Is there a relationship between cord blood pregnancy-associated plasma protein-A and birth weight and length?

Senses, Dursun Alí; Coşkun, Abdurrahman; Kiseli, Mine; Berberoglu, Murat; Kandemir, Ömer; Yalvaç, Serdar; Duran, Sadik

doi:10.1016/j.earlhumdev.2006.10.005

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…Yenidoğan boyu ile PAPP-A MoM değerleri arasındaki ilişki literatürde çelişkilidir. İlk trimester PAPP-A MoM değerleri ile yenidoğan boyu arasında pozitif korelasyon olduğunu öne süren çalışmalar olduğu gibi (29) doğumda bakılan kordon kanında PAPP-A düzeyleri ile negatif korelasyon olduğunu (32) ya da herhangi bir ilişkinin olmadığını (31) ileri süren çalışmalar mevcuttur. Bizim çalışmamızda yenidoğan boyu ile PAPP-A MoM değeri arasında pozitif yönde zayıf korelasyon (r:0.166, p:<0.001) gözlenmiştir.…”

Section: Discussionunclassified

Komplikasyonsuz Gebeliklerde Pregnancy Associated Plasma Protein-A ve Serbest Human Koryonik Gonadotropin Değerlerinin Bebeğin Cinsiyeti, Kilosu ve Boyunu Belirlemedeki Yeri

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2021

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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Amaç: Maternal serumda 0.5-2.5 MoM aralığındaki sß-HCG ve PAPP-A MoM değerlerinin fetal cinsiyet, yenidoğan ağırlığı ve boyunu tahmin etmede etkinliğini değerlendirmek. Gereç ve Yöntemler: Birinci trimester taraması için anomali taraması yapılan 519 tekil, komplikasyonsuz gebelikte ölçülen tarama testi biyokimyasal bileşenlerinden sß-HCG ve PAPP-A değerleri ile doğum sonu yenidoğanın cinsiyet, boy ve ağırlık verileri retrospektif olarak bulunarak karşılaştırıldı. Bulgular: sß-HCG MoM değerinin, yenidoğan cinsiyeti ile ilişkili olduğu (U: 29240.5, p: 0.01) ve kız cinsiyete sahip fetüslerde daha yüksek olduğu bulundu. ROC analizinde sß-HCG MoM değerinin kız cinsiyeti tanımada istatistiksel olarak anlamlı (AUC: %56.6, güven aralığı: 0.516-0.615, p: 0.01) olduğu tespit edildi. sß-HCG MoM değerinin, yenidoğan cinsiyetini doğru tahmin etmedeki sensitivitesinin %66.3, spesifitesinin ise %51.9 olduğu (cut off değeri: 0.855 MoM) görüldü. PAPP-A MoM değerinin yeni doğan ağırlığı (r: 0.175, p: <0.001) ve boyu (r: 0.166, p: <0.001) ile pozitif bir korelasyon gösterdiği ve sß-HCG MoM değeri ile yenidoğan boyu arasında çok zayıf bir korelasyon olduğu (r: 0.099, p: <0.005) izlendi. Sonuç: Çalışmamız birinci trimester tarama testi biyokimyasal belirteçlerinden sß-HCG MoM değerinin fetal cinsiyet ile ilişkili olduğunu göstermiştir. Bu ilişki günümüzde fetal cinsiyeti %100 doğruluk ile tahmin edebilen yöntemler mevcut olduğundan klinik anlamda kullanabilmek için yeterli değildir ancak yine de genetik geçişli bazı hastalıkların değerlendirilmesinde fetal cinsiyet için fikir verebilir. Ayrıca çalışmamızda komplikasyonsuz gebelerde PAPP-A MoM seviyesinin, yenidoğanın boyu ve ağırlığı gibi fetal gelişimi gösteren parametreler ile ilgili bilgi verdiği görülmüştür. Bu ilişkinin fetal gelişimi etkileyen birçok sosyo-demografik etkenin hesaba katıldığı geniş kapsamlı prospektif çalışmalar yapılarak daha da netleşeceği kanaatindeyiz.

