Is There Differences in Cognitive and Motor Functioning between Hemodialysis and Peritoneal Dialysis Patients?

Radić, Josipa; Ljutić, Dragan; Radić, Mislav; Kovačić, Vedran; Šain, Milenka; Dodig-Ćurković, Katarina

doi:10.3109/0886022x.2011.586480

Cited by 26 publications

(25 citation statements)

References 32 publications

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“…However, our study showed no differences in general CI and the major cognitive domains between case-matched PD and HD patients. This is different from the previous studies, which have indicated that the prevalence of general CI is lower in PD than in HD patients [9,10]. One study reported the comparable rates of CI between HD and PD but PD patients have more severe impairment in immediate memory and less impairment in executive dysfunction than HD patients [3].…”

Section: Discussioncontrasting

confidence: 56%

“…Also, magnetic resonance imaging (MRI) of the brain showed that structural neuroimaging abnormalities such as white matter hyperintensity (WMH), brain atrophy, and overt or silent cerebral infarction is prevalent among HD [5,6] or PD patients [7,8], as compared to healthy or CKD controls. However, a few studies have explored the influence of dialysis modality on the prevalence of CI [3,9,10] , or on the prevalence of structural and functional neuroimaging abnormalities [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Impairment and Structural Neuroimaging Abnormalities Among Patients with Chronic Kidney Disease

et al. 2016

Kidney Blood Press Res

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Background/Aims: Cognitive impairment and abnormal structural neuroimaging is common in chronic kidney disease patients. We aimed to explore its association with dialysis modality and the relationship between cognitive impairment and abnormal structural neuroimaging. Methods: Sixty peritoneal dialysis patients and 30 hemodialysis and 30 non-dialyzed stage 3-5 chronic kidney disease patients without history of stroke were enrolled for the study. Participants were matched for age, gender, education, diabetes status, and dialysis duration (if appropriate). Cognitive functions were measured using a battery of recognized instruments. Brain features were examined with 3-dimensional magnetic resonance imaging. Results: Cognitive impairment was significantly more severe in dialysis patients than in non-dialyzed patients. The global and specific cognitive function were not significantly different between patients on peritoneal dialysis and hemodialysis. Hemodialysis patients had more severe white matter hyperintensity, sulcal and ventricular atrophy, and SVIs than other patients. In all groups, higher white matter grade, ventricular grade, and hippocampal atrophy were significantly associated with global cognitive impairment, with hazard ratios of 1.80 (1.22-2.64), 1.67 (1.09-2.57), and 2.49 (1.07-5.77), respectively. White matter grade was also significantly associated with delayed memory (hazard ratio 1.63; 1.12-2.39). Conclusion: Dialysis modality showed no association with cognitive impairment, although hemodialysis patients had more severe neuroimaging abnormalities. For the whole group, white matter hyperintensity, and ventricular and hippocampal atrophy, were independently associated with global cognitive impairment in chronic kidney disease patients.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment and Structural Neuroimaging Abnormalities Among Patients with Chronic Kidney Disease

et al. 2016

Kidney Blood Press Res

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“…Both impaired cognitive function (33)(34)(35) and reduced physical performance measures (2,20,36) have been previously reported in patients established on PD. However, previous studies have not included data regarding functional independence.…”

Section: Discussionmentioning

confidence: 99%

Functional Disability in Older Adults Maintained on Peritoneal Dialysis Therapy

et al. 2016

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♦ Background: Older in-center hemodialysis patients have a high burden of functional disability. However, little is known about patients on home chronic peritoneal dialysis (PD). As patients opting for home dialysis are expected to play a greater role in their own dialysis care, we hypothesized that a relatively low number of PD patients would require help with basic self-care tasks (ADL) and instrumental activities of daily living (IADL). ♦ Methods: We used a cross-sectional study design to measure the proportion of patients aged 65 years and older undergoing outpatient PD who needed help with day-to-day activities. Patients living in nursing homes were excluded from the study. Functional dependence in ADL and IADL tasks were measured by the Barthel and Lawton Scales. Physical performance measures used included the timed up-and-go (TUG) test, chair stands and Folstein mini-mental score (MMSE).♦ Results: A total of 74 of 76 (97%) eligible PD patients participated. Patients had a mean age of 76.2 ± 7.5 years. Thirty-six percent had impaired MMSE scores, 69% were unable to stand from a chair without the use of their arms and 51% had abnormal TUG scores. Only 8 patients (11%) were fully independent for both ADL and IADL activities. Dependence in one or more ADL activity was reported by 64% of participants, while 89% reported dependence in one or more IADL. ♦ Conclusions: Impaired physical and functional performance is common in older patients maintained on PD. Collaborative geriatric-renal programs may be beneficial within the dialysis community.

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“…We selected these four tests from the CRD series because a strong correlation was found between the results on CRD-series tests and cognitive and psychomotor functions in previous studies with repeated-measures design [19,20,21,22]. The goal was to complete each test as quickly and with as few errors as possible.…”

Section: Methodsmentioning

confidence: 99%

“…The test procedure is noted online and guarantees unbiased documentation. In earlier studies, CRD-series was able to detect even the slightest cognitive and psychomotor changes [18,19,20,21,22,23]. …”

Section: Methodsmentioning

confidence: 99%

Kidney Transplantation Improves Cognitive and Psychomotor Functions in Adult Hemodialysis Patients

Radić

Ljutić²,

Radić³

et al. 2011

Am J Nephrol

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Background: Kidney failure is believed to have a negative impact on cognitive function, and cognitive impairment is common among maintenance hemodialysis (HD) patients. Previous studies have shown a beneficial effect of kidney transplantation in certain cognitive tests but not across all cognitive domains assessed. But, most of these studies performed a cross-sectional analysis, suffered from lack of standardization of adequate dialysis dose, hemoglobin level, and insufficient sensitivity of neuropsychological tests. The aim of this study was to evaluate the effect of successful kidney transplantation on cognitive and psychomotor function in adequately dialyzed HD patients without severe anemia, using sensitive neuropsychological tests. Methods: Twenty-one medically stable patients (aged 45.1 ± 7.9 years) on maintenance HD (7.6 ± 4.2 years) were investigated before and 20.5 ± 8.5 months after successful kidney transplantation using Complex Reactiometer Drenovac, a battery of computer-generated psychological tests which measure a simple visual discrimination of signal location, short-term memory, simple convergent visual orientation and convergent thinking. Results: Our findings indicated significantly better cognitive and psychomotor performance after transplantation on tests that assess processing speed, attention, short time memory, convergent thinking and executive functioning. Also, significant negative correlation between follow-up time after transplantation and cognitive and psychomotor performance in minimum time of solving test of convergent thinking was found. Conclusion: We conclude that cognitive and psychomotor functions are superior after successful kidney transplantation compared with HD, and that early beneficial effects of transplantation are not transient and cognitive and psychomotor performance might be even improved in time following successful transplantation.

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Is There Differences in Cognitive and Motor Functioning between Hemodialysis and Peritoneal Dialysis Patients?

Cited by 26 publications

References 32 publications

Cognitive Impairment and Structural Neuroimaging Abnormalities Among Patients with Chronic Kidney Disease

Cognitive Impairment and Structural Neuroimaging Abnormalities Among Patients with Chronic Kidney Disease

Functional Disability in Older Adults Maintained on Peritoneal Dialysis Therapy

Kidney Transplantation Improves Cognitive and Psychomotor Functions in Adult Hemodialysis Patients

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