Is There Any Relationship between Apolipoprotein E Polymorphism and Idiopathic Parkinson’s Disease?

Kwon, Oh Dae

doi:10.4172/2161-0460.1000296

Cited by 3 publications

(2 citation statements)

References 27 publications

(37 reference statements)

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“…PD and AD are both age-related diseases that have hallmarks of protein aggregation, indeed α-synuclein is found as a non-amyloid component within AD amyloid plaques and over 60% of AD cases are accompanied by the formation of Lewy bodies [10]. There are certain genetic variants that increase both PD and AD risk, for example the strong risk factor for AD, APOE4 , has been shown to be related to cognitive decline in PD [11]. There is evidence that molecular pathways, including mitochondrial function, oxidative stress and inflammation underlie the pathogenesis of both AD and PD, however, the pathogenic mechanisms of both diseases have not been entirely explained [8].…”

Section: Introductionmentioning

confidence: 99%

Gene expression meta-analysis of Parkinson’s disease and its relationship with Alzheimer’s disease

et al. 2019

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Parkinson’s disease (PD) and Alzheimer’s disease (AD) are the most common neurodegenerative diseases and have been suggested to share common pathological and physiological links. Understanding the cross-talk between them could reveal potentials for the development of new strategies for early diagnosis and therapeutic intervention thus improving the quality of life of those affected. Here we have conducted a novel meta-analysis to identify differentially expressed genes (DEGs) in PD microarray datasets comprising 69 PD and 57 control brain samples which is the biggest cohort for such studies to date. Using identified DEGs, we performed pathway, upstream and protein-protein interaction analysis. We identified 1046 DEGs, of which a majority (739/1046) were downregulated in PD. YWHAZ and other genes coding 14–3-3 proteins are identified as important DEGs in signaling pathways and in protein-protein interaction networks (PPIN). Perturbed pathways also include mitochondrial dysfunction and oxidative stress. There was a significant overlap in DEGs between PD and AD, and over 99% of these were differentially expressed in the same up or down direction across the diseases. REST was identified as an upstream regulator in both diseases. Our study demonstrates that PD and AD share significant common DEGs and pathways, and identifies novel genes, pathways and upstream regulators which may be important targets for therapy in both diseases. Electronic supplementary material The online version of this article (10.1186/s13041-019-0436-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Gene expression meta-analysis of Parkinson’s disease and its relationship with Alzheimer’s disease

et al. 2019

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“…In fact over 60% of AD cases are accompanied by the formation of Lewy bodies and αsynuclein is found as a non-amyloid component within AD amyloid plaques [12]. In addition, there are certain AGING genetic variants that increase the risk of both AD and PD, for example the strong risk factor for AD, APOE4, has been shown to be related to cognitive decline in PD [13].…”

Section: Introductionmentioning

confidence: 99%

Genetic networks in Parkinson’s and Alzheimer’s disease

Kelly

Moyeed

Carroll

et al. 2020

Aging

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Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common neurodegenerative diseases and there is increasing evidence that they share common physiological and pathological links. Here we have conducted the largest network analysis of PD and AD based on their gene expressions in blood to date. We identified modules that were not preserved between disease and healthy control (HC) networks, and important hub genes and transcription factors (TFs) in these modules. We highlighted that the PD module not preserved in HCs was associated with insulin resistance, and HDAC6 was identified as a hub gene in this module which may have the role of influencing tau phosphorylation and autophagic flux in neurodegenerative disease. The AD module associated with regulation of lipolysis in adipocytes and neuroactive ligand-receptor interaction was not preserved in healthy and mild cognitive impairment networks and the key hubs TRPC5 and BRAP identified as potential targets for therapeutic treatments of AD. Our study demonstrated that PD and AD share common disrupted genetics and identified novel pathways, hub genes and TFs that may be new areas for mechanistic study and important targets in both diseases.

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Understanding the (epi)genetic dysregulation in Parkinson's disease through an integrative brain competitive endogenous RNA network

Piergiorge,

Vasconcelos,

Santos-Rebouças

2024

Mechanisms of Ageing and Development

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Is There Any Relationship between Apolipoprotein E Polymorphism and Idiopathic Parkinson’s Disease?

Cited by 3 publications

References 27 publications

Gene expression meta-analysis of Parkinson’s disease and its relationship with Alzheimer’s disease

Gene expression meta-analysis of Parkinson’s disease and its relationship with Alzheimer’s disease

Genetic networks in Parkinson’s and Alzheimer’s disease

Understanding the (epi)genetic dysregulation in Parkinson's disease through an integrative brain competitive endogenous RNA network

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