Is there any relationship between serum γ-glutamyltransferase levels and premature coronary artery disease?

Abstract

Original paper/Artykuł oryginalnyA b s t r a c t

Association Between Serum Gamma-Glutamyl Transferase and Alkaline Phosphatase with Presence of Premature Coronary Artery Disease: Findings from Khuzestan Comprehensive Health Study (KCHS)

“…No research study has investigated the association between the concentration of ALP and PCAD. In a study, as a supplementary analysis, no signi cant difference in concentration of ALP between the PCAD group and healthy controls was observed, which is in line with the result of our study [14].…”

“…Contrastingly, a study on 181 PCAD patients and 80 age and sexmatched controls demonstrated no signi cant difference between the concentrations of the GGT in the PCAD patients and controls. Moreover, the association between levels of the GGT and severity of the PCAD was investigated, and they came up with no signi cant differences between concentration of the GGT in patients with Gensini score ≤ 20 compared to those with Gensini score ≥ 20 [14]. The studies have small sample sizes and usually have been conducted in a tertiary center which may in uence the result of the study.…”

“…In the presence of iron ions, GGT stimulates low-density lipoprotein (LDL) oxidation and the production of reactive oxygen species and activated oxidative stress promotes in ammation [5,11,12]. The association between GGT levels and PCAD has been demonstrated in some reports [5,8,13], albeit it was not consistent across all studies [14]. Alkaline phosphatase (ALP) is a membrane metalloenzyme that hydrolyzes the pyrophosphate and has higher liver, kidney, and bone activity.…”