Is There Any Correlation Between De Ritis Ratio and Prostate Cancer in Males Who Underwent Transrectal Prostate Biopsy?

Şahin, Yusuf; Yılmaz, Mehmet; Hacıbey, İbrahim; Filtekin, Yiğit Can; Colakerol, Aykut; Semerciöz, Atilla; Müslümanoğlu, Ahmet Yaser

doi:10.4274/bmb.galenos.2020.11.078

Cited by 2 publications

(4 citation statements)

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“…AST and ALT enzymes are related to glutamine metabolism, essential for cancer cells to produce nucleotides and nonessential amino acids [58][59][60]. Therefore, AST and ALT, representing tumour metabolism, act as biomarkers to predict disease prognosis [42,54,61].…”

Section: Resultsmentioning

confidence: 99%

Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer

Hamodat,

Abdulwahhab,

Hamodat

2024

Ukr.Biochem.J.

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Search for reliable biomarkers for predicting progression of breast cancer is essential in managing the disease. So, we are trying to provide new insights into the potential role of alpha-fucosidase (AFU) as a putative prognostic biomarker in breast cancer as compared to classic markers. The study included 56 women with breast cancer; 25 had early breast cancer, and the rest (31) had metastatic breast cancer. Thirty healthy women were considered a control group. Early breast cancer patients had a significantly increased (P ≤ 0.0001) AFU level compared with the control group. A non-significant difference in the De-ritis ratio appeared for early breast cancer compared with control. Metastatic breast cancer had a significantly (P ≤ 0.0001) increased AFU and De-ritis ratio compared with early breast cancer and the control group. A positive significant (P = 0.01) correlation exists between AFU level, age factor (r = 0.295), and the De-ritis ratio in breast cancer patients. We can conclude that it is possible to consider alpha-L-fucosidase (AFU) as a putative prognostic biomarker in breast cancer more potent than the ratio of De-Ritis. Moreover, the coincidence of elevated AFU and De-ritis levels in metastatic breast cancer gives us an idea of the stage of the disease. Keywords: alpha-L-fucosidase, early breast cancer, metastasis, the De-ritis ratio

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Section: Resultsmentioning

confidence: 99%

Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer

Hamodat,

Abdulwahhab,

Hamodat

2024

Ukr.Biochem.J.

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“…AST is one of the important components of the malate-aspartate shuttle pathway that allows NADH/ NAD conversion. 9,13 In addition, AST is generally produced in different tissue types such as kidney, heart, gastric mucosa, adipose tissue, skeletal muscle, and brain, while ALT is considered more liver-specific. Accordingly, a more serious increase in AST level is observed in tissue damage secondary to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, a more serious increase in AST level is observed in tissue damage secondary to oxidative stress. 8,9,12 The relationship between kidney cancer and De Ritis rate has been studied in detail in recent years. The case series of 698 cases by Bezan et al 11 reported that the AST/ALT ratio was evaluated preoperatively as an independent prognostic factor in patients with non-metastatic RCC.…”

Section: Discussionmentioning

confidence: 99%

“…8 The De Ritis ratio, calculated by dividing AST by ALT, was first described by Fernando De Ritis in 1957 as a diagnostic marker for viral hepatitis. 8,9 It is also used as an independent predictor of patient survival in chronic liver diseases. 10 On the other hand, intensive research has been carried out recently to show that the ratio of De Ritis will change in various malignancies according to the differences in the functions of these two enzymes in tissue distribution and energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of pretreatment De Ritis ratio in renal cell carcinoma

Kölükçü,

Fırat,

Yalçın

et al. 2024

Journal of Health Sciences and Medicine

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Aims: This study aimed to investigate the relationship between pretreatment De Ritis ratio and Fuhrman nuclear grade and tumor stage in renal cell carcinoma (RCC). Methods: The data of 288 patients treated for RCC were analyzed. The De Ritis ratio was evaluated in patients classified by Fuhrman nuclear grade and tumor stage. The De Ritis ratio between groups was compared using Levene’s test. Results: A total of 145 patients (50.3%) were women female. Their mean age, aspartate aminotransferase, alanine aminotransferase values, and De Ritis ratio were as follows, respectively: 60.32±12.65 years, 20.55±11.54 IU/L, 17.4±10.87 IU/L, and 1.34±0.75. The De Ritis ratio was 1.12±0.44 in the low stage group and 2.01±1.05 in the high stage group. According to the Fuhrman nuclear grading, the De Ritis ratio was 1.15±0.43 in the low grade group and 1.70±1.14 in the high grade group. There was a statisticallysignificant difference between the groups (p

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Is There Any Correlation Between De Ritis Ratio and Prostate Cancer in Males Who Underwent Transrectal Prostate Biopsy?

Cited by 2 publications

References 0 publications

Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer

Alpha-L-fucosidase as a putative prognostic biomarker in breast cancer

Clinical significance of pretreatment De Ritis ratio in renal cell carcinoma

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