Is There an Association Between Bone Mineral Density and Mammographic Density? A Systematic Review

Lee, Jong Min; Holley, Susan; Appleton, Catherine M.; Toriola, Adetunji T.

doi:10.1089/jwh.2016.5769

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…This interesting observation requires further investigation in larger datasets of women. Additionally, exploratory analysis of bone density found little association with breast density, which is in agreement with previous studies [56].…”

Section: Discussionsupporting

confidence: 91%

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Atakpa

Brentnall

Astley

et al. 2021

Cancers

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We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size.

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Section: Discussionsupporting

confidence: 91%

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Atakpa

Brentnall

Astley

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

Bone Mineral Density and Breast Cancer Incidence and Mortality in Postmenopausal Women: A Long-Term Follow-Up Study

Brozek

Nagel

Ulmer

et al. 2019

Journal of Women's Health

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Is There an Association Between Bone Mineral Density and Mammographic Density? A Systematic Review

Abstract: In this review, we found no evidence of an association between BMD and percent mammographic density.

Cited by 2 publications

References 48 publications

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Bone Mineral Density and Breast Cancer Incidence and Mortality in Postmenopausal Women: A Long-Term Follow-Up Study

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