Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

Arslan, Emine; Görkem, Ümit; Toğrul, Cihan

doi:10.21613/gorm.2019.946

Cited by 14 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical observations have indicated that kisspeptin concentration in GDM women is lower both in the second and third trimester of pregnancy compared to those without GDM (second trimester: 4.51 ± 3.18 (GDM) vs. 10.33 ± 2.65 (controls) nmol/L; third trimester: 11.64 ± 7.65 (GDM) vs. 20.48 ± 7.60 (controls) nmol/L) [ 68 ]. These results are contrary to those obtained by Arslan et al, who have shown no differences in the kisspeptin levels in women with GDM and healthy ones [ 67 ]. A different research methodology could partially explain distinctions among the obtained results.…”

Section: Role Of Kisspeptin In Gestational Diabetes Mellitus—a Placen...contrasting

confidence: 99%

“…The available data that analyzed changes in kisspeptin levels in patients with GDM compared to healthy pregnant women are limited to only a few clinical studies [ 10 , 11 , 64 , 67 , 68 , 69 ]. It has been reported that women with GDM had significantly lower plasma kisspeptin levels compared to healthy ones [ 64 ].…”

Section: Role Of Kisspeptin In Gestational Diabetes Mellitus—a Placen...mentioning

confidence: 99%

See 1 more Smart Citation

The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review

Szydełko-Gorzkowicz

Poniedziałek‐Czajkowska

Mierzyński

et al. 2022

IJMS

View full text Add to dashboard Cite

Kisspeptins are the family of neuropeptide products of the KISS-1 gene that exert the biological action by binding with the G-protein coupled receptor 54 (GPR54), also known as the KISS-1 receptor. The kisspeptin level dramatically increases during pregnancy, and the placenta is supposed to be its primary source. The role of kisspeptin has already been widely studied in hypogonadotropic hypogonadism, fertility, puberty disorders, and insulin resistance-related conditions, including type 2 diabetes mellitus, polycystic ovary syndrome, and obesity. Gestational diabetes mellitus (GDM), preeclampsia (PE), preterm birth, fetal growth restriction (FGR), or spontaneous abortion affected 2 to 20% of pregnancies worldwide. Their occurrence is associated with numerous short and long-term consequences for mothers and newborns; hence, novel, non-invasive predictors of their development are intensively investigated. The study aims to present a comprehensive review emphasizing the role of kisspeptin in the most common pregnancy-related disorders and neonatal outcomes. The decreased level of kisspeptin is observed in women with GDM, FGR, and a high risk of spontaneous abortion. Nevertheless, there are still many inconsistencies in kisspeptin concentration in pregnancies with preterm birth or PE. Further research is needed to determine the usefulness of kisspeptin as an early marker of gestational and neonatal complications.

show abstract

Section: Role Of Kisspeptin In Gestational Diabetes Mellitus—a Placen...contrasting

confidence: 99%

Section: Role Of Kisspeptin In Gestational Diabetes Mellitus—a Placen...mentioning

confidence: 99%

The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review

Szydełko-Gorzkowicz

Poniedziałek‐Czajkowska

Mierzyński

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…We observed no significant differences in gestation-specific kisspeptin levels in pregnancies affected by GDM; however, the gestation adjusted kisspeptin levels from all trimesters were lower than in control pregnancies. Previous data thus far are inconclusive, with 2 studies reporting lower second- and third-trimester plasma kisspeptin levels in women with GDM than in controls ( 15 , 23 ), while another reported no differences ( 56 ). Nonetheless, kisspeptin has been proposed to play a significant role in beta-cell adaptation to the pregnant state ( 23 ).…”

Section: Discussionmentioning

confidence: 96%

Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications

Abbara

Al‐Memar

Phylactou

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Context Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all three trimesters in women with antenatal complications. Objective To assess whether kisspeptin levels are altered in women with antenatal complications. Design Women with antenatal complications (n=105) and those with uncomplicated pregnancies (n=265) underwent serial ultrasound scans and blood-sampling at least once during each trimester (March 2014 to March 2017). Setting Early Pregnancy Assessment Unit at Hammersmith Hospital, UK. Participants Women with antenatal complications: HDP (n=32), FGR (n=17), GDM (n=35) and PTB (n=11), and 10 women with multiple complications, provided 373 blood samples, and a further 265 controls provided 930 samples. Main outcome Differences in circulating kisspeptin levels. Results Third trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking and parity were increased by 30% (95%CI 16-47%; p<0.0001), and of FGR were reduced by 28% (95%CI 4-46%; p=0.025), for every 1 nmol/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (p=0.014), and lower in those affected by GDM (p=0.020), but not significantly on multivariable analysis. Conclusion We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications.

show abstract

“…Kisspeptin concentrations decreased in pregnant women at 16-20 gestational weeks who had placentovascular pathologies, including preeclampsia and intrauterine growth restriction 27 . Cetovic et al 28 also reported markedly lower kisspeptin concentrations in pregnant women with type 1 diabetes, gestational diabetes, and gestational hypertensive disorders, despite other studies demonstrating opposing findings 29 . In another study, serum kisspeptin concentrations in the first trimester were lower in pregnant women who subsequently developed small-for-gestational-age fetuses 30 .…”

Section: Discussionmentioning

confidence: 95%

Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

Görkem¹,

Kan²,

Bostanci³

et al. 2021

MMJ

View full text Add to dashboard Cite

Objective: Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester. Method: In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels. Results: There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all) Conclusions: We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy

show abstract

Is There An Association Between Kisspeptin Levels And Gestational Diabetes Mellitus?

Cited by 14 publications

References 29 publications

The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review

The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review

Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications

Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

Contact Info

Product

Resources

About