Is there anything to the reported association between Helicobacter pylori infection and celiac disease?

Dettori, I.; Dore, Maria Pina; Marras, L.; Nieddu, Salvatore; Manca, Alessandra; Massarelli, G; Realdi, Giuseppe

doi:10.1016/s1590-8658(01)80181-x

Cited by 2 publications

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“…had the highest study population with 130308 participants (included 2689 cases and 127619 controls) [ 14 ]. Most studies were from Turkey (N = 6) [ 15 – 18 , 51 , 52 ] and Italy (N = 5) [ 11 , 27 , 44 , 45 , 48 ]. Some studies had been performed only on children [ 13 , 15 – 17 , 21 , 44 , 47 , 51 , 52 ] or adults [ 18 , 25 , 27 , 39 , 43 , 45 , 48 ], the others evaluated both age groups [ 11 , 14 , 42 , 49 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the full-texts of 92 remained articles were completely evaluated. Finally, 26 studies were included in the systematic review and also meta-analysis (kappa (κ) = 0.84) [11,[13][14][15][16][17][18]21,[24][25][26][27][39][40][41][42][43][44][45][46][47][48][49][50][51][52], and the others were excluded due to a reason mentioned in Fig 1 (Fig 1). In the end, there was no suitable cohort study in the included studies.…”

Section: Search Resultsmentioning

confidence: 99%

“…Most studies PLOS ONE were from Turkey (N = 6) [15][16][17][18]51,52] and Italy (N = 5) [11,27,44,45,48]. Some studies had been performed only on children [13,[15][16][17]21,44,47,51,52] or adults [18,25,27,39,43,45,48], the others evaluated both age groups [11,14,42,49,50]. Table 1 shows the details of the included articles.…”

Section: Characteristics Of the Included Articlesmentioning

confidence: 99%

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A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

et al. 2021

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Background and objectives Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization. Data sources Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated. Synthesis methods Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed. Results Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45–0.70; P < 0.001), with no publication bias (P = 0.825). The L’Abbé plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity. Conclusions According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients. Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=167730.

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Section: Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Characteristics Of the Included Articlesmentioning

confidence: 99%

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A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

et al. 2021

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“…were from Turkey (N = 6) [15][16][17][18]51,52] and Italy (N = 5) [11,27,44,45,48]. Some studies had been performed only on children [13,[15][16][17]21,44,47,51,52] or adults [18,25,27,39,43,45,48], the others evaluated both age groups [11,14,42,49,50]. Table 1 shows the details of the included articles.…”

Section: Plos Onementioning

confidence: 99%

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Is there anything to the reported association between Helicobacter pylori infection and celiac disease?

Cited by 2 publications

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A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

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