Is There a Relationship Between Vitamin D Deficiency Status and PCOS in Infertile Women?

Arslan, Emine; Görkem, Ümit; Toğrul, Cihan

doi:10.1055/a-0871-6831

Cited by 14 publications

(19 citation statements)

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“…Interestingly, the study found an association between VDR polymorphisms and AMH levels in PCOS women, while there was no correlation between AMH and AMHR-II gene polymorphisms and AMH levels [52]. Arslan et al [53] similarly found no correlation between serum AMH and 25OH-D levels in PCOS patients (r = 0.027, p = 0.836) and control individuals (r = −0.112, p = 0.307). This study included 146 Turkish infertile women that were divided into normal ovarian reserve patterns (n = 86) and PCOS ovarian reserve patterns (n = 60).…”

Section: Observational Studiesmentioning

confidence: 84%

“…The current systematic review included eighteen cross-sectional studies and six interventional studies assessing the relationship between serum vitamin D levels and serum AMH levels. The cross-sectional studies demonstrated conflicting results, with several studies finding a positive correlation between serum AMH and vitamin D levels [42,46,50,61], while most studies reported largely negative findings [43][44][45]47,49,[51][52][53][54][55][56][57][58][59]. The systematic review and meta-analysis of the interventional studies revealed that vitamin D supplementations affect serum AMH levels but have opposite effects depending on the ovulatory statuses of the women.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, Bednarska-Czerwińska et al [58] reported a negative correlation between AMH and vitamin D concentrations of up to approximately 30 ng/mL, while beyond that concentration, the trend became positive but statistically insignificant. In addition, differences in the population size may also account for negative findings, as some of the studies had small numbers of patients [43,49,[51][52][53][54]56,58] and were not adequately powered to detect small but significant associations between vitamin D and AMH.…”

Section: Discussionmentioning

confidence: 99%

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The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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Accumulating evidence from animal and human studies indicates a role for vitamin D in female reproductive physiology, and numerous clinical studies have suggested its potential benefit for various aspects of human reproduction. Anti-Müllerian hormone (AMH) is an ovarian biomarker that plays an important role in folliculogenesis. It is the most sensitive ovarian reserve marker and is widely used clinically in reproductive medicine. While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting. Currently, there is considerable debate in the field whether vitamin D has the capacity to influence ovarian reserve, as indicated by the AMH level. The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH. In total, 18 observational studies and 6 interventional studies were included in this systematic review. Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH. However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman’s ovulatory status. Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) −0.53, 95% CI −0.91 to −0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003). In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.

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Section: Observational Studiesmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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“…У той же час дефіцит 25(OH)D та гени пов'язані з низьким рівнем вітаміну мають незначний вплив на індекс маси тіла (ІМТ) [10]. З огляду на високий рівень ожиріння серед жінок зі СПКЯ і той факт, що в загальній популяції низька концентрація вітаміну D була пов'язана з ожирінням, незалежну роль вітаміну D при наявності СПКЯ оцінити складно [11].…”

Section: клінічна ендокринологіяunclassified

“…Отримані результати свідчать про існування взаємозв'язку між вітаміном D і ІМТ у жінок зі СПКЯ та узгоджуються з іншими дослідженнями [11]. Відомо, що ожиріння може сприяти зниженню рівня циркулюючого вітаміну D, затримуючи вітамін D в жирових тканинах.…”

Section: результати та їх обговоренняunclassified

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Arkhypkina¹,

Lyubimovа²,

Bondarenko³

et al. 2020

PEP

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The aim of the work was to study the relationship between levels of vitamin D, obesity and lipid profilein patients with polycystic ovary syndrome (PCOS).Materials and methods. The study involved 120 women: 60 patients with PCOS and 60 healthy women.All examined were divided into groups depending on body mass index (BMI): patients with PCOS — 30 withBMI ≤ 25 kg/m2and 30 with BMI ≥ 25 kg/m2; healthy women — 30 with BMI ≤ 25 kg/m2and 30 withBMI ≥ 25 kg/m2. Results. Patients with a BMI of ≥ 25 kg/m2had a lower average level of vitamin D (P < 0,001) than patientswith a BMI of ≤ 25 kg/m2; among of them there was a higher percentage of women with a pronounceddeficiency (23.3% versus 13.3%) and deficiency (60% versus 50%) of vitamin D; nobody had not adequate levelsof vitamin D. It was established a negative correlation between the level of vitamin D and BMI (r = – 0.275;P < 0.05), waist circumference (r = – 0.604; P < 0.001), the coefficient of waist circumference/ hips circumference(r = – 0.512; P < 0.001). Abdominal type of adipose tissue distribution, which was observed among patients withboth overweight and normal weight, may be one of the factors contributing to dysregulation of metabolism of vitaminD in conditions of PCOS.Women with PCOS had lipid metabolism disorders with increased atherogenic and decreased levels of antiatherogeniclipid fractions wich was intensif with increasing body weight. It was established a negative correlationbetween the level of vitamin D and triglycerides (r = – 0.437; P < 0.001), and positive association with highdensity lipoprotein cholesterol (r = 0.492; P < 0.001).In healthy women, only a negative correlation between the concentration of vitamin D and BMI (r = – 0.562;P < 0.001) was establish and there was no association with other anthropometric indicators and indicators of theblood lipid spectrum.Conclusion. Patients with PCOS have a higher prevalence and severity of deficiency of vitamin D.Disruption of regulation of vitamin D metabolism may be a consequence of existing obesity, and a decrease invitamin D levels is an additional factor that increase the dyslipidemia that exists in PCOS.

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