Is There a Relationship Between Autoantibodies and Silicone-Gel Implants?

Peters, Walter; Keystone, Edward; Snow, K. M.; Rubin, Laurence A.; Smith, Dennis C.

doi:10.1097/00000637-199401000-00001

Cited by 49 publications

(15 citation statements)

References 0 publications

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“…When silicone lymphadenopathy is caused by gel or liquid, some foreign body giant cells may be seen. This difference is as yet unexplained [8,15,17].…”

Section: Discussionmentioning

confidence: 93%

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Silicone granulomas: 30 years after injection of fluid silicone for breast and inner thigh augmentation – a possible case of human adjuvant disease improved after massive siliconomas removal

et al. 1998

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“…When silicone lymphadenopathy is caused by gel or liquid, some foreign body giant cells may be seen. This difference is as yet unexplained [8,15,17].…”

Section: Discussionmentioning

confidence: 93%

“…(3)Foreign body granulomas can be observed histopathologically in an injected area and in the draining lymph nodes. (4) The presence of serologic abnormalities such as autoantibodies [15,17]. (5) The symptoms improved after the removal of the foreign material [10].…”

Section: Discussionmentioning

confidence: 99%

Silicone granulomas: 30 years after injection of fluid silicone for breast and inner thigh augmentation – a possible case of human adjuvant disease improved after massive siliconomas removal

et al. 1998

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“…A higher incidence of certain ANA patterns, e.g. anticentromere antibodies, which are associated with scleroderma-related disorders, has been reported in women with silicone breast implants [38]. In patients with the fibromyalgia-related chronic fatigue syndrome, ANA directed to nuclear envelope proteins have been found [40].…”

Section: Discussionmentioning

confidence: 99%

“…ANA reactivity in women with silicone breast implants has been the topic of several studies [9,36,37]. The prevalence of ANA in women with silicone breast implants was reported to be the same as that of control subjects in one study [38], whereas other, uncontrolled studies found ANA in more than half of women with silicone breast implants referred for evaluation of rheumatic complaints [36,39]. However, most studies have addressed small, highly selected groups of patients.…”

Section: Discussionmentioning

confidence: 99%

Rheumatic Manifestations in Danish Women with Silicone Breast Implants

et al. 2001

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The aim of this study was to investigate whether women with silicone breast implants (SBI) present with a unique rheumatic symptomatology. We assessed the profile of rheumatic disease in six groups of women identified through Danish hospital and population registers, three groups of women with a prior hospital diagnosis of muscular rheumatism (a non-specific diagnostic code) who had previously undergone SBI surgery (n = 28), breast reduction surgery (n = 29) or no breast surgery (n = 27); and three groups of women without a diagnosis of muscular rheumatism who had undergone SBI surgery (n = 21), breast reduction surgery (n = 27) or no breast sugery (n = 56). All women in the study population (n = 188) underwent a thorough clinical examination, blood tests and a personal interview. In all study groups soft-tissue rheumatism and degenerative diseases were the most frequent diagnoses. Women with a prior diagnosis of muscular rheumatism but no prior breast surgery had a significantly higher prevalence of soft-tissue rheumatism than those with breast implant or reduction surgery. No significant differences in the frequencies of rheumatic diseases were observed among the three groups of women without previous muscular rheumatism. No specific pattern of inflammatory rheumatic disorders or soft-tissue complaints was identified among the women with SBI, and blood tests for autoimmunity revealed no unique pattern. Overall, women with earlier rheumatism had significantly increased frequencies of rheumatic conditions than did those without. We found no evidence of a rheumatic symptomatology unique to women with silicone breast implants. Our study emphasises the need for consideration of prior rheumatic disease when evaluating rheumatic manifestations in women with SBI.

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“…[45][46][47][48] However, these isolated case reports, which increased in freautoantibodies. 38 However, other investigators found that antibodies to silicone surface-associated antigens quency since the publicity in 1991, have not been viewed in the context of epidemiologic studies and fail are elevated in symptomatic patients with breast implants and that the antibodies are associated with to take a placebo effect into account. It was not until 1992 that case -control studies evaluating the associasymptoms.…”

Section: Silicone and Connective Tissue Diseasesmentioning

confidence: 99%