Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

Vermey, Belinda G.; Chua, Su Jen; Zafarmand, Mohammad Hadi; Wang, Rui; Longobardi, Salvatore; Cottell, Evelyn; Beckers, F.; Mol, Ben W.; Venetis, Christos A.; D’Hooghe, Thomas

doi:10.1016/j.rbmo.2019.06.013

Cited by 40 publications

(24 citation statements)

References 49 publications

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“…They also showed that the number of oocytes was positively correlated with pregnancy and implantation rates. A recent meta-analysis demonstrated that the number of total oocytes had strong positive associations with the presence of top- or good-quality day-2, day-3, day-5, and day-6 embryos [ 19 ]. In IVF cycles, it is important to obtain at least one good-quality embryo, but the quality of surplus embryos from the same oocyte retrieval cohort is also important.…”

Section: Discussionmentioning

confidence: 99%

Optimal numbers of mature oocytes to produce at least one or multiple top-quality day-3 embryos in normal responders

Shim

Hong

Kim

et al. 2020

Clin Exp Reprod Med

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Objective: We attempted to identify the optimal cutoff numbers of mature oocytes that would produce at least one or multiple top-quality (grade A) day-3 embryos in normal responders undergoing stimulated in vitro fertilization (IVF) cycles.Methods: We selected 210 fresh IVF cycles performed in 170 infertile women at a single center from January 2014 to November 2019. Four to 14 (total) oocytes were obtained in all cycles after conventional ovarian stimulation. A receiver operating characteristic curve analysis was performed to find the moderate and extreme cutoff numbers of mature oocytes that would produce ≥ 1, ≥ 2, ≥ 3, ≥ 4, and ≥ 5 top-quality embryos.Results: The cutoff number of mature oocytes was significantly correlated with the number of top-quality embryos (r = 0.467, p= 0.000). The moderate cutoff number of mature oocytes was ≥ 3, ≥ 5, ≥ 5, ≥ 6, and ≥ 6 for obtaining ≥ 1, ≥ 2, ≥ 3, ≥ 4, and ≥ 5 top-quality embryos, respectively. The extreme cutoff number of mature oocytes was ≥ 9, ≥ 9, ≥ 10, ≥ 10, and ≥ 11 for obtaining ≥ 1, ≥ 2, ≥ 3, ≥ 4, and ≥ 5 top-quality embryos, respectively.Conclusion: We present the optimal cutoff numbers of mature oocytes that would yield ≥ 1, ≥ 2, ≥ 3, ≥ 4, and ≥ 5 top-quality embryos with 95% specificity. Our findings could help infertility clinicians to set target mature oocyte numbers in women undergoing stimulated IVF cycles.

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Section: Discussionmentioning

confidence: 99%

Optimal numbers of mature oocytes to produce at least one or multiple top-quality day-3 embryos in normal responders

Shim

Hong

Kim

et al. 2020

Clin Exp Reprod Med

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show abstract

“…Ultimately, individualised treatment aimed at optimising FORT and FOI will reveal the highest number of oocytes attainable for each cycle and each patient. This in turn could increase the probability of live birth because oocyte number is positively correlated with the number of good quality embryos ( Vermey et al , 2019 ). Lastly, given that the probability of live birth is also related to endometrial receptivity, it is important to evaluate if and how different gonadotropin regimens affect endometrial receptivity, how the luteal phase can be effectively supported in women with potential LH and FSH deficiency ( Revel, 2012 ), and when a freeze all strategy with subsequent frozen embryo transfer cycles is superior to embryo transfer in a fresh cycle with respect to efficacy and safety.…”

Section: Understanding Lh and Fsh Deficiency In Mar: Where Do We Stand? Limitations And Implications For Future Researchmentioning

confidence: 99%

Reduced FSH and LH action: implications for medically assisted reproduction

et al. 2021

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Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles in follicle development and ovulation via a complex interaction in the hypothalamus, anterior pituitary gland, reproductive organs, and oocytes. Impairment of the production or action of gonadotropins causes relative or absolute LH and FSH deficiency that compromises gametogenesis and gonadal steroid production, thereby reducing fertility. In women, LH and FSH deficiency is a spectrum of conditions with different functional or organic causes that are characterized by low or normal gonadotropin levels and low oestradiol levels. While the causes and effects of reduced LH and FSH production are very well known, the notion of reduced action has received less attention by researchers. Recent evidence shows that molecular characteristics, signalling as well as ageing, and some polymorphisms negatively affect gonadotropin action. These findings have important clinical implications, in particular for medically assisted reproduction in which diminished action determined by the afore-mentioned factors, combined with reduced endogenous gonadotropin production caused by GnRH analogue protocols, may lead to resistance to gonadotropins and, thus, to an unexpected hypo-response to ovarian stimulation. Indeed, the importance of LH and FSH action has been highlighted by the International Committee for Monitoring Assisted Reproduction Technologies (ICMART) in their definition of hypogonadotropic hypogonadism as gonadal failure associated with reduced gametogenesis and gonadal steroid production due to reduced gonadotropin production or action. The aim of this review is to provide an overview of determinants of reduced FSH and LH action that are associated with a reduced response to ovarian stimulation.

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“…Given that each oocyte has pregnancy potential, increased oocyte numbers may logically lead to higher CDR ( 8 ). The reason stems from the overall positive correlation between the numbers of oocytes retrieved and the resulting embryos obtained in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment ( 15 ). Thus, the higher the embryo cohort, the higher the CDR, as more opportunities are available to achieve a pregnancy after transferring fresh and cryopreserved embryos ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

Esteves¹,

Conforti

Sunkara

et al. 2021

Front. Endocrinol.

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The POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria were developed to help clinicians identify and classify low-prognosis patients undergoing assisted reproductive technology (ART) and provide guidance for possible therapeutic strategies to overcome infertility. Since its introduction, the number of published studies using the POSEIDON criteria has increased steadily. However, a critical analysis of existing evidence indicates inconsistent and incomplete reporting of critical outcomes. Therefore, we developed guidelines to help researchers improve the quality of reporting in studies applying the POSEIDON criteria. We also discuss the advantages of using the POSEIDON criteria in ART clinical studies and elaborate on possible study designs and critical endpoints. Our ultimate goal is to advance the knowledge concerning the clinical use of the POSEIDON criteria to patients, clinicians, and the infertility community.

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Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

Cited by 40 publications

References 49 publications

Optimal numbers of mature oocytes to produce at least one or multiple top-quality day-3 embryos in normal responders

Optimal numbers of mature oocytes to produce at least one or multiple top-quality day-3 embryos in normal responders

Reduced FSH and LH action: implications for medically assisted reproduction

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

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