Is there a relationship between restless legs syndrome and medical problems in pregnant women? A cross-sectional study in Iran

Abedi, Parvin; Bagheri, Roghieh; Qorbani, Mostafa; Ansari, Somayeh

doi:10.1007/s13760-018-01062-7

Cited by 5 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RLS prevalence during pregnancy in different countries has been reported at a range of 13.5-34%, in line with our findings [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. According to Turkish studies, the prevalence of RLS during pregnancy ranges from 15.4% to 61.2% [5][6][7][8][9]11,12].…”

Section: Discussionsupporting

confidence: 90%

“…RLS during pregnancy is linked to gestational hypertension, preeclampsia, poor sleep and quality of life, daytime lethargy, and depression. History of RLS before conception, RLS during a previous pregnancy, coffee consumption before conception, peptic ulcer disease, hemoglobin < 11 g/dL, and inadequate supplementation of iron and folate during pregnancy, especially when iron deficiency is present, have been identified as risk factors for the development of RLS during pregnancy [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy

Turan,

Aşkın Turan,

Butun

et al. 2023

Cureus

View full text Add to dashboard Cite

Objectives: The current study aimed to search the prevalence and severity of restless legs syndrome (RLS) in pregnancy according to the three trimesters and predictive factors of RLS in pregnancy based on validated diagnostic tools and a thorough literature review.Methods: The cross-sectional descriptive study included 500 pregnant women without comorbidities who were interviewed face-to-face. Age, height, weight, week of pregnancy, smoking, alcohol, caffeine use, regular exercise, and lab test results from the last visit were all included in the data. Only women satisfying the RLS diagnostic criteria were given the Restless Legs Syndrome Rating Scale.Results: The prevalence of RLS was found to be 29.2% with the highest rate in the third trimester (64.4%). In all trimesters, low ferritin (first trimester: p = 0.004; second trimester: p < 0.001; third trimester: p < 0.001), folic acid (first trimester: p = 0.001; second trimester: p < 0.001; third trimester: p < 0.001), vitamin B12 (first trimester: p = 0.003; second trimester: p < 0.001; third trimester: p < 0.001), and hemoglobin (first trimester: p < 0.001; second trimester: p < 0.001; third trimester: p < 0.001) levels were associated with RLS. In the second and third trimesters, low magnesium (p < 0.001 and p < 0.001, respectively) and high creatinine (p = 0.027 and p < 0.001, respectively) levels were associated with RLS. Higher thyroid-stimulating hormone and free T4 levels were associated with RLS in the third trimester but not in the first and second trimesters (median: 2.4 vs.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy

Turan,

Aşkın Turan,

Butun

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…A single study was included from Nigeria (35), Thailand (36), Peru (37), and Brazil (38) each. Two studies were from India (39,40), three were from Pakistan (41)(42)(43), four from Iran (17, [44][45][46], four from China (7,8,47,48), and five from Turkey (49)(50)(51)(52)(53). According to WHO region classification studies included for this review, one was from the African region (35), three from the south-east region (36, 39, 40), five from the European region (49-53), four from the western pacific region (7,8,47,48), two from the American region (37,38), and eight from the Eastern Mediterranean (EM) region (17, [41][42][43][44][45][46].…”

Section: Results Characteristics Of Included Studiesmentioning

confidence: 99%

“…Two studies were from India (39,40), three were from Pakistan (41)(42)(43), four from Iran (17, [44][45][46], four from China (7,8,47,48), and five from Turkey (49)(50)(51)(52)(53). According to WHO region classification studies included for this review, one was from the African region (35), three from the south-east region (36, 39, 40), five from the European region (49-53), four from the western pacific region (7,8,47,48), two from the American region (37,38), and eight from the Eastern Mediterranean (EM) region (17, [41][42][43][44][45][46]. The World Bank's classification for lower-and uppermiddle-income countries, which was based on the gross national income per capita of the countries (from $1,136 to 4,465, and $4,466 to 13,845, respectively), was utilized (54, 55).…”

Section: Results Characteristics Of Included Studiesmentioning

confidence: 99%

“…This could result in a higher likelihood of diagnosis among affluent women compared to those with comparatively limited access to healthcare, higher stress levels associated with certain lifestyles or occupations, and sedentary lifestyles. Additionally, advanced gestational age among thirdtrimester pregnant women might have contributed to higher RLS prevalence (45).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and factors associated with restless legs syndrome among pregnant women in middle-income countries: a systematic review and meta-analysis

Mislu,

Assalfew,

Arage

et al. 2023

Front. Med.

View full text Add to dashboard Cite

IntroductionRestless legs syndrome (RLS) is a debilitating condition characterized by uncomfortable sensations in the legs, typically occurring during periods of rest or sleep. It is more prevalent during pregnancy and is linked to sleep disturbances, diminished quality of life, and pregnancy complications. However, previous studies yielded inconsistent findings among pregnant women in middle-income countries. Consequently, this systematic review and meta-analysis sought to determine the pooled prevalence of restless legs syndrome and its associated factors in these populations.MethodA systematic review and meta-analysis was conducted on published studies from middle-income countries until May 2023. The review strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant search terms were used to search for studies in PubMed, MEDLINE, EMBASE, and Google Scholar. Data extraction was performed using the Joanna Briggs Institute tool for prevalence studies. The meta-analysis was conducted using STATA 17 software, and heterogeneity was assessed using the I2 test, while publication bias was evaluated using Egger's test. Forest plots were also used to present the pooled prevalence and odds ratio (OR) with a 95% confidence interval (CI) using the random-effects model.ResultThis review included 22 studies from nine countries with a total of 17, 580 study participants. The overall pooled prevalence of RLS among pregnant women in middle-income countries was 13.82% (95% CI: 13.31, 14.32), and having low hemoglobin level (AOR: 1.68, 95% CI: 1.29, 2.18), history of RLS (AOR: 7.54, 95% CI: 3.02, 18.79), muscle cramps (AOR: 3.58, 95% CI: 1.21, 10.61), excessive day time sleepiness (AOR: 4.02, 95% CI: 1.34, 12.04), preeclampsia (AOR: 2.06, 95% CI: 1.28, 3.30), and taking prophylactic iron supplementation (AOR: 0.59, 95% CI: 0.50, 0.69) were the identified factors associated with it.ConclusionGenerally, nearly one in every eight pregnant women in middle-income countries develop restless legs syndrome during pregnancy. Having low hemoglobin level, a history of RLS, muscle cramps, excessive daytime sleepiness, preeclampsia, and taking prophylactic iron supplementation were the identified factors associated with it. These findings underscore the importance of addressing the identified factors associated with RLS in order to effectively mitigate its occurrence among pregnant women.

show abstract

Sleep disturbances during pregnancy and adverse maternal and fetal outcomes: A systematic review and meta-analysis

Zhang

Wang

et al. 2021

Sleep Medicine Reviews

111

View full text Add to dashboard Cite

Is there a relationship between restless legs syndrome and medical problems in pregnant women? A cross-sectional study in Iran

Cited by 5 publications

References 21 publications

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy

The Prevalence, Severity, and Predictive Factors of Restless Legs Syndrome in Pregnancy

Prevalence and factors associated with restless legs syndrome among pregnant women in middle-income countries: a systematic review and meta-analysis

Sleep disturbances during pregnancy and adverse maternal and fetal outcomes: A systematic review and meta-analysis

Contact Info

Product

Resources

About