Is there any association between contrast-induced nephropathy and serum uric acid levels?

Mirbolouk, Fardin; Arami, Samira; Gholipour, Mahboobeh; Khalili, Yasaman; Modallalkar, Seyedeh Shiva; Naghshbandi, Mona

doi:10.34172/jcvtr.2021.20

Cited by 3 publications

(5 citation statements)

References 39 publications

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“…The analysis of 10 of 15 included studies showed that the incidence rate of PC-AKI in the hyperuricemia group was significantly higher than that in the normal uric acid group ( 10 , 18 , 19 , 21 – 24 , 27 – 29 ). On the contrary, other 5 studies indicated that hyperuricemia was not directly related to the incidence of contrast-induced nephropathy ( 11 , 13 , 20 , 25 , 26 ). The results of the subgroup analysis showed that the overall effect of hyperuricemia was statistically significant, which proved that hyperuricemia was an independent risk factor of PC-AKI, and this is consistent with most of the previously reported results ( 22 – 24 , 27 – 29 ).…”

Section: Discussionmentioning

confidence: 93%

“…Hyperuricemia was associated with PC-AKI and suggested that serum uric acid level could be a novel independent predictor of PC-AKI ( 10 , 11 ). However, similar studies were conducted, while controversial results were reported ( 12 , 13 ), and the causal role in AKI remains elusive. Notably, the relevant studies were mainly conducted based on a direct comparison of the uric acid level between the PC-AKI group and the non- PC-AKI group ( 12 ).…”

Section: Introductionmentioning

confidence: 95%

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Predictive Value of Hyperuricemia in Cardiac Patients with Post-Contrast Acute Kidney Injury (PC-AKI) and Different Basic Renal Functions: A Meta-Analysis

Cai¹,

Zhou²

2022

ijph

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Background: Uric acid level has shown a certain relationship with the incidence of post-contrast acute kidney injury (PC-AKI), whereas it remains controversial whether hyperuricemia can function as a predictor of PC-AKI in patients with different basic creatinine serum level. The present meta-analysis aimed to investigate whether hyperuricemia is an independent risk factor for PC-AKI and to explore the relationship between hyperuricemia and basic renal function. Methods: Relevant studies were retrieved via searching in PubMed, Embase, Cochrane Library, and WAN FANG electronic databases from inception to Jan 2022. Only studies published in English and Chinese languages were selected. Results: Overall, 11892 patients from 15 studies were included. The results of the pooled analysis revealed that the incidence of PC-AKI was significantly higher in the hyperuricemia group than that in the normouricemic group (20.62% vs. 13.05%). Hyperuricemia was associated with an increased risk of the incidence of PC-AKI (odds ratio (OR): 2.48 [95% confidence interval (CI): 1.77-3.46%]). The pooled ORs for mortality and incidence of undergoing renal replacement therapy were 2.33 (95% CI:1.81-3.00) and 8.69 (95% CI:3.22-23.44%), respectively. Comparatively, the pre-existing renal dysfunction subgroup had a lower relative risk in the hyperuricemia population. Conclusion: Hyperuricemia was found to be significantly associated with the incidence of PC-AKI. The effect of serum uric acid level on the incidence of PC-AKI was higher in patients with normal renal function, which could lay a foundation for the establishment of individualized schemes to prevent PC-AKI by urate-lowering therapy.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 95%

Predictive Value of Hyperuricemia in Cardiac Patients with Post-Contrast Acute Kidney Injury (PC-AKI) and Different Basic Renal Functions: A Meta-Analysis

Cai¹,

Zhou²

2022

ijph

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“…Nevertheless, other studies reported conflicting findings. In a study of 211 patients admitted to the hospital for elective coronary angiography or angioplasty, Mirbolouk et al [10] found that the occurrence of contrast-induced nephropathy was not significantly different in patients with normal and high uric acid. Moreover, Pakfetrat et al [11] noted that SUA levels did not significantly differ between those with and without contrast-related AKI.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies show that increased serum uric acid (SUA) induces AKI in patients undergoing primary percutaneous coronary intervention [6][7][8][9]. Nonetheless, other studies indicate that high uric acid is not associated with AKI in low-risk patients undergoing elective PCI [10,11]. The severity of the disease potentially influences the relationship between hyperuricemia and AKI.…”

Section: Introductionmentioning

confidence: 99%

Interaction between Hyperuricemia and Admission Lactate Increases the Risk of Acute Kidney Injury in Patients with ST-Segment Elevation Myocardial Infarction

