Is there adenoma-carcinoma sequence between benign adenoma and papillary cancer of thyroid: A genomic linkage study

Bangaraiahgari, Ramesh; Panchangam, Ramakanth Bhargav; Puthenveetil, Pradeep; Mayilvaganan, Sabaretnam; Bangaraiahgari, Rajesh; Banala, Rajkiran Reddy; Karunakaran, Poongkodi; Rafi,

doi:10.1016/j.amsu.2020.11.069

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…None of these theories is completely able to explain the origin of collision tumors as there is not enough evidence and literature. 10 Treatment of collision tumour is challenging as there is no study on patient's prognosis and survival. Multimodal treatment is recommended to the most aggressive tumor with higher stage among the two.…”

Section: Discussionmentioning

confidence: 99%

Dual lesions in thyroidectomy, unravelling the enigma of thyroid collision tumors: A rare case report

Hegde,

Mirza,

Shankar

2024

IJPO

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Follicular adenoma (FA) of the thyroid gland is a benign, solitary, encapsulated tumor. It shows microfollicular and macrofollicular growth patterns. Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy and follicular variant is the most common subtype of PTCs. They have tumor cells arranged in follicular pattern which exhibit nuclear features of papillary carcinoma. Here we present a remarkable case of a patient who was clinically diagnosed as multinodular goiter, TIRADS 2 (not suspicious) by ultrasonography and Fine needle aspiration cytology report was given as a benign adenomatoid nodule. However, histopathological examination revealed the unexpected coexistence of both follicular adenoma and PTC.

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Section: Discussionmentioning

confidence: 99%

Dual lesions in thyroidectomy, unravelling the enigma of thyroid collision tumors: A rare case report

Hegde,

Mirza,

Shankar

2024

IJPO

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“…This case is very specific, because we describe completely separate synchronous papillary and medullary carcinomas. The origin and biology of synchronous papillary-medullary thyroid carcinomas are not completely understood; however, leading theories include stem cell theory, collision effect theory, and hostage theory ( 27 , 28 ). The stem cell theory suggests that the carcinoma originates from a rare population of cancerous stem cells ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

“…Collision effect theory postulates that the mixed carcinoma originates as two distinct tumor types that initiate near each other resulting in a polyclonal neoplasm that is recognized as a single entity ( 27 ). The “hostage” theory hypothesizes that the carcinoma is a result of adenomatous areas being sequestered by a different type of tumor ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Synchronous papillary-medullary thyroid microcarcinoma: a case report

Medam¹,

Castro²,

Alhassan³

et al. 2022

AME Case Rep

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Background Papillary thyroid carcinoma is the most common type of thyroid carcinoma, making up 85–90% of all thyroid carcinomas. Medullary thyroid carcinoma is the third most common type of thyroid carcinoma, making up less than 5% of all thyroid carcinomas. However, synchronous papillary-medullary thyroid carcinoma is exceedingly rare and has not been well described historically. There have been fewer than 40 cases reported in the current literature. Case Description In this case report we present a 65-year-old man with synchronous papillary-medullary thyroid carcinoma. A 65-year-old man presented with a symptomatic multinodular thyroid goiter. Ultrasound (US) confirmed bilateral thyroid nodules, and he was initially managed nonoperatively. Fine needle aspiration (FNA) biopsy of the left dominant nodule revealed atypia of undetermined significance (AUS) (Bethesda class III). Further assessment of the FNA specimen with ThyGeNEXT ® (mutation panel) revealed no mutations and the ThyraMIR ® (microRNA risk classifier) was negative, which classified the results as very highly likely to be benign. Due to worsening local compressive symptoms, a total thyroidectomy was performed. Final surgical pathology revealed incidental multicentric, multifocal micropapillary carcinoma foci from (0.1 to 0.5 cm), and a 0.3 cm medullary carcinoma in the left thyroid lobe on the background of nodular hyperplasia. Conclusions Synchronous papillary-medullary thyroid carcinoma is a rare finding that should be considered in patients with symptomatic multinodular thyroid goiters. It is important to report this case to increase awareness and improve our understanding and management of these unusual carcinomas in the future.

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“…The leading theories include the collision effect, stem cell and hostage theory. The hostage theory hypothesizes that carcinoma is attributable to adenomatous areas becoming sequestered by a different type of tumor (29). The stem cell theory hypothesizes that the tumor originates from the same stem cell and differentiates into two distinct types of carcinoma cells (30).…”

Section: Surgical Managementmentioning

confidence: 99%

Mixed medullary‑follicular thyroid carcinoma: A case report and literature review

Wang,

Yin,

Ren

et al. 2023

Oncol Lett

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Papillary thyroid cancer (PTC) and medullary thyroid cancer (MTC) originate from follicular and neuroendocrine parafollicular C cells, respectively. PTC and MTC simultaneously exist in tumors containing both MTC and PTC features in a rare condition known as mixed medullary-follicular thyroid carcinoma (MMFTC). In the present study, a 60-year-old female presented with a small mass on the left side of the neck. Ultrasonography indicated a hyperechoic nodule measuring ~11.9x9.7 mm 2 in the left lobe of the thyroid gland. The preoperative calcitonin serum value was elevated and total thyroidectomy and bilateral central compartment lymph node dissection was performed. Histological and immunohistochemical analysis of the tumor demonstrated MMFTC. No metastasis was observed in lymph nodes isolated from the bilateral central compartment. Given the rarity of MMFTC, enhancing understanding and management of such tumors is crucial.

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Is there adenoma-carcinoma sequence between benign adenoma and papillary cancer of thyroid: A genomic linkage study

Cited by 8 publications

References 34 publications

Dual lesions in thyroidectomy, unravelling the enigma of thyroid collision tumors: A rare case report

Dual lesions in thyroidectomy, unravelling the enigma of thyroid collision tumors: A rare case report

Synchronous papillary-medullary thyroid microcarcinoma: a case report

Mixed medullary‑follicular thyroid carcinoma: A case report and literature review

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