Is there a relationship between blood lipids and lumbar disc herniation in young Turkish adults?

Keser, Neşe; Çelikoğlu, Erhan; İş, Merih; İlgezdi, Zeynep Demet; Sunar, Bendigar; Aydin, Yusuf; Kevenk, Ahmet Uğur; Gürer, Bora; Ramazanoğlu, Ali Fatih; Keser, Nurgül

doi:10.5114/amsad.2017.68651

Cited by 5 publications

(7 citation statements)

References 26 publications

(28 reference statements)

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“…A Finnish study performed by Leino-Arjas [12] et al identified a positive correlation between higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and sciatica. Several studies further demonstrated that triglycerides (TG) and TC were related to the severity of low back pain and symptomatic IDH [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Serum apolipoprotein B/apolipoprotein A1 ratio in relation to intervertebral disk herniation: a cross-sectional frequency-matched case–control study

Chen

Bai

et al. 2021

Lipids Health Dis

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Study design This was a cross-sectional frequency-matched case–control study. Background and aim The serum lipid profile of lipoprotein(a) [Lp(a)] level and apolipoprotein B/apolipoprotein A1 ratio (Apo B/Apo A1) ratio were found to be more representative for serum lipid level and were recognized as the independent risk factors for various diseases. Although the blood levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were found to be associated with symptomatic intervertebral disk herniation (IDH), no studies to date have evaluated the association of Apo AI, Apo B, Lp(a), and Apo B/Apo AI levels with symptomatic IDH. This study aimed to assess the link between blood lipid levels and symptomatic IDH. Method The study included 1839 Chinese patients. Of these, 918 patients were diagnosed with IDH and enrolled in the experimental group. A control group of 921 patients underwent a physical examination during the same period. The serum lipid levels of TC, TG, LDL-C, HDL-C, Lp(a), Apo B, and Apo B/Apo AI were examined and analyzed. The control group comprised randomly selected patients who met the baseline levels of the aforementioned lipid molecules. Results Patients with IDH exhibited significantly higher TC, TG, LDL, Apo B, and Lp(a) levels than controls. The percentage of high TC, high TG, high LDL, high Apo B, and high Lp(a) were obviously higher in the IDH group than in the control group. However, hyperlipidemia had no relationship with the degenerated segment of the IDH (P = 0.201). The odds ratio (OR) for the incidence of IDH with elevated levels of LDL-C, TC, TG, Lp(a), Apo B, and Apo B/Apo AI was 1.583, 1.74, 1.62, 1.58, 1.49, and 1.39, respectively. The correlation analysis revealed the correlation between elevated LDL-C, TC, TG, Apo B, Lp(a), and incidence of IDH was significant (R2LDL = 0.017; R2TC = 0.004; R2TG = 0.015; R2Apo B = 0.004; R2Lp(a) = 0.021) (P < 0.05). Conclusion This study suggested that elevated levels of serum TC, TG, LDL, Apo B, Lp(a), and Apo B/Apo AI were associated with a higher risk of IDH. This study provided useful information to identify a population that might be at risk of developing IDH based on elevated lipid levels.

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Section: Introductionmentioning

confidence: 99%

Serum apolipoprotein B/apolipoprotein A1 ratio in relation to intervertebral disk herniation: a cross-sectional frequency-matched case–control study

Chen

Bai

et al. 2021

Lipids Health Dis

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“…The main mechanisms of diabetes promoting IDD are as follows: when cells are exposed to high glucose, their internal glucose homeostasis is disturbed, which impedes glucose metabolism and affects energy metabolism 16 . High glucose leads to hardening of intervertebral disc endplate cartilage and narrowing of internal microvessels, which reduces the nutrient supply of nucleus pulposus cells and the e ciency of substance exchange with the external environment of cells 17 . A high glucose environment can mediate and accelerate cell aging, impair mitochondrial function, lead to the accumulation of oxidative stress products, and eventually cause apoptosis of intervertebral disc cells.…”

Section: Discussionmentioning

confidence: 99%

Factors of Intervertebral Disc Rehydration after Percutaneous Endoscopic Lumbar Discectomy

