Is there any difference regarding atopy between children with familial Mediterranean fever and healthy controls?

Aydoğmuş, Çiğdem; Ayaz, Nuray Aktay; Çakan, Mustafa; Çipe, Funda; Topal, Neval; Öner, Özlem; Keskindemirci, Gonca; Akçay, Arzu

doi:10.1016/j.aller.2016.12.006

Cited by 11 publications

(9 citation statements)

References 17 publications

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“…Th17 cells are also one of the important components of allergic inflammation and asthma. This cell subpopulation is accepted as the major evidence of interaction between innate and adaptive immunity (14). Also, new researches on innate immunity and new signaling pathways show that they play a role in both autoinflammatory diseases and allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…rhinitis, and atopy rates were lower in the children with FMF compared to the normal population, FMF was found to be protective in terms of atopic sensitization and allergic rhinitis (13). Aydogmuş et al demonstrated that children with FMF had a non-significantly increased prevalence of atopic dermatitis (5.08%), allergic rhinitis (28.8%), and asthma (15.25%) compared to the control group, but atopy rates and mean eosinophil counts were similar (14). In a recent children study, Yildiz et al demonstrated that the prevalence figures of asthma, atopic dermatitis, and allergic rhinitis were 4.2%, 0.72%, and 0.87%, respectively, and asthma was more frequent in those without the exon 10 mutation.…”

Section: Conflict Of Interestmentioning

confidence: 97%

See 1 more Smart Citation

Prevalence of Allergic Diseases in Patients with Common Autoinflammatory Diseases

Erdoğan¹,

Bilge²,

Kaşifoğlu³

2021

Asthma Allergy Immunol

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Objective: Autoinflammatory diseases are driven by abnormal activation of the innate immune system. Although allergic diseases are known to be mediated by the T helper 2 response, new mechanisms are put forward about the activation of innate immunity during exposure to allergens in recent years. Familial Mediterranean fever (FMF) and Behçet’s disease (BD) are the commonly seen autoinflammatory diseases in Turkey. It was aimed to determine the prevalence of allergic diseases in BD and FMF and contribute to explaining the relationship between autoinflammation and allergic diseases in this survey. Materials and Methods: The study included 42 patients with BD, 40 with FMF, 20 with other rheumatic diseases, and 20 healthy controls who had volunteered for allergic evaluation. Patients were questioned about allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, venom allergy, and food-drug allergy. The same prick test panel was used for all patients to investigate the presence of atopy. Results: Although the rate of allergic diseases and the blood eosinophil rate were significantly higher in patients with FMF and Behçet’s disease, which are commonly seen as autoinflammatory diseases, atopy rates were similar in all groups. The prevalence of allergic rhinitis and any allergic diseases was significantly higher in the FMF and BD groups (p: 0.03 and p: 0.02, respectively). In the multiple logistic regression model of the presence of any allergic disease, none of the factors was associated with allergic diseases. Conclusion: The prevalence of allergic diseases in patients with FMF and BD was found to be higher than in those with other rheumatic diseases and the control group but atopy rates were similar in all groups. The autoinflammatory diseases are not protective in terms of allergic sensitization and allergic rhinitis. This may be the result of recent advances in the innate immune sensing system. Keywords: Allergic diseases, autoinflammatory diseases, familial Mediterranean fever, Behçet’s disease, atopy

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Section: Discussionmentioning

confidence: 99%

Section: Conflict Of Interestmentioning

confidence: 97%

Prevalence of Allergic Diseases in Patients with Common Autoinflammatory Diseases

Erdoğan¹,

Bilge²,

Kaşifoğlu³

2021

Asthma Allergy Immunol

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show abstract

“…Genetic and environmental factors, as well as the design of study groups (children or adults), may have influenced the differences in the prevalence rate of atopy in autoimmune diseases. Another factor would be that some of those studies were based on the questionnaires (4)(5)(6)16). Epidemiologic studies were designed mostly on patients with SLE and RA (4,16).…”

Section: Discussionmentioning

confidence: 99%

“…Although, some studies reported the low prevalence of atopy in autoimmune diseases (4,5); the Th1/Th2 paradigm has been changed by the definition of Th17 and regulatory T (Treg) cells. Th17 play a role in the pathogenesis of both atopic and autoimmune diseases (6). Primary Sjögren's Syndrome (pSS) is a chronic autoimmune disease characterized by both organ-specific and systemic manifestations that primarily affects exocrine glands; especially the salivary and lacrimal, resulting in oral and ocular dryness due to lymphocyte infiltration and inflammation (7).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Atopic Status in Patients With Primary Sjogren’s Syndrome

