Is There Any Association Between Hirsutism and Serum Zinc Levels in Adolescents?

Aliyev, Ulvi; Kızılkan, Melis Pehlivantürk; Düzçeker, Yasemin; Kanbur, Nuray; Aycan, Zehra; Akgül, Sinem; Derman, Orhan

doi:10.1007/s12011-020-02086-y

Cited by 4 publications

(8 citation statements)

References 54 publications

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“…However, no association has been found between hirsutism and serum zinc concentration. Changes in LH, FSH and prolactin concentrations were also associated with hormonal imbalances among women with PCOS, although the direction of these changes was not so obvious [ 27 , 46 , 47 , 48 , 50 ] and in some studies statistically insignificant [ 28 , 46 , 47 , 48 , 49 , 50 ], also following supplementation with zinc sulfate [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

“…Women with PCOS often demonstrate hormonal disorders such as hyperandrogenism as well. Such abnormalities were noted by the authors of many studies as significant increases in total testosterone, free testosterone, and dehydroepiandrosterone concentration compared with women without PCOS [27,28,45,46,48] (Table 2), while the effect of zinc supplementation on hormonal balance in women with PCOS, especially on testosterone concentrations, is still unclear ( Table 3). Increased peripheral synthesis of androgens, alongside that in adrenals and ovaries are thought to significantly contribute to hyperandrogenism in PCOS [67].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

“…Moreover, PCOS is associated with a distinct increase in global activity of 5α-reductase and this leads to an enhanced conversion of testosterone to dihydrotestosterone in peripheral target cells, which results in androgen actions [67,68]. Zinc is considered an anti-androgen by inhibiting 5α-reductase and thus decreasing the production of dihydrotestosterone [28,69]. Its other involvement in metabolism of androgens includes inhibiting aromatase (and thus decreasing testosterone transformation into estradiol) and increasing conversion of androstenedione to testosterone [28,30,69,70].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

“…Zinc is considered an anti-androgen by inhibiting 5α-reductase and thus decreasing the production of dihydrotestosterone [28,69]. Its other involvement in metabolism of androgens includes inhibiting aromatase (and thus decreasing testosterone transformation into estradiol) and increasing conversion of androstenedione to testosterone [28,30,69,70]. In addition, it was shown that zinc deficiency disturbed the activity of angiotensin converting enzyme, which seems to be involved in the synthesis of adrenals androgens [71].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

“…Because DNA-binding domain of androgen receptor is a zinc finger protein, zinc can also affect the action of androgens and zinc deficiency was shown to suppress activity of this receptor [30,71]. One of the effects of hyperandrogenism is hirsutism, which was also observed in women with PCOS [28]. However, no association has been found between hirsutism and serum zinc concentration.…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

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The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

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Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

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Section: Resultsmentioning

confidence: 99%

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

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The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

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Is idiopathic hirsutism idiopathic?

Kroon

Heijer

Heijboer

2022

Clinica Chimica Acta

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The Effect of Zinc, Shell, and Fishbone Supplementations on Comb Width and Length of Bangkok Rooster

et al. 2022

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The Bangkok rooster is a prestigious ornamental bird in Indonesia. Zinc and shell have an aromatase blocker effect that results in testosterone elevations. Additionally, fishbone contains rich protein for optimum biological functions. Serum testosterone regulates comb size in the chicken. This study aimed to investigate the effect of natural aromatase blockers and protein in the comb of Bangkok roosters. This experiment divided thirteen Bangkok roosters into control and treatment groups with zinc, fishbone-shell, and fishbone supplementations. The weekly comb lengthening and widening were intervals between week 0 and the measurement week in this study. The results suggested that fishbone and fishbone-shell supplementations escalated the comb lengthening. Fishbone–shell treatment significantly increased the comb lengthening in the second and fourth weeks (p < 0.05). The significant elongation change in the fishbone group only appeared in the second week (p < 0.05). Otherwise, the treatments produced lower comb widening in the roosters. Fishbone and fishbone-shell supplementation significantly caused a lower widening in every measurement week (p < 0.05). This study uncovered the effects of zinc, shell, and fishbone supplementations on reproductive phenotype in Bangkok roosters.

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Is There Any Association Between Hirsutism and Serum Zinc Levels in Adolescents?

Cited by 4 publications

References 54 publications

The Role of Zinc in Selected Female Reproductive System Disorders

The Role of Zinc in Selected Female Reproductive System Disorders

Is idiopathic hirsutism idiopathic?

The Effect of Zinc, Shell, and Fishbone Supplementations on Comb Width and Length of Bangkok Rooster

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