Is there any relationship between RDW levels and atrial fibrillation in hypertensive patient?

Sarıkaya, Savaş; Sahin, Şevki; Akyol, Lütfi; Börekçi, Elif; Yılmaz, Yakup; Altunkaş, Fatih; Karaman, Kayıhan

doi:10.4314/ahs.v14i1.41

Cited by 19 publications

(13 citation statements)

References 31 publications

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“…Accordingly, the RDW is considered to be a good indicator of the prognosis of cardiovascular diseases, but few studies have been carried out in hypertensive patients. Sarikaya et al [ 14 ] found that the RDW levels were higher in hypertensive patients with AF. An increased RDW level in such patients with hypertension may alert physician on the development or presence of AF.…”

Section: Discussionmentioning

confidence: 99%

The neutrophil-to-lymphocyte ratio on admission is a good predictor for all-cause mortality in hypertensive patients over 80 years of age

Sun

Luo

Zhao

et al. 2017

BMC Cardiovasc Disord

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BackgroundImmuno-inflammation plays a major role in the process of hypertension. We aimed to evaluate the association between inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW) and all-cause mortality in elderly patients with hypertension.MethodsA total of 341 hypertensive patients over 80 years of age were included to this study. The NLR and RDW were measured on admission and all the selected patients were followed up for up to 90 days. Kaplan–Meier curves were plotted to evaluate the association between the NLR and the all-cause mortality at follow-up. Using Cox regression models, we investigated the prognostic value of NLR and RDW for all-cause mortality.ResultsPatients with higher quartile of NLR linked to high mortality in hypertensive patients at 90 day after admission (16.47%,13.25%,1.14%,1.17% respectively; χ2 = 20.581,P = 0.000). Surviving patients had lower RDW (13.61 ± 1.37 VS 14.18 ± 1.38, p = 0.041) and NLR (4.97 ± 5.72 VS 7.95 ± 6.88,p = 0.011). The receiver operating curve (ROC) of the NLR for all-cause mortality had an area under the curve (AUC) =0.714 (95%CI: 0.629–0.798, P = 0.000), with acritical value of 2.97, with sensitivity of 92.6%, and a specificity of 52.5%. The ROC of the RDW to predict all-cause mortality, had an AUC =0.654 (95%CI:0.548–0.761, P = 0.008), with acritical value of 13.2%.The Kaplan–Meier curve showed a significant difference between different NLR levels (p = 0.002). Multivariate Cox proportional hazard analysis shown 3rd quartile of NLR(RR = 9.646, 95% CI 1.302–34.457, P = 0.041) and 4th quartiles(RR = 16.451, 95% CI 2.137–66.643, P = 0.007) were found to independently predict all-cause death in hypertensive patients over 80 years of age. Higher rank of NLR was link to higher incidence of all-cause death for such patients.ConclusionThe findings of the present study demonstrate the potential utility of NLR in risk stratification of elderly patients with hypertension to provide information for clinical treatment strategies.

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Section: Discussionmentioning

confidence: 99%

The neutrophil-to-lymphocyte ratio on admission is a good predictor for all-cause mortality in hypertensive patients over 80 years of age

Sun

Luo

Zhao

et al. 2017

BMC Cardiovasc Disord

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“…Higher RDW levels were found in hypertensive patients with AF than in those without AF. Higher RDW levels in the hypertensive patients may remind the physicians of the development or presence of AF [ 56 ]. Potential association of RDW with AF history in patients with sick sinus syndrome (SSS) has been also evaluated by Korantzopoulos.…”

Section: Rdw and Cardiovascular Diseasesmentioning

confidence: 99%

Red Blood Cell Distribution Width: A Novel Predictive Indicator for Cardiovascular and Cerebrovascular Diseases

2017

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The red blood cell distribution width (RDW) obtained from a standard complete blood count (CBC) is a convenient and inexpensive biochemical parameter representing the variability in size of circulating erythrocytes. Over the past few decades, RDW with mean corpuscular volume (MCV) has been used to identify quite a few hematological system diseases including iron-deficiency anemia and bone marrow dysfunction. In recent years, many clinical studies have proved that the alterations of RDW levels may be associated with the incidence and prognosis in many cardiovascular and cerebrovascular diseases (CVDs). Therefore, early detection and intervention in time of these vascular diseases is critical for delaying their progression. RDW as a new predictive marker and an independent risk factor plays a significant role in assessing the severity and progression of CVDs. However, the mechanisms of the association between RDW and the prognosis of CVDs remain unclear. In this review, we will provide an overview of the representative literatures concerning hypothetical and potential epidemiological associations between RDW and CVDs and discuss the underlying mechanisms.

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“…Sarikaya et al[27] studied 126 patients with hypertension (63 with AF and 63 without) and reported that RDW values were significantly higher in patients with AF than in those without (15.1% ± 1.6% vs 14.0% ± 1.1%; P = 0.001). In multivariate logistic regression analysis, a RDW value > 14.2% was found to be independently associated with 1.8-fold higher risk (odds ratio, 1.85; 95%CI: 1.22-2.79) of AF.…”

Section: Description Of Studies Outcomementioning

confidence: 99%

Red blood cell distribution width: A marker of anisocytosis potentially associated with atrial fibrillation

Lippi

Cervellin

Sanchís-Gomar

2019

WJC

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The incorporation of biomarkers in the actually used risk scores seem to be helpful for early identifying atrial fibrillation (AF) patients at higher risk. The aim of this critical review of the scientific literature is to investigate the potential clinical significance of red blood cell distribution width (RDW) in AF. A systematic electronic search was carried out to identify all articles describing an epidemiological association between RDW and AF in adult human populations. Data abstraction was conducted on a final number of 35 articles (13 cross-sectional, 12 prospective and 10 retrospective studies). The results of these epidemiological investigations were all virtually concordant to emphasize that an enhanced RDW value is not only a predictive factor and a marker of AF but its measurement may also be helpful for predicting the risk of developing many adverse complications in patients with AF, such as recurrence and duration of AF, hospitalization for heart failure, bleeding, left atrial thrombosis and stasis, thromboembolic events and mortality. AF patients with RDW values exceeding the local reference range may be more aggressively investigated and managed, in order to identify and attenuate the impact of possible underlying disorders causing both anisocytosis and AF.

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Is there any relationship between RDW levels and atrial fibrillation in hypertensive patient?

Cited by 19 publications

References 31 publications

The neutrophil-to-lymphocyte ratio on admission is a good predictor for all-cause mortality in hypertensive patients over 80 years of age

The neutrophil-to-lymphocyte ratio on admission is a good predictor for all-cause mortality in hypertensive patients over 80 years of age

Red Blood Cell Distribution Width: A Novel Predictive Indicator for Cardiovascular and Cerebrovascular Diseases

Red blood cell distribution width: A marker of anisocytosis potentially associated with atrial fibrillation

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