Is there a psoriasis skin phenotype associated with psoriatic arthritis? Systematic literature review

Abstract

Psoriatic arthritis (PsA) is associated with psoriasis with a prevalence varying from 5.94% to 23.9%. The aim of this study was to assess if some psoriatic skin features are associated with a higher risk of PsA. A systematic literature search was carried out from 1980 to January 2013, in the Embase and Pubmed databases, using a combination of keywords including (Psoriasis) AND (PsA). Of the 2746 articles retrieved, 25 references were selected. Meta-analysis was performed when possible. Mean age at psoriasis onset appeared to be similar among patients with skin disease alone and in those with PsA. There was no clinical type of psoriasis specifically associated with PsA, including pustular psoriasis of palms and soles. Nonetheless specific psoriasis localizations were significantly associated with an increased risk of developing PsA in one cohort study: scalp lesions [Hazard Ratio (HR)

Psoriatic Arthritis and Burden of Disease: Patient Perspectives from the Population-Based Multinational Assessment of Psoriasis and Psoriatic Arthritis (MAPP) Survey

“…Nail involvement typically occurs more often and is more severe in patients with PsA than in those with psoriasis alone and may predict the development of PsA in patients with psoriasis [10,12,16,20,24,30,35].…”

The prognostic value of clinical and anamnestic markers of psoriatic arthritis

“…При ПсА выявлено следующее распределение частоты вовлечения ногтевых пла-стин в патологический процесс: деформация ногте-вых пластин (16,7%), точечные вдавления, так назы-ваемый наперстковый ПС (12,5%), симптом «мас-ляного пятна» (14,6%), сочетанный характер пора-жения (45,8%), отсутствие псориатической онихо-дистрофии (10,4%). Причинно-следственная связь более частого вовлечения в патологический процесс ногтевых пластинок при ПсА может быть обуслов-лена анатомической близостью ногтевого ложа и су-ставных поверхностей, в результате чего происходит распространение воспалительного процесса с одной области на другую [26].…”

Psoriasis inversa

“…Psoriasis der Rima ani ist neben der Kopfhaut-und Nagelbeteiligung einer der 3 Manifestationsorte der Psoriasis, die nachweislich mit einem deutlich erhöhten Risiko für Psoriasisarthritis assoziiert sind [12]. Daher sollte speziell bei Psoriasispatienten, die eine Beteiligung der Rima ani aufweisen, regelmäßig der Gelenkstatus -zumindest orientierend -mit erfasst werden.…”