Is There Any Difference in Recurrence Rates in Laparoscopic Ileocolic Resection for Crohn's Disease Compared With Conventional Surgery? A Long-Term, Follow-Up Study

Lowney, Jennifer K.; Dietz, David W.; Birnbaum, Elisa H.; Kodner, Ira J.; MUTCH, M; Fleshman, James W.

doi:10.1007/s10350-005-0214-6

Cited by 108 publications

(60 citation statements)

References 12 publications

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“…No differences were found in the recurrence rate or the disease-free interval when laparoscopic technique was compared with open surgery in a retrospective analysis of 61 consecutive patients performed in a tertiary Canadian centre [33] . Similar results were obtained in a retrospective study involving a larger cohort of 113 patients [34] . Recently, long-term results of laparoscopic-assisted or open ileocolic resection for Crohn's disease have been compared in terms of surgical recurrence, quality of life, body image, and cosmetics [35] .…”

Section: Surgery-related Factorssupporting

confidence: 88%

Postoperative Crohn’s disease recurrence: A practical approach

Nos¹,

Domènech²

2008

WJG

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risk patients. Nitroimidazolic antibiotics, although efficient, are associated with a high rate of intolerance and might induce irreversible side effects when used for a long-term. Thiopurines are not widely used after ileocecal resection, maybe because some concerns in giving immunomodulators in asymptomatic patients still remain. In the era of biological agents and genetic testing, a well-established preventive strategy for POR is still lacking, and larger studies to identify good clinical, serological, and genetic predictors of early POR as well as more effective drugs (or drug combinations) are needed.

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Section: Surgery-related Factorssupporting

confidence: 88%

Postoperative Crohn’s disease recurrence: A practical approach

Nos¹,

Domènech²

2008

WJG

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“…As a potential bias, the median follow-up periods were significantly different (62.9 months for the laparoscopic and 81.8 months for the open surgery group). 37 The difference in the follow-up periods between the two groups in this study was of statistical significance. The median follow-up duration for open surgery group was 9 years, whereas it was only 6 years for the laparoscopic group.…”

Section: Postoperative Outcomementioning

confidence: 57%

Long-term outcome of laparoscopic and open surgery in patients with Crohn’s disease

Hoffmann¹,

Siebrasse²,

Schlöricke³

et al. 2017

OAS

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Aim:To investigate, via data analysis, the long-term outcome of patients who underwent either laparoscopic or open surgery for Crohn's disease. Methods: A total of 113 patients who had undergone first abdominal surgery due to Crohn's disease between January 2000 and December 2010 in a maximum care provider facility, were included in the statistical analysis. All patients provided their informed consent prior to inclusion. Data were collected from a database. Follow-up data included data from central mortality registries, general practitioners and a specialized clinic. Statistical analysis of the general patient data and the different operations and approaches were performed with the use of chi-square test, Fisher's exact test, and the Mann-Whitney U test. Results: The median follow-up period in case of open and laparoscopic surgery was found to be 9 and 6 years, respectively. Statistically significant differences were observed for the following parameters in case of open and laparoscopic surgery, respectively: age (median=44 vs. 36 years, range=15-76 vs. 15-72 years; p=0.007), urgency of operation (23 out of 34 planned vs. 6 out of 70 planned; p<0.001), year of resection (median=2003 vs. 2006, range=2000-2010 vs. 2000-2010; p=0.001). The length of stay in hospital was significantly shorter in the laparoscopic group than that of open surgery group (8 vs. 11 days, respectively; p<0.0001). We did not control for factors such as age and comorbidities in our statistical analysis. We also did not find any differences with regard to perioperative and 90-day mortality, surgical complications, length of specimen, stoma, surgical recurrence rate (10% in both groups) and number of re-admissions. Moreover, we did not find differences between patients with early operation after first symptoms and patients with long course of disease. A statistically significant difference was found for long-term mortality that was higher in the open surgery group than that of laparoscopic group (p=0.005) (the median for open surgery group was significantly higher than that of laparoscopic group). Conclusion: The outcome of laparoscopic and open surgery is at least comparable. Shorter length of hospital stay and comparable surgical recurrence rates are advantages of laparoscopy.

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“…Vale citar que apesar do grande número de publicações disponíveis, demonstrando, por exemplo, que as ressecções íleocólicas vídeo-assistidas são factíveis e seguras a factibilidade no tratamento da doença de Crohn, a maioria destas experiências não têm grupo controle ou consiste de ensaios não randomizados 19,20,21,22,23,24,25,26,27,28,29 .…”

Section: Resultados Da Videocirurgia Na Doença De Crohnunclassified

Videocirurgia no manejo da doença de Crohn intestinal

Araújo

Dias

Seid

et al. 2010

Rev bras. colo-proctol.

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RESUMO: A doença de Crohn é uma moléstia com um amplo espectro de manifestações. Seu tratamento é complexo e freqüentemente os pacientes portadores desta afecção necessitam de intervenções cirúrgicas. Com o surgimento da laparoscopia e sua popularização no tratamento das afecções intestinais, demonstrando resultados superiores ao acesso convencional e quebrando paradigmas como sua utilização no tratamento do câncer colorretal, passou-se a cogitar se esse acesso seria indicado também nas doenças inflamatórias intestinais. Ainda hoje, a utilização desta via de acesso na doença de Crohn é tema controverso. Devido à natureza inflamatória desta patologia, o grau de dificuldade cirúrgico está aumentado e muitas dúvidas persistem: há benefício para o paciente? A taxa de conversão não está exageradamente aumentada? É possível indicar esse acesso em casos complicados? Qual o grupo de pacientes que se beneficia da técnica? Nesta revisão apresentamos os dados mais recentes e as evidências científicas que sustentam a indicação da via de acesso laparoscópica no tratamento cirúrgico da doença de Crohn. Descritores

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Is There Any Difference in Recurrence Rates in Laparoscopic Ileocolic Resection for Crohn's Disease Compared With Conventional Surgery? A Long-Term, Follow-Up Study

Abstract: In this study, the long-term outcome after laparoscopic ileocolic resection was not shown to be statistically different from that of open ileocolic resection. The relatively low recurrence rates in both groups may be explained by our aggressive use of chemoprophylaxis.

Cited by 108 publications

References 12 publications

Postoperative Crohn’s disease recurrence: A practical approach

Postoperative Crohn’s disease recurrence: A practical approach

Long-term outcome of laparoscopic and open surgery in patients with Crohn’s disease

Videocirurgia no manejo da doença de Crohn intestinal

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Is There Any Difference in Recurrence Rates in Laparoscopic Ileocolic Resection for Crohn's Disease Compared With Conventional Surgery? A Long-Term, Follow-Up Study

Abstract: In this study, the long-term outcome after laparoscopic ileocolic resection was not shown to be statistically different from that of open ileocolic resection. The relatively low recurrence rates in both groups may be explained by our aggressive use of chemoprophylaxis.

Cited by 108 publications

References 12 publications

Postoperative Crohn’s disease recurrence: A practical approach

Postoperative Crohn’s disease recurrence: A practical approach

Long-term outcome of laparoscopic and open surgery in patients with Crohn&rsquo;s disease

Videocirurgia no manejo da doença de Crohn intestinal

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Product

Resources

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Long-term outcome of laparoscopic and open surgery in patients with Crohn’s disease