Is there any association between plasma lipid profile and severity of COVID-19?

Rahimi–Bashar, Farshid; Sedighi, Ladan; Shahriary, Alireza; Reiner, Željko; Pourhoseingholi, Mohamad Amin; Mirmomeni, Golshan; Vahedian‐Azimi, Amir; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1016/j.clnesp.2022.04.026

Cited by 2 publications

(2 citation statements)

References 48 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, some studies have reported different findings. For example, Rahimibashar F et al 19 found no significant association between lipid profiles and COVID-19 severity. 4 This discrepancy could be due to differences in study populations, sample sizes, and methods of data analysis.…”

Section: Discussionmentioning

confidence: 99%

Association of serum lipid profile ratios with disease severity and in-hospital outcome of patients with COVID-19

Azad,

Areefin,

Murshed

et al. 2023

Birdem Med J

View full text Add to dashboard Cite

Background: The association of lipid ratios with the severity and hospital outcome of COVID-19 patients has been a topic of interest in the medical community. Lipids, particularly cholesterol and triglycerides, play a significant role in the human body, including cell membrane formation, energy storage and the regulation of various biological processes. The aim of this study was to assess the association of lipid ratio with the severity and hospital outcome of COVID-19 patients. Methods: This observational study was carried out in COVID unit of Bangabandhu Sheikh Mujib Medical University (BSMMU) among hospital admitted COVID patients from March 2021 to February 2022. Results: Total patients were 138 including 65.9% males. Majority (27.5%) were in the 41-50 age group. One third (31.2%) were clinically severe COVID-19. There was overall significant difference of lipid ratio in different severity except LDL/HDL group (p>0.05). The correlation coefficients of disease severity with TC/HDL (rs)=.338, LDL/HDL (rs)=.289 and TG/HDL (rs)=.444. There was significant correlation between disease severity and lipid ratio having moderate correlation with TG/HDL and weak correlation with TC/HDL and LDL/HDL. The correlation coefficients between TC/HDL and hospital outcomes of use/development of rebreather (rs)=.217, HFNC (rs)=.282, ARDS (rs)=.307, arrhythmia (rs) = .201, HDU/ICU (rs)=.200 and ventilator (rs)=.072. There was significant correlation between TC/HDL and development of ARDS, use of rebreather and HFNC and no other significant correlation with other outcomes. The correlation coefficients between LDL/HDL and hospital outcomes of use/development of rebreather (rs)=.211, HFNC (rs)=.132, ARDS (rs)=.286, arrhythmia (rs)=.106, HDU/ICU (rs)=.064 and ventilator (rs)=.028. There was no significant correlation between LDL/HDL and hospital outcomes. The correlation coefficients between TG/HDL and hospital outcomes of use/development of rebreather (rs)=.427, HFNC (rs)=.271, ARDS (rs)=.502, arrhythmia (rs)=.088, HDU/ICU (rs)=.158 and ventilator (rs) =.041. There was significant correlation between TG/HDL and development of ARDS, also with use of rebreather and HFNC. No other significant correlation found with other outcomes. Conclusion: From the findings of this current study, in can be concluded that lipid ratios are associated with disease severity and hospital outcome of COVID-19 patients. There was moderate association between disease severity and TG/HDL and weak association with TC/HDL and LDL/HDL. There was also association between TC/HDL and the development of ARDS and the use of HFNC and between TG/HDL and the development of ARDS, the use of rebreather, and HFNC. BIRDEM Med J 2023; 13(2): 98-102

show abstract

Section: Discussionmentioning

confidence: 99%

Association of serum lipid profile ratios with disease severity and in-hospital outcome of patients with COVID-19

Azad,

Areefin,

Murshed

et al. 2023

Birdem Med J

View full text Add to dashboard Cite

show abstract

“…In most studies, histories of hyperlipidemia and hypercholesterolemia were not associated with increased risk of SARS-CoV-2 infection [ 2 , 3 ] or with worsened outcome [ 4 ], despite contradictory findings [ 5 ]. Curiously, whether past hypertriglyceridemia might be associated with deleterious consequences on the risk or severity of SARS-CoV-2 infection remained unknown.…”

Section: The Relationships Between Serum Lipids and Sars-cov-2 Infectionmentioning

confidence: 99%

Statin Therapy to Improve Outcome of COVID-19 Patients: Useful or Not Useful?

Mégarbane

2022

JPM

View full text Add to dashboard Cite

show abstract

Is there any association between plasma lipid profile and severity of COVID-19?

Cited by 2 publications

References 48 publications

Association of serum lipid profile ratios with disease severity and in-hospital outcome of patients with COVID-19

Association of serum lipid profile ratios with disease severity and in-hospital outcome of patients with COVID-19

Statin Therapy to Improve Outcome of COVID-19 Patients: Useful or Not Useful?

Contact Info

Product

Resources

About