“… 1 Owing to limited blood-brain barrier permeability, 2 , 3 NSCLC-BM present lower sensitivity to most cytotoxic and immune agents compared with extracranial sites. 4 , 5 Next-generation EGFR and ALK inhibitors and ROS1 , RET , MET , and NTRK inhibitors that penetrate the blood-brain barrier were found to have promising activity against BM in patients with NSCLC whose primary tumors carry mutations in these genes. 6 , 7 Nevertheless, it remains critical to identify specific pathogenic alterations in NSCLC-BM which can provide novel and more effective therapeutic targets.…”