Is there evidence of a role of the phosphoinositol-cycle in the myocardium?

Courcelles, D. de Chaffoy de

doi:10.1007/978-1-4613-1611-4_10

Cited by 2 publications

(2 citation statements)

References 82 publications

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“…In agreement with one earlier study on rabbit retinal slices (Cutcliffe and Osborne, 1987) and consistent with studies on human platelets (de Chaffoy de Courcelles et al, 1985), rat aorta (Roth et al, 1984(Roth et al, , 1985, and rat cerebral cortex (Brown et al, 1984;Conn and Sanders-Bush, 1984, serotonin stimulated the accumulation of inositol phosphates by 5 1.6% in neuronal (3-day-old) retinal cultures (Fig. 3).…”

Section: Discussionsupporting

confidence: 92%

Agonist‐Induced Stimulation of Inositol Phosphates in Primary Rabbit Retinal Cultures

Ghazi

Osborne

1988

Journal of Neurochemistry

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Carbachol, noradrenaline, and serotonin stimulated the accumulation of inositol phosphates in a dose-dependent manner and maximally by 172.4%, 71.2%, and 51.6%, respectively, in 3-day-old rabbit retinal cultures. In contrast, dopamine, nicotine, isoproterenol, clonidine, 8-OH-dipropylaminotetralin, and gamma-aminobutyric acid were ineffective. In older cultures identified as containing primarily Müller cells, only carbachol and noradrenaline were able to induce a significant stimulatory response. The carbachol-, noradrenaline-, and serotonin-induced responses were pharmacologically characterized and shown to be mediated by muscarinic, alpha 1-adrenergic, and 5-hydroxytryptamine2 receptors, respectively. The results of the present study show that primary retinal cultures of 3 days of age give results comparable with those of the intact retina. Furthermore, it is demonstrated for the first time that putative Müller cells in cultures possess functional muscarinic and alpha 1-adrenergic receptors.

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Section: Discussionsupporting

confidence: 92%

Agonist‐Induced Stimulation of Inositol Phosphates in Primary Rabbit Retinal Cultures

Ghazi

Osborne

1988

Journal of Neurochemistry

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“…In fact, sphingosine also acts as an activator of DAG kinase, and it has been shown that DAG produced from PIP2 may not be a better substrate for DAG kinase activated by sphingosine (44). R59 949 is a very specific and potent DAG kinase inhibitor (45) and has been shown to inhibit DAG kinase in a concentration dependent manner (0.01 to 10 ~tM) in isolated platelet membranes (IC50=0,3 ~M) and in intact cells (ICs0=0.12 t~M). The fact that DAG kinase inhibitor R59 949 did not completely abolish the PA formation by sphingosine suggests that PLD is also activated by sphingosine apart from that mediated by PC-PLC and DAG kinase.…”

Section: As Shown Inmentioning

confidence: 99%

Sphingosine induces phospholipase D and mitogen activated protein kinase in vascular smooth muscle cells

1998

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: The enzymes phospholipase D and diacylglycerol kinase generate phosphatidic acid which is considered to be a mitogen. Here we report that sphingosine produced a significant amount of phosphatidic acid in vascular smooth muscle ceils from the rat aorta. The diacylglycerol kinase inhibitor R59 949 partially depressed sphingosine induced phosphatidic acid formation, suggesting that activation of phospholipase C and diacylglycerol kinase can not account for the bulk of phosphatidic acid produced and that additional pathways such as phospholipase D may contribute to this. Further, we have shown that phosphatidylethanol was produced by sphingosine when vascular smooth muscle cells were stimulated in the presence of ethanol. Finally, as previously shown for other cell types, sphingosine stimulated mitogen-activated protein kinase in vascular smooth muscle cells.

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Is there evidence of a role of the phosphoinositol-cycle in the myocardium?

Cited by 2 publications

References 82 publications

Agonist‐Induced Stimulation of Inositol Phosphates in Primary Rabbit Retinal Cultures

Agonist‐Induced Stimulation of Inositol Phosphates in Primary Rabbit Retinal Cultures

Sphingosine induces phospholipase D and mitogen activated protein kinase in vascular smooth muscle cells

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