Is there an association between immunosuppressant therapy medication adherence and depression, quality of life, and personality traits in the kidney and liver transplant population?

Gorevski, E.; Succop, Paul; Sachdeva, Jyoti; Cavanaugh, Teresa M.; Volek, Paul; Heaton, Pamela; Chisholm-Burns, Marie A.; Martin-Boone, Jill E.

doi:10.2147/ppa.s34945

Cited by 19 publications

(20 citation statements)

References 26 publications

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“…Contrary to our expectations, we did not find associations between non-adherence and both depression and anxiety, although several studies suggest associations between non-adherence and depression ( 1 , 3 , 6 , 8 , 25 , 28 – 34 ) as well as non-adherence and anxiety ( 1 , 3 , 8 ). In this study, 63.9% of the patients exhibited clinically relevant anxiety symptoms (HADS anxiety score, >10), which is much higher than the proportion found in the study of Weng et al ( 30 ) (6.0% with HADS anxiety score, >10).…”

Section: Discussioncontrasting

confidence: 99%

“…Until today, non-adherence after renal organ transplantation has been shown to be associated with anxiety ( 1 , 3 , 8 ), poor social support ( 1 , 3 , 19 – 23 ), poor quality of life ( 7 , 10 , 24 ), attitudes and beliefs regarding immunosuppressive medication ( 7 – 9 , 25 – 27 ), and depressive symptoms ( 1 , 3 , 6 , 8 , 25 , 28 – 34 ), which are present in approximately 25% of renal transplant recipients ( 28 ). Yet, there are also studies with non-significant results regarding non-adherence and depression ( 25 , 27 , 30 ), anxiety ( 30 ), attitudes and beliefs regarding immunosuppressive medication ( 35 , 36 ), and social support ( 27 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

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Psychosocial Variables Associated with Immunosuppressive Medication Non-Adherence after Renal Transplantation

et al. 2018

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IntroductionNon-adherence to immunosuppressive medication is regarded as an important factor for graft rejection and loss after successful renal transplantation. Yet, results on prevalence and relationship with psychosocial parameters are heterogeneous. The main aim of this study was to investigate the association of immunosuppressive medication non-adherence and psychosocial factors.MethodsIn 330 adult renal transplant recipients (≥12 months posttransplantation), health-related quality of life, depression, anxiety, social support, and subjective medication experiences were assessed, and their associations with patient-reported non-adherence was evaluated.Results33.6% of the patients admitted to be partially non-adherent. Non-adherence was associated with younger age, poorer social support, lower mental, but higher physical health-related quality of life. There was no association with depression and anxiety. However, high proportions of clinically relevant depression and anxiety symptoms were apparent in both adherent and non-adherent patients.ConclusionIn the posttransplant follow-up, kidney recipients with lower perceived social support, lower mental and higher physical health-related quality of life, and younger age can be regarded as a risk group for immunosuppressive medication non-adherence. In follow-up contacts with kidney transplant patients, physicians may pay attention to these factors. Furthermore, psychosocial interventions to optimize immunosuppressive medication adherence can be designed on the basis of this information, especially including subjectively perceived physical health-related quality of life and fostering social support seems to be of importance.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Psychosocial Variables Associated with Immunosuppressive Medication Non-Adherence after Renal Transplantation

et al. 2018

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“…These findings should be confirmed with a larger cohort. Second, our study did not provide insights into potential mechanisms underlying the relationship between psychological function and survival, such as medication adherence (29,39), inflammation (40,41), or physical activity levels (42–44). Future studies should include more comprehensive, serial assessments of medication adherence, functional status, physical activity, and other biomarkers of risk following transplantation.…”

Section: Discussionmentioning

confidence: 93%

Psychosocial Predictors of Mortality Following Lung Transplantation

Smith

Blumenthal

Trulock

et al. 2016

American Journal of Transplantation

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Lung transplantation has become an increasingly common treatment for patients with end-stage lung disease. Few studies have examined psychosocial risk factors for mortality in transplant recipients, despite evidence suggesting that elevated levels of negative affect are associated with greater mortality following major cardiac surgery. We therefore examined the relationship between negative affect early after lung transplantation and long-term survival in a sample of 132 lung transplant recipients (28 cystic fibrosis, 64 chronic obstructive pulmonary disease, 26 idiopathic pulmonary fibrosis, 14 other) followed for up to 13.5 years (median 7.4 years) following transplantation. Patients underwent both medical and psychosocial assessments 6 months following transplantation, which included the Beck Depression Inventory–II (BDI-II), Spielberger Anxiety Inventory, and General Health Questionnaire (GHQ). Over the course of follow-up, 80 (61%) participants died. Controlling for demographic factors, native lung disease, disease severity, family income, education level, social support, and frequency of posttransplant rejection, elevated symptoms of depression (BDI-II: HR = 1.31, p = 0.011) and distress (GHQ: HR = 1.28, p = 0.003) were associated with increased mortality. Higher levels of depression and general distress, but not anxiety, measured 6 months following lung transplantation are associated with increased mortality, independent of background characteristics and medical predictors.

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“…[ 2 ] WHO estimates the cost impact of medication non-adherence in solid organ transplantation to be $15–100 million annually. [ 14 ]…”

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confidence: 99%

Adherence and treatment satisfaction in liver transplant recipients

Albekairy

Alkatheri

Jarab

et al. 2016

Saudi J Gastroenterol

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Background/Aims:Liver transplantation (LT) is a life-saving intervention for patients with liver failure. LT recipients' adherence to their therapeutic regimen is an essential element for graft survival. According to WHO, the impact of medication non-adherence in solid organ transplantation has shown to cost $15–100 million annually. The aim of the present study was to identify the factors that best predict medication adherence and to explore the relationship between treatment satisfaction and medication adherence in liver transplant recipients.Patients and Methods:Adult liver transplant patients at King Abdulaziz Medical City were included in the study. Patients completed the 8-item Morisky Medication Adherence Scale (MMAS-8) and the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4) in addition to several socio-demographic and transplant-related data.Results:A total of 154 patients were included in the study and of these 59.7% were adherent. Older age was a significant predictor of adherence (P < 0.05). The mean treatment satisfaction score was 91.9 ± 12.7 in Effectiveness, 80.0 ± 25.9 in Side Effects, 83.5 ± 15.7 in Convenience, and 94.6 ± 8.6 in Global Satisfaction. Further analysis indicated that patients in the adherent group had reported significantly higher satisfaction scores than those in the non-adherent group (P < 0.05) in all treatment satisfaction domains: Effectiveness (94.4 ± 10.4 vs. 88.6 ± 14.8), Side Effects (83.9 ± 22.0 vs. 74.2 ± 30.1), Convenience (87.0 ± 13.9 vs. 77.2 ± 16.1), and Global Satisfaction (96.9 ± 6.6 vs. 91.2 ± 8.6).Conclusion:Older patients and those who were more satisfied with their treatment tend to have better adherence to the prescribed medications. Therefore, increasing patients' satisfaction with their treatment should be an integral element of future care plans designed to improve treatment outcomes in liver transplant recipients.

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Is there an association between immunosuppressant therapy medication adherence and depression, quality of life, and personality traits in the kidney and liver transplant population?

Cited by 19 publications

References 26 publications

Psychosocial Variables Associated with Immunosuppressive Medication Non-Adherence after Renal Transplantation

Psychosocial Variables Associated with Immunosuppressive Medication Non-Adherence after Renal Transplantation

Psychosocial Predictors of Mortality Following Lung Transplantation

Adherence and treatment satisfaction in liver transplant recipients

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