Is There a Role for Spirulina Platensis against Reprotoxicity and Oxidative Stress Induced by Gamma Irradiation in Rats?

Arab, Aliaa Ezz El; Abbas, Osama A.; Abdel-Gawad, Eman I.

doi:10.12691/jfnr-7-5-7

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…This effect is attributed to SP because it has effects that work on the production of testo, which is the main androgen in the testicle, in Leydig cells, which directly depends on the stimulation of testicular hormone (LH), which stimulates muscle growth and sexual activity [19]. The results of the study didn't agree with [20,21,22] who showed that spirulina did not significantly affect the level of interstitial cell-stimulating hormones (LH and FSH) in laboratory animals, pigs, and goats for a period of 60 days.…”

Section: Effect Of Adding Protein and Spirulina Algae On Hormones In ...mentioning

confidence: 91%

Effects of ICSH Hormone and Testosterone by Adding Spirulina Platensis to the Feed with Different Protein Levels in Local Male Sheep

Yas Khudair,

Alwan Hamad

2024

IOP Conf. Ser.: Earth Environ. Sci.

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This study was carried out in the animal field of the College of Veterinary Medicine at Tikrit University, and continued for 90 days from 10/2/2022 to 12/31/2022, using two levels of spirulina platensis (SP), 8 and 12%, to raise the value of the diet with low protein (LP) content, as well as reducing the harmful effect of high protein (HP) on the other hand in lamb diets and to investigate the effect of two levels using some hormones and longitudinal measurements of the reproductive system related to reproductive activity of Iraqi lambs. 24 local lambs were used, purchased from the markets of Saladin Governorate - Iraq, and their ages ranged between 3 and 4 months, with an average starting weight of 20.5 ± 0.9 kg, by randomly distributing them into 6 treatments / 4 lambs for each treatment. As follows: The first treatment was HP (control 1). The second treatment was HP + 8 g SP/1 kg concentrated feed. The third treatment was HP + 12 g SP/1 kg concentrated feed. The fourth treatment was LP (control 2) and the fifth treatment was LP + 8 g SP/1 kg feed. Concentrate and the sixth treatment, LP + 12 g SP/1 kg concentrated feed. The results of the study indicated that there were significant differences (P<0.05) in the levels of interstitial-cell stimulating hormone (ICSH) and testosterone (Testo) when adding LP on day 90. On the other hand, adding spirulina at a level of 12 g caused a significant effect (P<0.05) on ICSH and Testo on day 45, and on day 90 only Testos was affected. The interaction between HP and SP at a level of 12 grams showed significant differences in ICSH and Testo. Also, the interaction between HP and SP at a concentration of 12 g caused an increase in measurements of both the length, width, and circumference of the testicle. Scrotal height was also affected by the interaction between LP and the 12 g SP concentration.

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Section: Effect Of Adding Protein and Spirulina Algae On Hormones In ...mentioning

confidence: 91%

Effects of ICSH Hormone and Testosterone by Adding Spirulina Platensis to the Feed with Different Protein Levels in Local Male Sheep

Yas Khudair,

Alwan Hamad

2024

IOP Conf. Ser.: Earth Environ. Sci.

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Radiation and male reproductive system: Damage and protection

Guo,

Wang,

Shuai

et al. 2024

Chemosphere

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The Protective Potency of Medemia argun (An Egyptian Palm) Against Oxidative Stress, and Tissue Injury Induced by γ-Radiation in Rats

Abdel-alim

Moussa

El‐Saied

et al. 2022

Preprint

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Radiation damages living cells and affect all biological process in human body. Thereby, there is a magnificent interest for protecting patients from the aspect consequences radiotherapy and specialized professional workers by developing a natural antioxidant bio-drugs for amelioration of radiation hazards. Medemia argun (an Egyptian Palm) is a mysterious from northern Sudan and southern Egypt (Nubian desert oases). In ancient Egypt, Medemia argun (MA) dried dates have found in the famed tomb of Tutankhamun. Globally, this is first study related to the metabolomics and biological efficiency of MA in alleviating the harmful effect of γ-irradiation. This work highlights the ameliorative role of MA ethanolic seed’s extract, as a natural promising functional food ingredient in alleviating radiation hazard via its antioxidative properties, anti-inflammatory, antiapoptoic and cell regeneration abilities. In this search, we have estimated the LD50 of MA ethanolic seed’s extract in vivo using male Wistar albino rats. The obtained results showed that 200 mg/kg b.wt. is the recommended dose. Rats were randomly splited into four groups. Group I: Represent as control (normal rats), that were received normal food and water daily for six weeks. Group II. Rats subjected to gamma radiation (6 Gy), a single dose of whole body after one week of the experiment. Group III. Rats were injected intraperitoneally with 200 mg/kg b.wt. of MA ethanolic seed’s extract twice/week for six weeks. Group IV. Rats subjected to gamma radiation (6 Gy), a single dose of whole body after one week of the experiment, then injected intraperitoneally with MA ethanolic seed’s extract (200 mg/kg b.wt.) twice/week for six weeks. Each group contains 15 rats. γ-radiation treatment caused a significant increase in DNA fragmentation, NO, MDA, inflammatory biomarkers (TNF-α, HsP70, IL-6, IL-10, 8-OH-dG, CASP-3, MPC-1, and MMP-9), and liver function (ALT, AST, GGT, ALP, and AFP). Also, there is a significant decrease in GSH, SOD, CAT, POD, T. protein, and albumin. Conversely, MA (200 mg/Kg b.wt.) treatment for 6 weeks effectively reflects most of the altered measurements induced by γ-radiation. The potent therapeutic efficacy of MA was manifested in repairing the DNA fragmentation induced by γ-irradiation and this improvement confirmed by decrease in the concentration of 8-OH-dG. To assess the biological activities and beneficial effect of the ethanolic extract of MA seed’s in ameliorating the radiation hazards in rats, phytochemical analysis, were estimated which revealed presence of many beneficial natural health compounds such as, polyphenols (phenolics and flavonoids), proanthocyanidin (condensed tannins), saponins, protein and carbohydrate. Furthermore, histopathological examinations showed significant adverse deleterious changes in the structure of liver tissue due to exposure to γ-radiation, while treatment with MA maintains the cellular structure of the liver without the appearance of any changes. Biochemical data came to agree with the histopathological observations. There are no published reports of the radioprotective role of Medemia argun in rats. Our results showed that MA can be used during radiotherapy as a natural therapeutic drug due to its valuable nutritional benefits, safe, nature and low cost.

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Is There a Role for Spirulina Platensis against Reprotoxicity and Oxidative Stress Induced by Gamma Irradiation in Rats?

Cited by 3 publications

References 31 publications

Effects of ICSH Hormone and Testosterone by Adding Spirulina Platensis to the Feed with Different Protein Levels in Local Male Sheep

Effects of ICSH Hormone and Testosterone by Adding Spirulina Platensis to the Feed with Different Protein Levels in Local Male Sheep

Radiation and male reproductive system: Damage and protection

The Protective Potency of Medemia argun (An Egyptian Palm) Against Oxidative Stress, and Tissue Injury Induced by γ-Radiation in Rats

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