Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?

Kaytez, Selda Kargin; Kavuzlu, Ali; Yumuşak, Nihat; Öcal, Ruhşen; Akkoca, Özlem

doi:10.1007/s00405-018-5181-3

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…Studies on this topic have focused on reducing or preventing MS by application of free radical scavengers, anti-inflammatory, and antioxidants agents. L-carnitine, selenium, Ginkgo biloba, ascorbic acid, N-acetylcysteine, zinc aspartate, vitamin C and E, N-nitro L- arginine methyl ester (L-NAME), Caffeic acid phenyl ester (CAPE), Hypericum perforatum, rosmarinic acid, montelukast, melatonin, dexamethasone and enoxaparin sodium have been used for this purpose in the current literature ( 1 , 2 , 6 , 9 , 15 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ). The effect of free radical scavengers is to arrest the formation of free radicals and active oxygen species, scavenging them, and repairing the damage.…”

Section: Discussionmentioning

confidence: 99%

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The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model

Eğilmez¹,

Güven²,

Elden³

et al. 2021

TAO

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Objective: The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS). Methods: Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol. Results: In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p<0.05). Fibrosis and inflammation regarding the lamina propria (LP) of the eardrums of the topical and oral eugenol groups were significantly less than those of the control and saline groups (p<0.001). In microscopic evaluation, TMs were found to be thicker in the control and saline groups (p<0.001). Conclusion: Our study showed that the application of topical and oral forms of eugenol reduced fibrosis and prevented the advancement of MS in the LP of the TMs in the short-term. More studies with different extracts are needed to investigate the efficacy of phytotherapeutic agents for preventing MS development following myringotomy.

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Section: Discussionmentioning

confidence: 99%

“…Myringosclerosis (MS) is the end-stage of the chronic inflammation, infection or injury in the tympanic membrane (TM) and usually seen following interventions such as ventilation tube insertion. It is represented by the hyaline degeneration of the elastic fibrils and calcification in the lamina propria (LP) of the TM ( 1 , 2 ).…”

Section: Introductionmentioning

confidence: 99%

The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model

Eğilmez¹,

Güven²,

Elden³

et al. 2021

TAO

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The Effect of Curcumin on the Prevention of Myringosclerosis in Rats

Akkoca¹,

Kaytez²,

Yumuşak³

et al. 2021

TAO

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Objective: The aim of this study was to investigate the preventative effect of oral curcumin (CMN) on myringosclerosis (MS) in an experimental rat model. Methods: The study included 21 female Wistar albino rats randomly separated into three groups. Group 1 was given no treatment (control group). In Group 2 and Group 3, the tympanic membrane (TM) was perforated using a sterile ear pick. The rats in Group 3 were administered oral CMN 200 mg/kg/day. All rats were sacrificed after 16 days. Otomicroscopic and histopathologic examinations were performed on the tympanic membranes. Results: Histopathologic examinations revealed that there were statistically significant differences between Group 2 and Group 3 in terms of MS degrees (p<0.001) and mean thicknesses of TMs (p<0.001), but there were no differences between Group 1 and Group 3. In respect of MS detected by otomicroscopy, a statistically significant difference was determined between Groups 1 and 2 (p<0.001) and between Groups 2 and 3 (p<0.01), but there was no significant difference between Group 1 and Group 3 (p=0.575). Conclusion: Orally administered CMN can prevent myringosclerosis formation in experimentally induced myringotomies.

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Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?

Cited by 2 publications

References 32 publications

The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model

The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model

The Effect of Curcumin on the Prevention of Myringosclerosis in Rats

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