Is there a relationship between systemic perfusion temperature during coronary artery bypass grafting and extent of intraoperative ischemic central nervous system injury?

Engelman, Richard M.; Pleet, A. Bernard; Hicks, Richard J.; Rousou, John A.; Flack, Joseph E.; Deaton, David W.; Pekow, Penelope S.; Gregory, Cheryl A.

doi:10.1016/s0022-5223(00)70177-2

Cited by 20 publications

(10 citation statements)

References 8 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, controversial results have been reported regarding the use of hypothermic strategies for myocardial (11,(38)(39)(40)(41)(42)(43)(44) and cerebral protection (38,40,(45)(46)(47)(48)(49) during adult cardiac surgery. Up to now, no study provided conclusive results on the beneficial or harmful effects of mild/moderate hypothermia during CPB.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary artery blood temperature at admission to the intensive care unit is predictive of outcome after on‐pump coronary artery bypass surgery

Lahtinen

Biancari

Ala‐Kokko

et al. 2004

Scandinavian Cardiovascular Journal

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Pulmonary artery blood temperature at admission to the intensive care unit is predictive of outcome after on‐pump coronary artery bypass surgery

Lahtinen

Biancari

Ala‐Kokko

et al. 2004

Scandinavian Cardiovascular Journal

View full text Add to dashboard Cite

show abstract

“…Absence or reduction in cerebral blood flow decreases oxygen and glucose supply and impairs neuronal metabolism. 47,48 Between the onset of ischemia and neuronal death appreciate the following metabolic steps occur ( Fig. 1): [73][74][75] 1.…”

Section: Neurochemistry Of Cerebral Ischemiamentioning

confidence: 99%

“…Certain maneuvers can distort their measurement; for instance, high levels of S100␤ are present in the blood drained from the mediastinum by cardiotomy suction reflecting the presence of the protein in mediastinal fat cells. 81 Factors such as hemodilution, hemolysis, extracerebral liberation, cardiotomy suction use, 48 auto transfusion or renal failure may be confounding factors regarding biochemical evaluation of neuronal damage. 7,24,88 Recently, Siman et al 100 evaluated variations in 5 potential CSF markers for neurologic damage in patients undergoing aortic aneurism repair with or without DHCA.…”

Section: Neuronal Specific Enolase (Nse): Nse Is Involved In Glycolysismentioning

confidence: 99%

Neurological Damage Related to Cardiac Surgery

Carrascal¹,

Peral²

2010

The Neurologist

View full text Add to dashboard Cite

Even in milder cases, neurologic complications related to cardiac surgery increase mortality, hospitalization time, and rehabilitation costs, and so contribute to the decrease in quality of life. The incidence of neurologic complications has remained unchanged during the last years, despite age and comorbidity increasing. Improvement in technical approaches has probably contributed to maintain these percentages. Although most of the complications may be related to cardiopulmonary bypass, others factors are also involved. Identifying high risk patients could reduce incidence of complications within high risk groups, but this is probably an insufficient preventive strategy. In a population progressively older and presumably affected by an increasing number of diseases, preventive strategies should be focused on 3 aspects: first, technical improvements in cardiac surgery and cerebral protection; second, pharmacologic therapy; and, finally, identification of reliable techniques to evaluate neuropsychological dysfunction after cardiac surgery. Future efforts will be necessary to identify surrogate markers of neurologic damage and its functional outcome, perhaps related to genetic susceptibility.Only with all of these instruments, really effective preventive or palliative strategies could be planned and applied.

show abstract

“…Indeed, the definition of warm CPB is quite different in different studies, ranging from 33 to 37 °C. More recently, the use of what is called ‘tepid’ bypass temperatures (31–34 °C) has appeared in the literature [1, 9, 10]. Only studies of patients undergoing coronary artery bypass grafting are listed in Table 3.…”

Section: Effects Of Cardiopulmonary Bypass Temperature On Neurologicamentioning

confidence: 99%

Cardiopulmonary bypass temperature and brain function

2005

View full text Add to dashboard Cite

A debate has emerged in recently published studies about the optimum cardiopulmonary bypass temperature for good neurological outcome - warm vs. cold, i.e. normothermic vs. hypothermic. Although many comparative studies have been performed, the results of these studies are inconclusive and are difficult to interpret. Brain function has been studied in terms of neurological and neuropsychological outcome, protein S100beta levels as a marker of brain damage, and cerebral oxygenation using jugular bulb oximetry and near-infrared spectroscopy. The studies produce no conclusive proof of the superiority of warm or cold cardiopulmonary bypass. However, it appears that any degree of bypass hypothermia (< 35 degrees C) may protect the brain. On the other hand, even a slight increase in bypass temperature to > 37 degrees C may cause marked brain injury.

show abstract

Is there a relationship between systemic perfusion temperature during coronary artery bypass grafting and extent of intraoperative ischemic central nervous system injury?

Abstract: In this series of 291 patients randomized to perfusion temperature, we observed no relationship between the size of a cerebral ischemic infarct and the perfusate temperature during coronary revascularization.

Cited by 20 publications

References 8 publications

Pulmonary artery blood temperature at admission to the intensive care unit is predictive of outcome after on‐pump coronary artery bypass surgery

Pulmonary artery blood temperature at admission to the intensive care unit is predictive of outcome after on‐pump coronary artery bypass surgery

Neurological Damage Related to Cardiac Surgery

Cardiopulmonary bypass temperature and brain function

Contact Info

Product

Resources

About