Is there a relationship between bone and critical illness?

Zhang, Yaozong; Du, Xiaolan; Chen, Lin

doi:10.1016/j.mehy.2010.11.035

Cited by 1 publication

(1 citation statement)

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“…However, as one of the largest organs with an emerging important role in regulating multiple organs/systems, changes of the skeleton and its functional role during critical illness remain poorly understood. We previously proposed a relationship between bone and critical illness and the potential important role of bone dysfunction in critical illness 85, which has been supported by increasing evidences.…”

Section: Extraskeletal Functions Of Bone Mediated By Bdfsmentioning

confidence: 75%

Bone function, dysfunction and its role in diseases including critical illness

Su¹,

Yang²,

Xie³

et al. 2019

Int. J. Biol. Sci.

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The skeleton is one of the largest organs in the human body. In addition to its conventional functions such as support, movement and protection, the skeleton also contributes to whole body homeostasis and maintenance of multiple important non-bone organs/systems (extraskeletal functions). Both conventional and extraskeletal functions of the skeleton are defined as bone function. Bone-derived factors (BDFs) are key players regulating bone function. In some pathophysiological situations, including diseases affecting bone and/or other organs/systems, the disorders of bone itself and the subsequently impaired functions of extraskeletal organs/systems caused by abnormal bone (impaired extraskeletal functions of bone) are defined as bone dysfunction. In critical illness, which is a health status characterized by the dysfunction or severe damage of one or multiple important organs or systems, the skeleton shows rapid bone loss resulting from bone hyper-resorption and impaired osteoblast function. In addition, the dysfunctions of the skeleton itself are also closely related to the severity and prognosis of critical illness. Therefore, we propose that there is bone dysfunction in critical illness. Some methods to inhibit osteoclast activity or promote osteoblast function by the treatment of bisphosphonates or PTH1-34 benefit the outcome of critical illness, which indicates that enhancing bone function may be a potential novel strategy to improve prognosis of diseases including critical illness.

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Section: Extraskeletal Functions Of Bone Mediated By Bdfsmentioning

confidence: 75%