Is there a prognostic difference between functional and nonfunctional islet cell tumors?

White, Tom J.; Edney, James A.; Thompson, Jon S.; Karrer, F. William; Moor, Burdette J.

doi:10.1016/s0002-9610(05)80134-5

Cited by 60 publications

(25 citation statements)

References 6 publications

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“…There was, however, no significant difference in survival when comparing the two groups. This contrasts with the literature where, generally, non-functioning tumours are considered more aggressive and therefore have a poorer prognosis [17,18,19]. However due to the absence of clinically relevant hormone production, these neoplasm often are confused with pancreatic adenocarcinoma, as was demonstrated in this study where almost 70% of non-functioning tumours were referred with this diagnosis.…”

Section: Discussioncontrasting

confidence: 89%

Neuroendocrine Tumours of the Pancreas: Predictors of Survival after Surgical Treatment

Jarufe

Coldham²,

Oruğ³

et al. 2005

Dig Surg

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Aims: Neuroendocrine tumours of pancreatic and duodenal origin (NETP) are rare and we present a significant experience from a single centre. Methods: Data was collected on 44 patients who underwent surgery between 1988 and 2002. Since 1997, data have been recorded prospectively on a dedicated database. Results: Twenty-four patients had functioning tumours (16 insulinomas, 3 gastrinomas, 2 somatostatinomas, 1 vipoma, 1 glucagonoma and 1 carcinoid tumour). Nine functioning tumours and 13 non-functioning had a malignant phenotype. Twenty pancreaticoduodenectomies, 9 local excisions, 7 distal and 2 total pancreatectomies, 5 bypasses and 1 exploratory laparotomy were performed. Fourteen patients (31.8%) had surgical complications, 1 died peri-operatively (2.3%). The overall actuarial survival for resected cases was 74.4 and 42.5% at 5 and 10 years, respectively. Lymph node invasion and metastases were significant predictors of survival by univariate analysis and only the presence of metastases retained significance on multivariate analysis. Conclusion: Surgical resection is the only curative treatment for NETP. Resection can be safely carried out in a specialist centre and is associated with good long-term survival. The presence of metastases was a significant predictive factor for survival in patients with NEPT in this series.

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Section: Discussioncontrasting

confidence: 89%

Neuroendocrine Tumours of the Pancreas: Predictors of Survival after Surgical Treatment

Jarufe

Coldham²,

Oruğ³

et al. 2005

Dig Surg

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“…Abdominal pain is the major presenting symptom (35–78%), followed by weight loss (20–35%), anorexia and nausea (45%). The patient may present with intra-abdominal hemorrhage (4–20%), jaundice (17–50%) or a palpable mass (7–40%) [21,22,23,24,25]. Fifty-nine percent to 80% of the patients present with synchronous liver metastases at diagnosis [10, 25].…”

Section: Introductionmentioning

confidence: 99%

Well-Differentiated Pancreatic Nonfunctioning Tumors/Carcinoma

et al. 2006

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“…Un estudio comparativo del comportamiento de los tumores funcionantes y de los no funcionantes, no demuestra diferencia significativa en cuanto a incidencia de metástasis, índice de resecabilidad y tiempo de sobrevida libre de enfermedad 4 .…”

Section: All Pancreatic Neuroendocrine Tumors Derive From Langerhans unclassified

Tumores neuroendocrinos del páncreas

Burgos

2004

Rev. méd. Chile

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Is there a prognostic difference between functional and nonfunctional islet cell tumors?

Cited by 60 publications

References 6 publications

Neuroendocrine Tumours of the Pancreas: Predictors of Survival after Surgical Treatment

Neuroendocrine Tumours of the Pancreas: Predictors of Survival after Surgical Treatment

Well-Differentiated Pancreatic Nonfunctioning Tumors/Carcinoma

Tumores neuroendocrinos del páncreas

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