Is there a relationship between cardiovascular risk factors and dehydroepiandrosterone sulfate levels in childhood obesity?

Akyürek, Nesibe; Atabek, Mehmet Emre; Eklioğlu, Beray Selver; Alp, Hayrullah

doi:10.1515/jpem-2014-0253

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…However, CIMT was correlated with DHEA-SO 4 levels. In a study investigating the relationship between cardiovascular risk factors and DHEA-SO 4 levels in obese children, the DHEA-SO 4 level was found to be positively correlated with WC, waist/hip ratio, and CIMT [41] .…”

Section: Discussionmentioning

confidence: 99%

The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

Çelik

Alp²,

Çamtosun³

et al. 2016

Horm Res Paediatr

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Aim: The aim of this study was to investigate the cardiovascular risk of children with premature adrenarche (PA). Methods: A total of 75 children (44 with PA and 31 control subjects) aged 6-10 years were included in the study. Their metabolic, anthropometric, and echocardiographic parameters were recorded and compared. Results: Triglyceride, DHEA-SO₄, and 17-hydroxyprogesterone levels were significantly higher in the PA group (p = 0.04, p = 0.002, and p = 0.01, respectively). The echocardiographic assessments revealed that the left ventricular end-diastolic diameter (LVEDD) (p < 0.001), left ventricle (LV) and right ventricle (RV) ejection times (p = 0.031 and p = 0.035, respectively), and LV and RV Tei index measurements (p = 0.033 and p = 0.006, respectively) were significantly higher in the PA group than in the control group, whereas the E/e' ratio of the mitral lateral annulus was significantly lower in the PA group (p = 0.006). Additionally, carotid intima-media thickness and epicardial adipose tissue measurements were significantly increased in the PA group compared to the control group (p < 0.001). Conclusion: Early atherosclerotic changes and subclinical impairment of cardiac function were observed in children with PA. It is possible that these children are on a course for early cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

Çelik

Alp²,

Çamtosun³

et al. 2016

Horm Res Paediatr

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“…In this investigation, lipids and lipid-like metabolites, such as DHEAS, adrenosterone, 2-hydroxyisocaproic acid, 4-acetamidobutanoate and gamma-muricholic acid, showed significant changes in the four groups of hypertensive children and were associated with the emergence of childhood hypertension. Circulating DHEAS is a form of dehydroepiandrosterone [ 25 ], which is mainly produced in the adrenal gland and reaches a maximum plasma level between 15 and 25 years of age. In human blood, it is the steroid hormone that is most prevalent.…”

Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomics Analysis Using UHPLC-Q-TOF/MS Reveals Metabolic Changes Associated with Hypertension in Children

Zhang

Liu

et al. 2023

Nutrients

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The mechanism of hypertension in children remains elusive. The objective of this study was to analyze plasma metabolomics characteristics to explore the potential mechanism of hypertension in children. Serum samples from 29 control children, 38 children with normal body mass index and simple hypertension (NBp), 8 children overweight with simple hypertension (OBp), 37 children with normal body mass index and H-type hypertension (NH) and 19 children overweight with H-type hypertension (OH) were analyzed by non-targeted metabolomics. A total of 1235 differential metabolites were identified between children with hypertension and normal controls, of which 193 metabolites including various lipids were significantly expressed. Compared with the control group, 3-dehydroepiandrosterone sulfate, oleic acid and linoleic acid were up-regulated, and gamma-muricholic acid was down-regulated in the NBp group; 3-dehydroepiandrosterone sulfate, 4-acetamidobutanoate and 1-hexadecanoyl-2-octadecadienoyl-sn-glyero-3-phosphocholine were up-regulated in the OBp group, whereas adenosine and 1-myristoyl-sn-glyero-3-phosphocholine were down-regulated; in the NH group, 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine, phenol and 3-methoxytyramine were up-regulated, while pentadecanoic acid was down-regulated; in the OH group, NG,NG-dimethyl-L-arginine, 1-palmitoyl-sn-glycero-3-phosphocholine and monoethyl phthalate were up-regulated, while phloretin and glycine were down-regulated. The results showed that the children with hypertension had obvious disorders of lipid metabolism (especially in the overweight hypertension group), which led to the occurrence of hypertension. Additionally, the concentration of NO production-related NG, NG-dimethyl-L-arginine, was significantly increased, which may play an important role in H-type hypertension in children.

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“…In this issue of our journal we have compiled comprehensive data on several aspects of childhood obesity to highlight the importance of obesity research for society, individuals at risk and the affected patients (2,4,5,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). It is clear that we have to strengthen our efforts in respect to investigate prevention and interventions that will work both on an individual and a societal level.…”

Section: Discussionmentioning

confidence: 99%

“…In this issue of JPEM a relationship between dehydroepiandrosterone is proven (17), the variability of blood pressure in relation to body fat mass and ethnicity is shown (18) and an association between cardiovascular risk and carotid intima-media thickness is suggested (19).…”

Section: Cardiovascular Riskmentioning

confidence: 94%

Childhood obesity at the crossroads

Kieß¹,

Penke²,

Sergeyev³

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Is there a relationship between cardiovascular risk factors and dehydroepiandrosterone sulfate levels in childhood obesity?

Cited by 7 publications

References 12 publications

The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

Untargeted Metabolomics Analysis Using UHPLC-Q-TOF/MS Reveals Metabolic Changes Associated with Hypertension in Children

Childhood obesity at the crossroads

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