Wang

Zhou

et al. 2022

Cardiorenal Med

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Background and Objective: Acute kidney injury (AKI) is a common complication associated with adverse outcomes among patients with ST-segment elevation myocardial infarction (STEMI). This is conflicting information about the relationship between hyperuricemia and AKI in STEMI. This work aims to investigate the effect of the interaction between hyperuricemia and lactate on the risk of AKI. Methods: We analyzed 2,008 consecutive STEMI patients between January 2014 and January 2019. Hyperuricemia was defined as a serum uric acid (SUA) level >7 mg/dl for males and >6 mg/dl for females. AKI was defined based on the Kidney Disease: Improving Global Outcomes (KDIGO). Logistic regression models were applied to establish the relationship between hyperuricemia and AKI in the overall population and subgroups stratified as per lactate levels at admission (≤ 2.2 mmol/L or > 2.2 mmol/L). Results: In total, we included 1,887 STEMI patients. Multivariate analysis showed that hyperuricemia is associated with the risk of AKI (OR: 1.34; 95% CI: 1.01-1.77; P =0.045). Nonetheless, the predictive effect of hyperuricemia was only observed in patients with lactate level > 2.2mmol/L (OR: 2.05; 95% CI: 1.36-3.10; P < 0.001), but not in those with lactate level ≤ 2.2mmol/L (OR: 0.86, 95% CI: 0.56-1.32, P = 0.493). The interaction between hyperuricemia and lactate levels demonstrated a significant effect on AKI. Conclusions: In summary, hyperuricemia increases the risk of AKI in STEMI patients with lactate levels> 2.2mmol/L, but not those with lactate levels ≤ 2.2 mmol/L.

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“…Mirbolouk et al, 18 carried out a comprehensive review and meta-analysis to evaluate the influence of the location of myocardial infarction on the risk of CIN. They discovered that patients who experienced anterior myocardial infarctions faced an elevated likelihood of developing contrast-induced nephropathy (CIN).…”

Section: Variablesmentioning

confidence: 99%

Exploring the correlation between radial artery access and decreased occurrence of contrast-induced nephropathy.

Syed Kashif ur Rahman,

Muhammad Abbas Khan,

Muzafar Ali Surhio

et al. 2024

TPMJ

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Objective: To Investigate the Impact of Radial Artery Access on Contrast-Induced Nephropathy (CIN) Incidence. Study Design: Retrospective study. Setting: Department of Cardiology, Hayatabad Medical Complex in Peshawar. Period: January 2021 to June 2022. Material & Methods: Patients aged ≥ 30 who have undergone cardiac catheterization procedures, with a focus on those who have undergone the procedure using radial artery access. Those patients who had pre-existing renal impairments or kidney diseases, with a history of contrast allergies, were included in the study. However, those patients who were under the age of < 30, had undergone cardiac catheterization procedures using femoral artery access, and with incomplete medical records were excluded. All the data were analyzed in SPSS version 26. Results: In our study involving 164 participants. Individuals who experienced CIN exhibited a considerably greater average age of 69.89 years when contrasted with the 66.86 years of those in the non-CIN category (p=0.03). Furthermore, a higher percentage of patients in the CIN group were aged 65 or older (35.1% vs. 11%, p<0.001), highlighting the increased vulnerability of older individuals to CIN. The timing of reperfusion therapy, indicated by the time-to-reperfusion, was significantly longer in the CIN group (6.2 ± 3.3 hours) compared to the non-CIN group (4.9 ± 3.7 hours, p=0.001), suggesting that delayed reperfusion may be a risk factor for CIN. Conclusion: Patients with anterior infarction, delayed reperfusion, lower left ventricular ejection fraction (LVEF), and higher serum creatinine levels were also more likely to develop CIN.

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Is there any association between contrast-induced nephropathy and serum uric acid levels?

Cited by 3 publications

References 39 publications

Predictive Value of Hyperuricemia in Cardiac Patients with Post-Contrast Acute Kidney Injury (PC-AKI) and Different Basic Renal Functions: A Meta-Analysis

Predictive Value of Hyperuricemia in Cardiac Patients with Post-Contrast Acute Kidney Injury (PC-AKI) and Different Basic Renal Functions: A Meta-Analysis

Interaction between Hyperuricemia and Admission Lactate Increases the Risk of Acute Kidney Injury in Patients with ST-Segment Elevation Myocardial Infarction

Exploring the correlation between radial artery access and decreased occurrence of contrast-induced nephropathy.

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