Gültuna

Kepil

2020

Ankara Eğitim Ve Araştırma Hastanesi Tıp Dergisi

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The prevalence of atopy has been investigated in different autoimmune diseases in various studies. The atopic status in primary Sjögren's syndrome (pSS) patients has not been evaluated yet. We aimed to determine the relationship between pSS and atopy. MATERIAL AND METHOD:Fifty consecutive adult patients with pSS and fifty age and sex-matched controls were recruited in this study. pSS patients were evaluated with laboratory tests and disease activity score. All subjects underwent skin prick test with a standard panel of common aeroallergens. RESULTS:Ten patients (10/50, 20%) in the pSS group and six participants (6/50, 12%) in the control group had positivity on skin prick tests with common inhalant allergens (p=0.267). No significant differences were found regarding the clinical characteristics between atopic and non-atopic pSS patients. CONCLUSIONS:Atopic status and allergen sensitization were evaluated in pSS patients. To our knowledge, this is the first study investigating the inhalant allergen spectrum in pSS patients. The prevalence of atopy is similar in patients with pSS to the controls.

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“…Giảm nặng BCHTT bẩm sinh là một hội chứng suy giảm miễn dịch hiếm gặp có liên quan đến nhiều gen như: ELANE, HAX1, WAS, GFI1, G6PC3... [6], [8], [9]. Có hai phân nhóm chính của giảm nặng bạch cầu hạt trung tính bẩm sinh bao gồm: các đột biến gen trội nằm trên nhiễm sắc thể thường như đột biến gen ELANE (chiếm khoảng 40% -60% các trường hợp) và đột biến gen lặn trên nhiễm sắc thể thường như đột biến gen HAX1 (chiếm khoảng 30% các trường hợp).…”

Section: Bàn Luậnunclassified

Nhân một trường hợp giảm nặng bạch cầu hạt trung tính do đột biến mới ở gen HAX1

Tham¹,

Quang²,

Wada³

et al. 2018

JPRP

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Đặt vấn đề: Giảm nặng bạch cầu hạt trung tính bẩm sinh là một bệnh hiếm liên quan đếnđột biến gen. Một số gen đột biến gây giảm nặng bạch cầu hạt trung tính như gen ELANE,HAX1, WAS.....Đột biến trên gen HAX1 là đột biến gen lặn trên nhiễm sắc thể thường gâynên giảm nặng bạch cầu hạt trung tính. Bệnh nhân mang gen đột biến thường bị nhiễm trùngnặng, tái diễn và có nguy cơ tiến triển thành bạch cầu cấp.Mục tiêu: Mô tả một trường hợp giảm nặng bạch cầu hạt trung tính do đột biến gen mớiở gen HAX1.Đối tượng và phương pháp: Mô tả ca bệnh: Một trẻ nam 7 tuổi chậm phát triển tinhthần vận động vào viện vì nhiễm trùng nặng kèm theo giảm bạch cầu hạt trung tính.Kết quả: Phát hiện đột biến dịch khung, đồng hợp tử trên gen HAX1 (c.423_424insG,p.Gly143fs) gây giảm bạch cầu hạt trung tính bẩm sinh. Đây là đột biến mới, chưa từng xuấthiện trong y văn.Kết luận: Kết quả nghiên cứu của chúng tôi cung cấp thêm bằn chứng về vai trò của genHAX1 trong giảm nặng bạch cầu hạt trung tính.

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Is there any difference regarding atopy between children with familial Mediterranean fever and healthy controls?

Abstract: Children with FMF did not show an increase of atopic dermatitis, allergic rhinitis and asthma with respect to controls.

Cited by 11 publications

References 17 publications

Prevalence of Allergic Diseases in Patients with Common Autoinflammatory Diseases

Prevalence of Allergic Diseases in Patients with Common Autoinflammatory Diseases

Evaluation of Atopic Status in Patients With Primary Sjogren’s Syndrome

Nhân một trường hợp giảm nặng bạch cầu hạt trung tính do đột biến mới ở gen HAX1

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