Is There a Rationale behind Pharmacotherapy in Idiopathic Gynecomastia?

Kasielska‐Trojan, Anna; Danilewicz, Marian; Antoszewski, Bogusław

doi:10.1159/000487753

Cited by 2 publications

(1 citation statement)

References 23 publications

(25 reference statements)

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“…Larger patient populations may enable identification of any plausible link between the degree of immunoexpression of these parameters and the severity of gynecomastia. The findings of our study are concurrent with the study by Kasielska‐Trojan A et al, in terms of a local paracrine expression of an estrogenic milieu, despite normal circulating oestrogens, in patients with idiopathic gynecomastia (Kasielska‐Trojan et al, 2018). The clinical implications of the study concur with available literature evidence asserting the superior efficacy of selective oestrogen receptor modulators over aromatase inhibitors in patients with idiopathic gynecomastia (Mannu et al, 2018; Narula & Carlson, 2014).…”

Section: Discussionsupporting

confidence: 92%

The role of steroid receptors, peptides and growth factors in the aetiopathogenesis of idiopathic gynecomastia

et al. 2022

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Idiopathic gynecomastia is a diagnosis of exclusion. We aimed to evaluate the role of steroids, peptides and growth factors in these patients. Those with bilateral idiopathic gynecomastia (n = 29) (Simon's grade IIb or III) who underwent gland excision were evaluated by immunohistochemical techniques using semi‐quantitative grading for oestrogen receptor (ER), progesterone receptor (PR), aromatase, androgen receptor (AR), peptides (IGF‐1, IGF‐2, HER‐2, parathyroid‐hormone related peptide [PTHrP]) and growth factors (EGFR, TGFβ). The cohort comprised 29 patients, with a mean age of 25.3 ± 5.1 years and a mean body mass index of 27.2 ± 2.3 kg/m2. Grade IIb gynecomastia was present in 79.1% and moderate‐to‐severe insulin resistance (HOMA‐IR >3) in 53.7% of patients. ER expression was positive in 100% samples, followed by AR (96.5%), aromatase (96.5%) and PR (93.1%). IGF‐1 was expressed in 86.2% of the cohort, IGF2 in 27.5% and HER‐2 in only two samples, with both showing weak immunoexpression. None of the patients had positive expression of EGFR, TGF‐β or PTHrP. There was no association between immunoexpression and gynecomastia grade. This study demonstrates the predominant role of oestrogen, aromatase and insulin resistance in the aetiopathogenesis of idiopathic gynecomastia and implicates the paracrine hyperestrogenic milieu in its causation as circulating hormones were normal.

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Section: Discussionsupporting

confidence: 92%

The role of steroid receptors, peptides and growth factors in the aetiopathogenesis of idiopathic gynecomastia

et al. 2022

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Body size measurements, digit ratio (2D:4D) and oestrogen and progesterone receptors’ expressions in juvenile gigantomastia

Kasielska‐Trojan

Danilewicz

Sitek

et al. 2020

Journal of Pediatric Endocrinology and Metabolism

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BackgroundJuvenile breast hypertrophy is characterised by massive enlargement of the breast in the peri-pubertal period. We aimed to analyse body size measurements (body mass index [BMI], waist-to-hip circumference ratio [WHR]), digit ratio (ratio of II and IV digits’ length [2D:4D]) and oestrogen receptor (ER) alpha (ERα) and progesterone receptors (PRs) in the breast gland in women with juvenile gigantomastia.MethodsThe study involved 30 women (mean age 25.7 years) (mean age of onset – 14.8 years). ERα and PR expressions were detected immunohistochemically in breast gland samples. For comparison, 100 controls (50 women and 50 men) were included.ResultsBMI and WHR in women with gigantomastia were higher than in control women and the former had a higher WHR than expected for their BMI. 2D:4D in the examined women did not differ from that in control women. However, left 2D:4D was negatively related to the age of gigantomastia onset. There were no correlations between ER and PR expressions and the analysed body and digit ratios.ConclusionsThe lack of a relationship between 2D:4D and juvenile breast hypertrophy may suggest that foetal exposure to sex hormones may not be crucial in its aetiology. However, the link between high left 2D:4D and early development of gigantomastia suggests that prenatal sex hormones have a role in its development timing. High WHR, and particularly high WHR relative to BMI, may indicate that these women had at some stage of development higher circulating androgens, which may have been converted to oestrogens in breasts due to local aromatase activity. Verification of this hypothesis could allow consideration of the role of aromatase inhibitors in juvenile breast hypertrophy.

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Is There a Rationale behind Pharmacotherapy in Idiopathic Gynecomastia?

Cited by 2 publications

References 23 publications

The role of steroid receptors, peptides and growth factors in the aetiopathogenesis of idiopathic gynecomastia

The role of steroid receptors, peptides and growth factors in the aetiopathogenesis of idiopathic gynecomastia

Body size measurements, digit ratio (2D:4D) and oestrogen and progesterone receptors’ expressions in juvenile gigantomastia

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