Is There an Association Between Polypropylene Midurethral Slings and Malignancy?

King, Ashley; Zampini, Anna; Vasavada, Sandip; Moore, Courtenay; Rackley, Raymond R.; Goldman, Howard B.

doi:10.1016/j.urology.2014.07.011

Cited by 16 publications

(5 citation statements)

References 10 publications

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“…Three previous studies, with followup ranging between 3.5 and 6 years, did not demonstrate an association between mesh and subsequent pelvic cancer. 5,18,19 Most recently, Chughtai et al evaluated a state-based cohort of patients treated with pelvic mesh. 5 Approximately 10,000 patients treated with midurethral sling and 2,200 treated with mesh for POP were matched against 2 control cohorts.…”

Section: Discussionmentioning

confidence: 99%

“…12,14 A small body of literature corroborates the lack of association between pelvic mesh and cancer; however, these studies are predominantly single institution-based and are limited by short followup and relatively small sample size. 5,18,19 Herein, we sought to determine if SUI surgery, with or without transvaginal mesh, is associated with the development of pelvic cancer in a large population-based cohort of women. We hypothesized that there would not be an increased risk of malignancy in women undergoing SUI surgery.…”

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confidence: 99%

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confidence: 99%

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Stress Incontinence Surgery Does Not Cause Pelvic Malignancy: A Population-Based Cohort Study

Vigil

Wallis

Zhang³

et al. 2021

Journal of Urology

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Purpose: We sought to determine if stress urinary incontinence surgery (mesh or nonmesh) is associated with the development of pelvic malignancies later in life. Materials and Methods: We performed a retrospective cohort study between January 1, 2002 and October 31, 2015 of all women in Ontario, Canada without a history of pelvic malignancy who underwent an index stress incontinence surgery. The primary outcome was a composite of any pelvic malignancy (including urological and gynecological cancers) following stress incontinence surgery. Secondarily, we considered each cancer individually. A survival analysis using a Cox proportional-hazards model with a 3-level categorical exposure (mesh surgery, nonmesh surgery, and control) was performed. Patients were followed until death, emigration or the study end (October 31, 2017). Results: Of the women 74,968 underwent stress urinary incontinence surgery during the study period. There were 5,505,576 women in the control group. Over a median followup of 8.5 years (IQR, 5.5e11.9), 587 pelvic malignancies occurred in the surgery group. Women who underwent stress incontinence surgery had a reduced risk of pelvic malignancy independent of surgery type, compared to controls (Wald type 3 p <0.001; mesh HR, 0.68 [95% CI, 0.62e0.76]; p <0.0001; nonmesh HR, 0.37 [95% CI, 0.29e0.46]; p <0.0001). The individual pelvic cancers similarly demonstrated a reduced risk of malignancy following stress incontinence surgery. Conclusions: At a median followup of 8.5 years, women had no increased risk of pelvic malignancy following either mesh or nonmesh stress urinary incontinence surgery in a large population-based cohort.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Stress Incontinence Surgery Does Not Cause Pelvic Malignancy: A Population-Based Cohort Study

Vigil

Wallis

Zhang³

et al. 2021

Journal of Urology

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“…Both tumors were attached to the meshes, therefore the authors thought that chronic irritation due to mesh could be a contributory factor for cancerogenesis. King et al studied this subject in a group of 2,361 patients who underwent polypropylene mid-urethral sling placement (213). They detected just one case of bladder cancer and one case of vaginal cancer, and no sarcomas after the sling procedure.…”

Section: Discussionmentioning

confidence: 99%

Hernia and Cancer: The Points Where the Roads Intersect

Kulaçoğlu¹,

Köckerling

2019

Front. Surg.

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Introduction: This review aimed to present common points, intersections, and potential interactions or mutual effects for hernia and cancer. Besides direct relationships, indirect connections, and possible involvements were searched. Materials and Methods: A literature search of PubMed database was performed in July 2018 as well as a search of relevant journals and reference lists. The total number of screened articles was 1,422. Some articles were found in multiple different searches. A last PubMed search was performed during manuscript writing in December 2018 to update the knowledge. Eventually 427 articles with full text were evaluated, and 264 included, in this review. Results: There is no real evidence for a possible common etiology for abdominal wall hernias and any cancer type. The two different diseases had been found to have some common points in the studies on genes, integrins, and biomarkers, however, to date no meaningful relationship has been identified between these points. There is also some, albeit rather conflicting, evidence for inguinal hernia being a possible risk factor for testicular cancer. Neoadjuvant or adjuvant therapeutic modalities like chemotherapy and radiotherapy may cause postoperative herniation with their adverse effects on tissue repair. Certain specific substances like bevacizumab may cause more serious complications and interfere with hernia repair. There are only two articles in PubMed directly related to the topic of “hernia and cancer.” In one of these the authors claimed that there was no association between cancer development and hernia repair with mesh. The other article reported two cases of squamous-cell carcinoma developed secondary to longstanding mesh infections. Conclusion: As expected, the relationship between abdominal wall hernias and cancer is weak. Hernia repair with mesh does not cause cancer, there is only one case report on cancer development following a longstanding prosthetic material infections. However, there are some intersection points between these two disease groups which are worthy of research in the future.

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“…5. Other literature, albeit with shorter average follow-up, has not noted any association between these slings and malignancy [3]. 6.…”

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confidence: 84%

Polypropylene mesh slings and cancer: An incidental finding or association?

Goldman

Dwyer

2015

Int Urogynecol J

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Is There an Association Between Polypropylene Midurethral Slings and Malignancy?

Cited by 16 publications

References 10 publications

Stress Incontinence Surgery Does Not Cause Pelvic Malignancy: A Population-Based Cohort Study

Stress Incontinence Surgery Does Not Cause Pelvic Malignancy: A Population-Based Cohort Study

Hernia and Cancer: The Points Where the Roads Intersect

Polypropylene mesh slings and cancer: An incidental finding or association?

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