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Section: Discussionunclassified

Komplikasyonsuz Gebeliklerde Pregnancy Associated Plasma Protein-A ve Serbest Human Koryonik Gonadotropin Değerlerinin Bebeğin Cinsiyeti, Kilosu ve Boyunu Belirlemedeki Yeri

Baylan

Karaküçük

2021

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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“…In some studies, a positive correlation was found; however, other investigators have observed no association between maternal protein A and birth weight [10, 12, 20, 21, 30, 31]. Most surprisingly, Senses et al [4] found a significant negative correlation between PAPP-A levels and birth weight, but the authors measured this protein level only in cord blood and speculated that this protein affected the length of newborns more strongly than weight. Generally, birth weight prediction has been tested by a combination of PAPP-A, free β-human chorionic gonadotrophin (β-hCG) and nuchal translucency (NT) in the first trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Serum pregnancy-associated plasma protein A levels in the first, second and third trimester of pregnancy: relation to newborn anthropometric parameters and maternal tobacco smoking

Chełchowska¹,

Gajewska²,

Mazur³

et al. 2016

aoms

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IntroductionThe purpose of this study was to evaluate the associations of the first, second and third trimester serum pregnancy-associated plasma protein A (PAPP-A) concentrations with neonatal anthropometric parameters. The effect of tobacco smoking during pregnancy on PAPP-A level was also studied.Material and methodsOne hundred and fifty healthy pregnant women were divided into smoking and tobacco-abstinent groups. Serum PAPP-A level was measured with the KRYPTOR rapid random-access immunoassay analyzer. The relationship between PAPP-A and newborn related outcome as well as markers of estimated intensity of cigarette smoking was evaluated by univariate and multivariate linear regression.ResultsPregnancy-associated plasma protein A concentration was positively correlated with birth weight in the first (β = 31.6; p < 0.001), second (β = 10.6; p < 0.05), and third (β = 4.6; p < 0.001) trimester of gestation. A significant association between PAPP-A and birth body length and head circumference in the second (β = 0.02; p < 0.05) and third trimester (β = 0.01; p < 0.01) was also found. The serum PAPP-A levels were significantly lower in the smoking than in the tobacco-abstinent group in each trimester of pregnancy (p < 0.001). The largest impact of the number of cigarettes smoked per day on PAPP-A level was found in the second (β = –1.2; p = 0.004) and third trimester (β = –2.6; p = 0.001).ConclusionsMaternal serum PAPP-A levels during gestation might be significant predictors for birth weight. Increased PAPP-A concentrations in the second and third trimester appeared to also be predictive for newborn body length and head circumference. Smoking alters maternal PAPP-A levels in all trimesters, with the greatest impact related to the number of cigarettes smoked per day.

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“…For example, Suski et al studied the difference in plasma proteome between preterm newborns stratified by their gestational age and found significant differences in proteins belonging to the inflammatory, immunomodulatory, and coagulation domains. In addition, various cord blood proteins have been reported as associated with birth weight in single-protein studies . Nevertheless, the long-term outcomes associated with the cord blood proteome remain understudied.…”

