Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?

Ferreira, Juliana; Masquio, Deborah Cristina Landi; Campos, Raquel Munhoz da Silveira; Netto, Bárbara Dal Molin; Corgosinho, Flávia Campos; Sanches, Priscila de Lima; Tock, Lian; Tufik, Sérgio; Mello, Marco Túlio de; Finlayson, Graham; Dâmaso, Ana Raimunda

doi:10.1016/j.peptides.2014.11.010

Cited by 28 publications

(42 citation statements)

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“…In our study, we observed an attenuation of hyperleptinemia upon training, in keeping with an improvement of leptin regulation induced by a higher energy expenditure [29, 34]. Associated to the better food intake control in trained HF mice, our data are in accordance with other studies suggesting that exercise training reduces leptin resistance [35–37]. …”

Section: Discussionsupporting

confidence: 91%

Interactions of exercise training and high-fat diet on adiponectin forms and muscle receptors in mice

et al. 2016

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BackgroundMetabolic syndrome (MetS) is characterized by systemic disturbances that increase cardiovascular risk. Adiponectin (Ad) exhibits a cardioprotective function because of its anti-inflammatory and anti-atherosclerotic properties. In the bloodstream, this adipocytokine circulates on multimers (Admer), among which high molecular weight (HMW) are the most active forms. Because alterations of Ad plasmatic levels, Admer distribution and receptor (AdipoR) expression have been described in murine models and obese patients, strategies that aim to enhance Ad production or its effect on target tissues are the subject of intense investigations. While exercise training is well known to be beneficial for reducing cardiovascular risk, the contribution of Ad is still controversial. Our aim was to evaluate the effect of exercise training on Ad production, Admer distribution and AdipoR muscle expression in a murine model of MetS.MethodsAt 6 weeks of age, mice were submitted to a standard (SF) or high-fat high-sugar (HF) diet for 10 weeks. After 2 weeks, the SF- and HF-fed animals were randomly assigned to a training program (SFT, HFT) or not (SFC, HFC). The trained groups were submitted to sessions of running on a treadmill 5 days a week.Results and conclusionsThe HF mice presented the key problems associated with MetS (increased caloric intake, body weight, glycemia and fat mass), a change in Admer distribution in favor of the less-active forms and increased AdipoR2 expression in muscle. In contrast, exercise training reversed some of the adverse effects of a HF diet (increased glucose tolerance, better caloric intake control) without any modifications in Ad production and Admer distribution. However, increased AdipoR1 muscle expression was observed in trained mice, but this effect was hampered by HF diet. These data corroborate a recent hypothesis suggesting a functional divergence between AdipoR1 and AdipoR2, with AdipoR1 having the predominant protective action on metabolic function.Electronic supplementary materialThe online version of this article (doi:10.1186/s12986-016-0138-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Interactions of exercise training and high-fat diet on adiponectin forms and muscle receptors in mice

et al. 2016

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“…Our findings indicate that female patients with MDD have elevated circulating leptin levels compared with depressed males. Leptin, an adipocyte-derived protein, has emerged as a key player in the pro-inflammatory process in obesity and metabolic syndrome and is, therefore, considered a pivotal link in obesity-related diseases ( 36 , 37 ). Prior literature has also suggested a relationship between leptin and depression ( 19 , 20 , 38 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Gender-Specific Relationship between Obesity and Major Depression

Gower

Shelton

et al. 2017

Front. Endocrinol.

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ObjectivePrior research suggests a bidirectional relationship between obesity and major depressive disorder (MDD), but the results have been heterogeneous. Differences between males and females in the association of MDD with obesity may contribute to inconsistent results. Thus, this study was designed to determine whether sex has a differential effect on the relationship between MDD and obesity, and to explore the potential mechanisms.MethodsAll participants were diagnosed with MDD, and depression severity was measured using the 17-item Hamilton Depression Rating Scale. Body weight and height were measured to calculate body mass index (BMI). Body composition, including total fat, trunk fat, android fat, and visceral fat mass, was measured by dual-energy X-ray absorptiometry. Subjects provided blood samples, and serum was extracted for measuring the inflammatory factors using human immunoassay kits.ResultsAmong all obesity measures, depressed women had greater BMI and total body fat. By contrast, depressed men had greater visceral fat mass. However, only in depressed women was depression correlated with several measures of obesity, including BMI, total body fat, and visceral fat mass. A stepwise multiple regression analysis was conducted, and only visceral fat entered the regression model and was most predictive of depression in women (β = 0.60, p = 0.007). Moreover, compared with depressed men, depressed women had higher leptin levels after controlling for BMI, total body fat, and visceral fat.ConclusionThese results highlight gender differences in determining the association between obesity and depression, and elevated leptin level is a potential mechanism linking MDD to obesity in depressed women. Understanding a gender-specific relationship between obesity and MDD would allow clinicians to target and personalize therapies in the hope of improving health outcomes.

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“…Obesity has been characterized as a state of reduced resistance or sensitivity to various hormones, including leptin. Most obese individuals have high serum levels of leptin that are compatible with their adipose mass, suggesting that the mechanism is more a resistance to the action of this hormone than to the lack of it [33][34][35]. This state of hyperleptinemia produces an inadequate response in weight loss therapy and favors the inflammatory process in the constellation of chronic diseases [36].…”

Section: Discussionmentioning

confidence: 99%

“…According to model cognitive [51,52], the depression and anxiety symptoms are products of cognitive distortions. It is believed that interdisciplinary therapy favored the developmental of more flexible and adaptive cognitive patterns that may have attenuated the psychological suffering and effective behavior changes [35,37].…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine Control, Inflammation, and Psychological Aspects After Interdisciplinary Therapy in Obese Women

et al. 2019

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Obesity is a chronic and multifactorial disease promoted by positive energy balance. The objective was to evaluate the effects of interdisciplinary therapy in the neuroendocrine control of food intake, inflammatory markers, and psychological aspects in obese women. Forty-seven obese women (43.32±5.82 years, 34.86±3.08 kg/m2), aged 30–50 years, participated in an interdisciplinary lifestyle change therapy, consisting of nutritional counseling, physical exercises, and psychological therapy for 36 weeks. After the long-term therapy, there was a decrease in body weight (Δ –5.36 kg), BMI (Δ –2.01 kg/m2), abdominal (Δ –9.09 cm), hip (Δ –5.03 cm), and thigh (Δ –5.07 cm) perimeters. There was also a significant improvement in body composition, with an increase in fat-free mass (Δ 1.60%) and reduction of body fat (Δ –3.74 kg). The therapy proposed also provided an improvement in depression scores (Δ –6.63), anxiety (Δ –4.07), body image (Δ –25.25), and binge eating (Δ –5.25). There was a significant reduction in serum levels of leptin (Δ –15.62 ng/ml). The interdisciplinary therapy was able to provide both, physical and psychological benefits in energy balance, which enables the use of this model as a feasible clinical strategy for the treatment of obesity.

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Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?

Cited by 28 publications

References 49 publications

Interactions of exercise training and high-fat diet on adiponectin forms and muscle receptors in mice

Interactions of exercise training and high-fat diet on adiponectin forms and muscle receptors in mice

Gender-Specific Relationship between Obesity and Major Depression

Neuroendocrine Control, Inflammation, and Psychological Aspects After Interdisciplinary Therapy in Obese Women

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