. Cada estágio de exercício também teve a duração de três minutos. O LACmin foi determinado utilizando amostras de sangue e saliva (LACmin ciclo; Na+min ciclo-saliva, K+min ciclo-saliva e LACmin ciclo-saliva, respectivamente). Em ambos os ergômetros, as intensidades obtidas no TLM foram correspondentes à derivada zero do ajuste polinomial entre metabólito versus intensidade. Foram utilizados, como procedimentos estatísticos, o teste ANOVA One Way, teste t de Student pareado e teste de correlação de Pearson com níveis de significância de 5%. Os LACmin determinados com amostras de sangue e de saliva, tanto para o ergômetro de braço (LACmin braço 91,71 ± 12,43; Na+min braço-saliva 71,99 ± 23,42; K+min braço-saliva 79,67 ± 17,72), quanto para cicloergômetro (LACmin ciclo 157,68 ± 13,48; LACmin ciclo-saliva 135,49 ± 33,2; Na+min ciclo-saliva 121,81 ± 51,31; K+min ciclo-saliva 135,49 ± 33,21), não foram diferentes significativamente. Contudo, essas intensidades não apresentaram correlações significativas. Pode-se então concluir que a utilização de metabólitos na saliva para determinação do TLM não parece ser possível para esse protocolo quando os ergômetros utilizados são o ergômetro de braço isocinético e o cicloergômetro.

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Section: Discussionmentioning

confidence: 99%

Comparação entre a utilização de saliva e sangue para determinação do lactato mínimo em cicloergômetro e ergômetro de braço em mesa-tenistas

Zagatto

Papoti

Caputo³

et al. 2004

Rev Bras Med Esporte

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“…Perhaps the strongest evidence for physiological regulation of salivary electrolyte composition comes from studies in humans with a parasympathetically denervated parotid gland caused by traumatic rupture of the tympanic nerve (Levin & Khaikina, 1987). In such patients, the concentrations of Na+ and Cl-in saliva secreted at a given rate following stimulation with pilocarpine or carbachol are markedly increased in the denervated gland compared with the innervated gland.…”

Section: Salivary Secretion4mentioning

confidence: 99%

Effects of acetylcholine, isoprenaline and forskolin on electrolyte and protein composition of rabbit mandibular saliva.

Case

Howorth

Padfield

1988

The Journal of Physiology

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SUMMARY1. The major purpose of this study was to investigate cellular regulation of the ductal transport processes in salivary glands which act to modify the electrolyte composition of primary saliva and cause it to become hypotonic. This was achieved using an isolated mandibular gland preparation by observing the effect of different stimuli on the electrolyte composition of saliva secreted at the same flow rate, on the assumption that these stimuli do not influence primary saliva composition. The effects of the same stimuli on the volume of primary fluid secretion and on protein secretion were also observed. Proteins were measured in total and as individual components after their separation by high-performance liquid chromatography.2. Acetylcholine was used as a 'Ca2+-mobilizing' agonist (i.e. one which both elevates intracellular Ca21 concentration and activates protein kinase C). Isoprenaline was initially used to elevate intracellular cyclic AMP concentration but was subsequently abandoned in favour of forskolin.3. Acetylcholine was a very potent stimulus of primary fluid secretion. By contrast, isoprenaline and forskolin were essentially without effect, even when superimposed on acetylcholine stimulation. 4. As judged by saliva electrolyte composition, increasing the concentration of acetylcholine enhanced ductal absorption of Na+ and Cl-and secretion of K+ (and presumably HCO3. Forskolin had the opposite effect: when superimposed on submaximal acetylcholine stimulation it caused saliva concentrations of Na+ and Cl-to remain high and K+ low (i.e. it inhibited ductal transport processes). The inhibitory effect of forskolin on ductal transport could be overcome by increasing the concentration of acetylcholine, and vice versa.5. Acetylcholine, isoprenaline and forskolin each increased salivary protein secretion, although the kinetics of secretion differed. The spectrum of proteins secreted in response to the three stimuli was the same. The relative proportions of the individual proteins was influenced by the strength of stimulation (i.e. the proportions at high total protein output differed from those at low total protein output) but not apparently by the nature of the stimulus.6. Thus, the three major secretory processes in the rabbit mandibular salivary gland respond differently to the two major signal transduction mechanisms. For R. M. CASE, A. J. HO WORTH AND P. J. PADFIELD primary fluid secretion, Ca2" is stimulatory and cyclic AMP almost without effect; for ductal transport, Ca2" is stimulatory and cyclic AMP inhibitory; and for protein secretion both Ca2+ and cyclic AMP are stimulatory.

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“…During the first stage, 10-14 days after trauma, and cessation of the reflex secretion, an increase in sensitivity to cholinomimetics (pilocarpine, carbacholine, acetylcholine) is observed. During the second stage (several months after trauma) and the third stage (still later) certain extremely intense and prolonged salivatory responses to cholinolytics take place (2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

PIRENZEPINE, TELENZEPINE, ATROPINE and METACINE AS AGONISTS FOR THE MUSCARINIC CHOLINORECEPTORS IN THE DENERVATED HUMAN PAROTID GLAND

Levin¹

2008

Journal of Clinical Pharmacy and Therapeutics

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Summary New anti‐ulcer preparations, pirenzepine and telenzepine, are structurally dissimilar to the classical cholinomimetics, atropine and hyoscine (scopolamine). However, they are all capable of provoking paradoxical salivation from the chronically parasympathetically denervated human parotid gland. The rates of the secretory responses to the typical and atypical cholino‐blockers are found to be the same. This finding is discussed with respect to the general functional mechanism of the traditional and non‐traditional antimuscarinic agents.

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Is there neural control over electrolyte reabsorption in the human salivary gland?

Cited by 12 publications

References 0 publications

Comparação entre a utilização de saliva e sangue para determinação do lactato mínimo em cicloergômetro e ergômetro de braço em mesa-tenistas

Comparação entre a utilização de saliva e sangue para determinação do lactato mínimo em cicloergômetro e ergômetro de braço em mesa-tenistas

Effects of acetylcholine, isoprenaline and forskolin on electrolyte and protein composition of rabbit mandibular saliva.

PIRENZEPINE, TELENZEPINE, ATROPINE and METACINE AS AGONISTS FOR THE MUSCARINIC CHOLINORECEPTORS IN THE DENERVATED HUMAN PAROTID GLAND

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