Is there any benefit from evaluation of exercise NT-proBNP concentrations in asymptomatic patients with severe high-gradient aortic stenosis?

Dobrowolski, Piotr; Lech, Agnieszka; Klisiewicz, Anna; Hoffmań, Piotr

doi:10.20452/pamw.3494

Cited by 5 publications

(7 citation statements)

References 9 publications

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“…Although additional technics like the echocardiographic assessment of LV function, cardiopulmonary test, risk score (CURRENT-AS), and biomarkers might improve diagnostic, their role in AAS management requires further investigation to justify a class I indication for surgery instead of classic ET [31][32][33][34][35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Exercise test in patients with asymptomatic aortic stenosis – clinically useful or not?

Orłowska−Baranowska¹,

Baranowski²,

Hryniewiecki³

2021

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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Section: Discussionmentioning

confidence: 99%

Exercise test in patients with asymptomatic aortic stenosis – clinically useful or not?

Orłowska−Baranowska¹,

Baranowski²,

Hryniewiecki³

2021

Polish Archives of Internal Medicine

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“…In a study by Goodman et al, 11 BNP added an incremental prognostic utility to known predictors of mortality, such as the Society of Thoracic Cardiovascular Surgeons score. 11 Interestingly, in the study by Dobrowolski et al, 8 resting levels of NT-proBNP did not correlate with LV ejection fraction (LVEF) or indexed stroke volume, again confirming the already known fact that LVEF is a suboptimal parameter of true LV systolic function and usually is not affected until late in the course of the disease. In a study by Kafa et al, 12 patients with severe AS Aortic stenosis (AS) is the most common valvular disease in Western countries.…”

mentioning

confidence: 84%

The conundrum of watchful waiting versus pre-emptive surgery in asymptomatic aortic stenosis: are we any closer to an answer?

Desai

Mentias

2016

Polish Archives of Internal Medicine

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“…Three studies examined the role of exercise BNP in patients with asymptomatic severe AS. [9][10][11]13 The largest of these by Capoulade et al showed that BNP level increased significantly from rest to peak exercise (P < .0001) and both, while resting and peak exercise BNP levels were strongly correlated (r = 0.89, P < .0001), peak exercise BNP was associated with mean gradient, left atrial area and valvulo-arterial impedance (Zva). Furthermore, during a mean follow-up of 1.8 ± 1.3 years, BNP levels during exercise were significantly associated with an increased risk of death or aortic valve replacement after adjusting for clinical, echocardiographic and exercise variables.…”

Section: Aortic Stenosis (As)mentioning

confidence: 98%

“…NT pro-BNP did, however, track to left ventricular mass index, mean gradient and aortic valve area. 11…”

Section: Aortic Stenosis (As)mentioning

confidence: 99%

Natriuretic peptide release during exercise in patients with valvular heart disease: A systematic review

et al. 2021

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Aim: Serum biomarkers have a potential role in the risk stratification of patients with heart valve disease and may help determine the optimal timing of intervention. Much of the published literature relates to biomarker sampling in a resting state, but the relationship of exercise biomarkers is less well described. We performed a systematic review to examine the significance of exercise natriuretic peptides on echocardiographic variables and cardiovascular events, in valvular heart disease. Methods:A search for studies that assessed exercise biomarkers in patients with moderate to severe valve lesions was performed. We examined the relationship between rest and exercise BNP and also the endpoints of symptoms, haemodynamic or echocardiographic variables and clinical outcomes.Results: Eleven prospective studies were identified (844 participants). 61% were male and the mean age was 55.2 ± 9.6 years. The majority of the blood samples were taken at baseline and within 3 minutes of stopping exercise. There was a significant increase in exercise BNP compared with rest, in patients with aortic stenosis, mitral regurgitation and mitral stenosis. Elevated exercise BNP levels correlated with mean gradient and left atrial area, and there was a relationship between a higher exercise BNP and a blunted blood pressure response, in aortic stenosis. Furthermore, exercise BNP was independently associated with cardiac events, over and above resting values, in patients with mitral regurgitation and aortic stenosis. How to cite this article: Badiani S, van Zalen J, Althunayyan A, et al. Natriuretic peptide release during exercise in patients with valvular heart disease: A systematic review. Int J Clin Pract.

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Is there any benefit from evaluation of exercise NT-proBNP concentrations in asymptomatic patients with severe high-gradient aortic stenosis?

Cited by 5 publications

References 9 publications

Exercise test in patients with asymptomatic aortic stenosis – clinically useful or not?

Exercise test in patients with asymptomatic aortic stenosis – clinically useful or not?

The conundrum of watchful waiting versus pre-emptive surgery in asymptomatic aortic stenosis: are we any closer to an answer?

Natriuretic peptide release during exercise in patients with valvular heart disease: A systematic review

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