Is there any association of apolipoprotein E gene polymorphisms with metabolic syndrome in a young population of Croatian origin?

Karmelić, Ivana; Lovrić, Jasna; Božina, Tamara; Merkler, Ana; Božina, Nada; Sertić, Jadranka

doi:10.1080/03014460.2016.1210675

Cited by 2 publications

(1 citation statement)

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“…Some studies have been conducted exclusively in the male population with conflicting findings. For example, a small study among young Croatian males revealed no association between any APOE genotype and the prevalence MetS [ 29 ], which was in line with our findings, whereas another study among middle-aged American males found an increased risk of MetS among those with APOE E4 [ 22 ]. We found no studies in a female only cohort.…”

Section: Discussionsupporting

confidence: 90%

Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians

Azhuvalappil,

Prasad,

Sahadevan

et al. 2024

Metabolism Open

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Section: Discussionsupporting

confidence: 90%

Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians

Azhuvalappil,

Prasad,

Sahadevan

et al. 2024

Metabolism Open

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Metabolic syndrome and its association with the Dietary Inflammatory Index (DII)^® in a Croatian working population

Jovanović

Žeželj

Majanović

et al. 2019

J Human Nutrition Diet

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BackgroundMetabolic syndrome (MetS) is a global public health concern, although its association with the inflammatory potential of the diet is still indefinite. The main objective of the present study was to investigate the association of MetS and its components with the inflammatory potential of the diet in a Croatian working population with sedentary occupations.MethodsIn a cross‐sectional study, Croatian workers (n = 366) self‐administrated questionnaires for sociodemographic and health‐related data. Their anthropometric measurements and fasting blood samples were collected for evaluation of MetS. The inflammatory potential of the diet was assessed with a Dietary Inflammatory Index (DII)®, scored using dietary data collected from a food frequency questionnaire. Multivariable logistic regression analysis, adjusted for sex, age, body mass index, education, smoking, physical activity and energy intake, was used to establish the association between DII and MetS.ResultsMetS prevalence was 25% and was significantly associated with a pro‐inflammatory diet [mean (SD) 3.28 (1.45); P < 0.01]. The pro‐inflammatory diet was statistically associated with women, university degree, moderate physical activity, snacking between meals, central obesity, hypertriglyceridaemia, hypertension, low high‐density lipoprotein‐cholesterol, MetS prevalence and lower adherence to a Mediterranean diet. Multivariable logistic regression analysis showed a statistically positive association for a one‐unit increase in the DII and MetS prevalence (odds ratio = 2.31; 95% confidence interval = 1.61–3.31; P < 0.01) and hypertension (odds ratio = 1.28; 95% confidence interval = 1.01–1.64; P = 0.04).ConclusionsFurther longitudinal studies in different parts of Croatia, including inflammation biomarkers, are needed to enable a more defined view of the inflammatory potential of a diet and its association with various inflammatory‐based health conditions. The results obtained in the present study indicate the need for the development of anti‐inflammatory dietary interventions for population health protection.

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Is there any association of apolipoprotein E gene polymorphisms with metabolic syndrome in a young population of Croatian origin?

Abstract: Although APOE variants were not confirmed as the risk factor for development of MetS, the APOE alleles were associated with some of the metabolic parameters in young Croatian subjects. The relation of APOE alleles with a concentration of adiponectin and leptin depends on the diet intake.

Cited by 2 publications

References 60 publications

Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians

Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians

Metabolic syndrome and its association with the Dietary Inflammatory Index (DII)^® in a Croatian working population

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Is there any association of apolipoprotein E gene polymorphisms with metabolic syndrome in a young population of Croatian origin?

Abstract: Although APOE variants were not confirmed as the risk factor for development of MetS, the APOE alleles were associated with some of the metabolic parameters in young Croatian subjects. The relation of APOE alleles with a concentration of adiponectin and leptin depends on the diet intake.

Cited by 2 publications

References 60 publications

Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians

Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians

Metabolic syndrome and its association with the Dietary Inflammatory Index (DII)® in a Croatian working population

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Metabolic syndrome and its association with the Dietary Inflammatory Index (DII)^® in a Croatian working population