Lai

Tan

et al. 2022

Preprint

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Percutaneous endoscopic lumbar discectomy (PELD) is an effective surgical option for lumbar disc herniation (LDH) but is associated with lumbar intervertebral disc rehydration in some patients. However, the incidence of rehydration is not clearly, and only a few studies have discussed this in detail. The study aimed at investigating the factors influencing intervertebral disc rehydration in a series of patients with LDH who underwent PELD. Ninety-six patients with single-level LDH who underwent PELD at Shenzhen Traditional Chinese Medicine Hospital from October 2013 to May 2021 were studied. The relevant data of the patients were recorded such as age, course of disease, sex, body mass index (BMI), diabetes mellitus, hypertension, smoking status, and postoperative exercise; imaging factors such as Modic changes of adjacent vertebrae at surgical level, Pfirrmann grade, degree of disc herniation (Komori classification), and spinal canal morphology; peripheral blood factors such as blood routine parameters, C-reactive protein level, erythrocyte sedimentation rate (ESR), and Th1/Th2 subgroup analysis; and operation-related factors such as surgical approach, length of operation, and amount of blood loss. Univariate analysis and binary logistic regression analysis were conducted to determine the influence of the above parameters on disc rehydration. Our results showed that Young patients with intervertebral disc herniation with a short course of disease, no smoking history, not overweight, no history of diabetes, with intervertebral disc herniation type of Komori Type C, Pfirrmann grade IV, and no adjacent vertebral Modic changes, coupled with high levels of mononuclear cells and TNF-α in peripheral blood, may be more prone to rehydration after PELD.

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“…The frequency of comorbid diseases increases at advanced ages, but their roles in LSS etiology are uncertain. Arterial calcification and atherosclerosis diseases, such as hypertension, dyslipidemia, diabetes mellitus, are considered as risk factors not only for coronary artery diseases but also for spinal degenerative diseases, and their roles in the etiology of low back pain and intervertebral disc herniation have been the subject of many studies in the past years [12][13][14] .…”

Section: Discussionmentioning

confidence: 99%

“…However, in this study, patients are older, and gender distribution is uneven, which reduces the reliability of this study. Menopause and estrogen are hormonal factors that affect blood lipid profile [13,15] . To eliminate the effects of gender on blood lipid profiles, two homogeneous groups of men and women were included in our study.…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between blood lipid profile and lumbar spinal stenosis?

Akar¹

2020

Haydarpasa Numune Med J

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Introduction: The etiology of lumbar spinal stenosis (LSS) is still unknown, but it is a multifactorial disease. Reduced blood flow due to atherosclerosis is thought to accelerate spinal degenerative changes, but it is not known whether there is a relationship between blood lipid profile and the development of spinal stenosis. In this study, we compared the LSS patients who underwent surgery and the patients without narrow canal findings., We aimed to evaluate the role of hyperlipidemia in the etiology of spinal stenosis. Methods: In our study, the blood lipid values (total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol) of two different groups between the ages of 60 and 70, consisting of women and men, were analyzed and compared retrospectively. Group 1 (LSS group) with 40 LSS cases (20 females/20 males) operated in our clinic, Group 2 (control group)with the patients from patients who applied to the outpatient clinic for nonspecific reasons (such as headache). Results: There was no statistically significant difference in Group 1 and Group 2 concerning HDL and LDL levels. The VLDL level of Group 1 was statistically significantly higher than Group 2 (p=0.000; p<0.05). The triglyceride level of Group 1 was statistically significantly higher than Group 2 (p=0.000; p<0.05). Discussion and Conclusion: It is thought that there is a relationship between VLDL and triglyceride levels and the development of spinal stenosis. However, there is no such relationship with HDL and LDL.

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Is there a relationship between blood lipids and lumbar disc herniation in young Turkish adults?

Cited by 5 publications

References 26 publications

Serum apolipoprotein B/apolipoprotein A1 ratio in relation to intervertebral disk herniation: a cross-sectional frequency-matched case–control study

Serum apolipoprotein B/apolipoprotein A1 ratio in relation to intervertebral disk herniation: a cross-sectional frequency-matched case–control study

Factors of Intervertebral Disc Rehydration after Percutaneous Endoscopic Lumbar Discectomy

Is there a relationship between blood lipid profile and lumbar spinal stenosis?

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