Is There Evidence for Cognitive Intervention in Alzheimer Disease? A Systematic Review of Efficacy, Feasibility, and Cost-Effectiveness

Alves, Jorge; Magalhães, Rosana; Thomas, Roger E.; Gonçalves, Óscar F.; Petrosyan, Agavni; Sampaio, Adriana

doi:10.1097/wad.0b013e31827bda55

Cited by 48 publications

(39 citation statements)

References 25 publications

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“…This approach is considered appropriate for attenuating the intervention effects and for minimizing the cognitive engagement of subjects, as also indicated in another study. 29 Members of the CG were tested at baseline and during three follow-up phases by using the neuropsychological and clinical assessments at the same time as the EG. All study procedures for the CG were identical to the EG except that there was no intervention.…”

Section: Methodsmentioning

confidence: 99%

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The Effects of Cognitive Training for Elderly: Results from My Mind Project

Giuli

Papa

Lattanzio

et al. 2016

Rejuvenation Research

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Cognitive decline and dementia represent very important public health problems that impact the ability to maintain social function and independent living. The aim of this study was to investigate the effects of a nonpharmacological intervention consisting of comprehensive cognitive training in elderly people having one of three different cognitive statuses. In all, 321 elderly people with a diagnoses of mild–moderate Alzheimer's disease (AD), with mild cognitive impairment (MCI) and without cognitive decline were randomly assigned to two groups: experimental group (EG, who underwent intervention) and control group (CG), according to a prospective randomized intervention study. In the three groups, immediately after the end of the intervention, we observed a significant effect on some cognitive and noncognitive outcomes in the EGs. At the end of the intervention, we found an intermediate intervention effect on the Alzheimer's Disease Assessment Scale (ADAS) score of subjects with AD, as well as on functional status, as measured by using the Instrumental Activities of Daily Living scale. A significant intervention effect was also observed on enhancement of auditory verbal short-term memory and subjective memory complaints of subjects with MCI. The group of subjects without cognitive decline obtained a significant intervention effect on subjective complaints outcomes. The obtained results demonstrated that participation in the intervention could improve performance with respect to specific cognitive functions and psychological statuses. The role of healthy lifestyle programs, such as the use of comprehensive interventions, has been shown to be efficient for enhancing memory and other abilities in aged individuals with and without cognitive decline.

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Section: Methodsmentioning

confidence: 99%

“…The instruments were chosen in accordance with previous studies for assessment of distinctive domains. 12,29 …”

Section: Methodsmentioning

confidence: 99%

The Effects of Cognitive Training for Elderly: Results from My Mind Project

Giuli

Papa

Lattanzio

et al. 2016

Rejuvenation Research

View full text Add to dashboard Cite

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“…1 summarizes the review results. The search identified 14 relevant review articles [3,[12][13][14][15][16][17][18][19][20][21][22][23][24] and 5 Health Technology Assessment reports [25][26][27][28][29]. Two additional review articles [11,30] were added after review of citations.…”

Section: Methodsmentioning

confidence: 99%

Current issues and future research priorities for health economic modelling across the full continuum of Alzheimer's disease

Gustavsson

Green

Jones

et al. 2017

Alzheimer's & Dementia

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Available data and models for the health-economic evaluation of treatment in Alzheimer's disease (AD) have limitations causing uncertainty to decision makers. Forthcoming treatment strategies in preclinical or early AD warrant an update on the challenges associated with their economic evaluation. The perspectives of the co-authors were complemented with a targeted review of literature discussing methodological issues and data gaps in AD health-economic modelling. The methods and data available to translate treatment efficacy in early disease into long-term outcomes of relevance to policy makers and payers are limited. Current long-term large-scale data accurately representing the continuous, multifaceted, and heterogeneous disease process are missing. The potential effect of disease-modifying treatment on key long-term outcomes such as institutionalization and death is uncertain but may have great effect on cost-effectiveness. Future research should give priority to collaborative efforts to access better data on the natural progression of AD and its association with key long-term outcomes.

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“…High CR individuals seem to have a repertoire of strategies to resolve complex tasks, as well as redundant neuronal networks to carry out the same activities (22). Although several randomized controlled trials of cognitive intervention have yielded mixed and inconclusive results, the domain of global cognitive functioning, as measured by Mini-Mental State Examination, showed consistent and significant intervention effects (23). Recently the ACTIVE study group demonstrated the effects of cognitive training on cognitive abilities and everyday function over 10 yr.…”

Section: Risk Factors and Preventionmentioning

confidence: 99%

Primary Prevention of Alzheimer's Disease: Is It an Attainable Goal?

Han

2014

J Korean Med Sci

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Alzheimer's disease (AD) is the leading cause of dementia, and the most prevalent neurodegenerative disease in the elderly. The prevalence of AD is predicted to rise as life expectancy grows across populations. The exact cause of this devastating disease is still unknown; however, it is an aging-related multi-factorial disorder, and growing evidence supports the contribution of modifiable environmental factors to unmodifiable factors such as gene and ageing itself. The recent advancement of methodologies and techniques for early diagnosis of AD facilitates the investigation of strategies to reduce the risk for AD progression in the earliest stages of the disease. Pharmacological attempts at curing, halting or modifying it have, by and large, been unsuccessful, and no breakthrough is seen in the near future. However, a lot of elements that seem to contribute to the disease such as risk factors have been identified, mainly from epidemiological and basic research studies. Many of these are amenable to lifestyle modification. Therefore, prevention in the preclinical stage is likely the most effective way to decrease the incidence of this age-associated dreadful neurodegenerative condition, and its associated burden for individuals and society. We provide an overview of modifiable risk factors for AD along with the supporting evidence.

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Is There Evidence for Cognitive Intervention in Alzheimer Disease? A Systematic Review of Efficacy, Feasibility, and Cost-Effectiveness

Cited by 48 publications

References 25 publications

The Effects of Cognitive Training for Elderly: Results from My Mind Project

The Effects of Cognitive Training for Elderly: Results from My Mind Project

Current issues and future research priorities for health economic modelling across the full continuum of Alzheimer's disease

Primary Prevention of Alzheimer's Disease: Is It an Attainable Goal?

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