Section: Introductionmentioning

confidence: 99%

Cord Blood Proteomic Profiles, Birth Weight, and Early Life Growth Trajectories

Van Pee,

Martens,

Alfano

et al. 2024

JAMA Netw Open

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ImportanceThe cord blood proteome, a repository of proteins derived from both mother and fetus, might offer valuable insights into the physiological and pathological state of the fetus. However, its association with birth weight and growth trajectories early in life remains unexplored.ObjectiveTo identify cord blood proteins associated with birth weight and the birth weight ratio (BWR) and to evaluate the associations of these cord blood proteins with early growth trajectories.Design, Setting, and ParticipantsThis cohort study included 288 mother-child pairs from the ongoing prospective Environmental Influence on Early Aging birth cohort study. Newborns were recruited from East-Limburg Hospital in Genk, Belgium, between February 2010 and November 2017 and followed up until ages 4 to 6 years. Data were analyzed from February 2022 to September 2023.Main Outcomes and MeasuresThe outcome of interest was the associations of 368 inflammatory-related cord blood proteins with birth weight or BWR and with early life growth trajectories (ie, rapid growth at age 12 months and weight, body mass index [BMI] z score, waist circumference, and overweight at age 4-6 years) using multiple linear regression models. The BWR was calculated by dividing the birth weight by the median birth weight of the population-specific reference growth curve, considering parity, sex, and gestational age. Results are presented as estimates or odds ratios (ORs) for each doubling in proteins.ResultsThe sample included 288 infants (125 [43.4%] male; mean [SD] gestation age, 277.2 [11.6] days). The mean (SD) age of the child at the follow-up examination was 4.6 (0.4) years old. After multiple testing correction, there were significant associations of birth weight and BWR with 7 proteins: 2 positive associations: afamin (birth weight: coefficient, 341.16 [95% CI, 192.76 to 489.50]) and secreted frizzled-related protein 4 (SFRP4; birth weight: coefficient, 242.60 [95% CI, 142.77 to 342.43]; BWR: coefficient, 0.07 [95% CI, 0.04 to 0.10]) and 5 negative associations: cadherin EGF LAG 7-pass G-type receptor 2 (CELSR2; birth weight: coefficient, −237.52 [95% CI, −343.15 to −131.89]), ephrin type-A receptor 4 (EPHA4; birth weight: coefficient, −342.78 [95% CI, −463.10 to −222.47]; BWR: coefficient, −0.11 [95% CI, −0.14 to −0.07]), SLIT and NTRK-like protein 1 (SLITRK1; birth weight: coefficient, −366.32 [95% CI, −476.66 to −255.97]; BWR: coefficient, −0.11 [95% CI, −0.15 to −0.08]), transcobalamin-1 (TCN1; birth weight: coefficient, −208.75 [95% CI, −305.23 to −112.26]), and unc-5 netrin receptor D (UNC5D; birth weight: coefficient, −209.27 [95% CI, −295.14 to −123.40]; BWR: coefficient, −0.07 [95% CI, −0.09 to −0.04]). Further evaluation showed that 2 proteins were still associated with rapid growth at age 12 months (afamin: OR, 0.32 [95% CI, 0.11-0.88]; TCN1: OR, 2.44 [95% CI, 1.26-4.80]). At age 4 to 6 years, CELSR2, EPHA4, SLITRK1, and UNC5D were negatively associated with weight (coefficients, −1.33 to −0.68 kg) and body mass index z score (coefficients, −0.41 to −0.23), and EPHA4, SLITRK1, and UNC5D were negatively associated with waist circumference (coefficients, −1.98 to −0.87 cm). At ages 4 to 6 years, afamin (OR, 0.19 [95% CI, 0.05-0.70]) and SLITRK1 (OR, 0.32 [95% CI, 0.10-0.99]) were associated with lower odds for overweight.Conclusions and RelevanceThis cohort study found 7 cord blood proteins associated with birth weight and growth trajectories early in life. Overall, these findings suggest that stressors that could affect the cord blood proteome during pregnancy might have long-lasting associations with weight and body anthropometrics.

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Is there a relationship between cord blood pregnancy-associated plasma protein-A and birth weight and length?

Cited by 8 publications

References 23 publications

Komplikasyonsuz Gebeliklerde Pregnancy Associated Plasma Protein-A ve Serbest Human Koryonik Gonadotropin Değerlerinin Bebeğin Cinsiyeti, Kilosu ve Boyunu Belirlemedeki Yeri

Komplikasyonsuz Gebeliklerde Pregnancy Associated Plasma Protein-A ve Serbest Human Koryonik Gonadotropin Değerlerinin Bebeğin Cinsiyeti, Kilosu ve Boyunu Belirlemedeki Yeri

Serum pregnancy-associated plasma protein A levels in the first, second and third trimester of pregnancy: relation to newborn anthropometric parameters and maternal tobacco smoking

Cord Blood Proteomic Profiles, Birth Weight, and Early Life Growth Trajectories

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