Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?

Çağlayan, Emel Kıyak; Üstün, Yaprak Engin; Göçmen, Ayşe Yeşim; Sarı, Nagihan; Seçkin, Levent; Kara, Mustafa; Polat, M. Fevzi

doi:10.1515/jpm-2015-0178

Cited by 42 publications

(35 citation statements)

References 20 publications

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“…A Danish study found a statistically significant association between HG and autoimmune diseases in general and in particular between HG and Sjögren's syndrome, Graves’ disease, rheumatoid arthritis, pernicious anaemia, coeliac disease, Crohn's disease, ulcerative colitis and psoriasis 23. Previous research has also found increased inflammatory markers in women with HG compared with healthy pregnancies 46, 47, 48, 49. Given that several of these conditions associated with HG also are associated with increased risk of CVD, we explored whether HG and CVD‐related mortality might be related.…”

Section: Discussionmentioning

confidence: 98%

“…23 Previous research has also found increased inflammatory markers in women with HG compared with healthy pregnancies. [46][47][48][49] Given that several of these conditions associated with HG also are associated with increased risk of CVD, we explored whether HG and CVD-related mortality might be related. Underlying mechanisms could be common genes or common environmental factors, and an inflammation during a restricted time-period could trigger Table 2.…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

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Hyperemesis gravidarum and long‐term mortality: a population‐based cohort study

Fossum

Vikanes

Næss

et al. 2016

BJOG

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ObjectiveTo investigate whether exposure to hyperemesis gravidarum (HG) is associated with increased maternal long‐term mortality.DesignPopulation‐based cohort study.SettingMedical Birth Registry of Norway (1967–2002) linked to the Cause of Death Registry.PopulationWomen in Norway with singleton births in the period 1967–2002, with and without HG. Women were followed until 2009 or death.MethodsCox proportional hazard regression model was applied to estimate hazard ratios (HRs) with 95% confidence interval (CI).Main outcome measuresThe primary outcome was all‐cause mortality during follow up. Secondary outcomes were cause‐specific mortality (cardiovascular mortality, deaths due to cancer, external causes or mental and behavioural disorders).ResultsOf 999 161 women with singleton births, 13 397 (1.3%) experienced HG. During a median follow up of 26 years (25 902 036 person‐years), 43 470 women died (4.4%). Women exposed to HG had a lower risk of long‐term all‐cause mortality compared with women without HG (crude HR 0.82; 95% CI 0.75–0.90). When adjusting for confounders, this reduction was no longer significant (adjusted HR 0.92; 95% CI 0.84–1.01). Women exposed to HG had a similar risk of cardiovascular death as women not exposed (adjusted HR 1.04; 95% CI 0.83–1.29), but a lower long‐term risk of death from cancer (adjusted HR 0.86; 95% CI 0.75–0.98).ConclusionIn this large population‐based cohort study, HG was not associated with an increased risk of long‐term all‐cause mortality. Women exposed to HG had no increase in mortality due to cardiovascular disease, but had a reduced risk of death from cancer.Tweetable abstractPopulation‐based cohort study: Hyperemesis was not associated with an increased risk of long‐term mortality.

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Section: Discussionmentioning

confidence: 98%

Section: Comparison With Other Studiesmentioning

confidence: 99%

Hyperemesis gravidarum and long‐term mortality: a population‐based cohort study

Fossum

Vikanes

Næss

et al. 2016

BJOG

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“…Recent studies have shown that NLR and PLR values are strongly associated with the diagnosis and prognosis of ulcerative colitis, tubo-ovarian abscesses, familial Mediterranean fever, brucella arthritis, and colorectal cancer [8,[14][15][16][17][18]. Although PLR changes in HEG patients have not been studied previously, two recent studies demonstrated that NLR levels are increased and correlated in patients with HEG [6,19]. However, these studies did not compare the accuracy of the results with other hematological and inflammatory markers besides hsCRP.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study

et al. 2017

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Objectives: Current evidence suggests that subclinical inflammation plays a significant role in the development of hyperemesis gravidarum (HEG). Simple hematological markers, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have been shown to reflect inflammatory burden and disease activity in several disorders. This study aimed to determine the diagnostic value of these hematological parameters for HEG. Material and methods:A total of 54 HEG patients and 58 age-and gestational-age-matched control subjects were studied. NLR, MPV, PLR, platelet distribution width (PDW), and red cell distribution width (RDW) values in all patients were calculated and recorded from complete blood cell counts.Results: For HEG patients, the median NLR was 3.2 (1.6-7.1), and the median PLR was 143.7 (78.1-334.6); for control subjects, the values were 2.1 (1.0-4.7) and 93.1 (47.3-194.7), respectively. Although both the NLR and PLR of HEG patients were found to be significantly higher than in the controls, no significant difference was found between the study groups in terms of MPV, RDW, or PDW. Correlation analysis revealed a significant correlation between NLR and CRP (r = 0.872, p < 0.001). Conclusions:Our results show that peripheral blood NLR and PLR values can reflect inflammatory burden in HEG patients and can be used as markers for HEG.

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“…The role of inflammatory markers in HG has been investigated in some recent studies, and a significant relationship between inflammatory markers such as neutrophil to lymphocyte ratio (NLR), vaspin, C‐reactive protein, tumor necrosis factor alpha, interleukin (IL)‐6 and sirtuin‐1 with HG has been reported …”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18] The role of inflammatory markers in HG has been investigated in some recent studies, and a significant relationship between inflammatory markers such as neutrophil to lymphocyte ratio (NLR), vaspin, C-reactive protein, tumor necrosis factor alpha, interleukin (IL)-6 and sirtuin-1 with HG has been reported. [19][20][21] However, because there is no data in the literature evaluating the relationship between the PLR, PCT and the presence and severity of HG, we investigated this association in the present study.…”

Section: Introductionmentioning

confidence: 99%

Association between platelet to lymphocyte ratio, plateletcrit and the presence and severity of hyperemesis gravidarum

Çift

Burcu

Özgen

et al. 2017

J of Obstet and Gynaecol

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Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?

Abstract: In HG, both SIRT1 level and NLR increased. In HG, this occurred as a response to metabolic alterations and potential inflammation.

Cited by 42 publications

References 20 publications

Hyperemesis gravidarum and long‐term mortality: a population‐based cohort study

Hyperemesis gravidarum and long‐term mortality: a population‐based cohort study

Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study

Association between platelet to lymphocyte ratio, plateletcrit and the presence and severity of hyperemesis gravidarum

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