Is there a link between an extremely poor response to ovarian hyperstimulation and early ovarian failure?

Nikolaou, Dimitrios; Lavery, Stuart; Turner, C.; Margara, R.; Trew, Geoffrey

doi:10.1093/humrep/17.4.1106

Cited by 90 publications

(46 citation statements)

References 57 publications

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“…As the number of antral follicles is related to the size of the primordial follicle pool, ovarian response can be regarded as a reflection of ovarian reserve. Recent studies have shown that low response to exogenous gonadotropins' stimulation is associated with early menopause, supporting the idea that ovarian response indeed reflects the ovarian aging process [11]. The excellent correlation between initial AMH levels and subsequent ovarian response in IVF implies that the AMH is a promising marker for ovarian reserve.…”

Section: Discussionmentioning

confidence: 83%

“Anti-Mullerian Hormone: Marker for Ovarian Response in Controlled Ovarian Stimulation for IVF Patients”: A First Pilot Study in the Indian Population

Singh

Malik

Banerjee

et al. 2013

J Obstet Gynecol India

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Objective To measure the levels of early follicular phase Anti-Mullerian hormone (AMH) in Indian patients of IVF and to evaluate the AMH as a predictive marker of ovarian response in assisted reproductive technology outcome. Methods Sixty women (age 25-40 years) selected for in vitro fertilization treatment were included in this study. Analysis of day-2 serum samples was done for the AMH, FSH, Inhibin B, and LH by ELISA kit methods. USG was done for the antral follicle count (AFC) and oocytes' retrieval. Hormone parameters were compared and correlated with the oocytes' retrieval count and the AFC. The discriminant analysis was done to compare relevance of different parameters for predicting ovarian response. Result(s) The Anti-Mullerian hormone showed a significant correlation with the oocytes' retrieval after ovulation induction for IVF (r = 0.648, p \ 0.0001) and no correlation was seen with serum FSH, LH, and Inhibin. Serum AMH levels show 80 % sensitivity and 80 % specificity in predicting poor ovarian response. Conclusion(s) There is a significant correlation between day-2 serum AMH levels and the oocytes' retrieval count in women undergoing ovulation induction for IVF, and the AMH is a good marker as the negative predictive values for the success of ART. There is no correlation found between other hormonal ovarian reserve markers and the oocytes' retrieval count.

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Section: Discussionmentioning

confidence: 83%

“Anti-Mullerian Hormone: Marker for Ovarian Response in Controlled Ovarian Stimulation for IVF Patients”: A First Pilot Study in the Indian Population

Singh

Malik

Banerjee

et al. 2013

J Obstet Gynecol India

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“…This subset of patients, who are young women (<35 years old) within explained infertility, highlights a premature declining ovarian function (PDOF) and they probably represent the "tip of the iceberg" of those women with a premature ovarian aging (POA) who are not identified as being asymptomatic and not desirous to their conception. Moreover, although robust epidemiological data defining a relationship between PDOF-POA and POF are missing, current understanding of premature ovarian senescence suggests that POA may be a milder precursor stage to POF [18][19][20]. Table 1 summarizes the different acronyms referring to the pathology discussed in the present review.…”

Section: Premature Ovarian Failure: the Terminologymentioning

confidence: 99%

Insight into the Genomics of Premature Ovarian Failure

Stigliani¹

2013

J Mol Genet Med

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Primary Ovarian Failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles. It causes infertility in ~1% of women <40 years of age and it has important health consequences for affected patients. POF is a heterogeneous disease, which can develop as a result of a broad variety of pathogenic mechanisms including genetic, autoimmune and iatrogenic causes. However, the mechanisms that cause ovarian dysfunction are poorly understood. Focus on genetic component of the disease has revealed the existence of several causal genetic defects, thus indicating that in addition to some monogenic forms, POF may frequently be a multifactorial disease involving several gene abnormalities and chromosome aberrations. Moreover, most recent studies have highlighted that epigenetic mechanisms may give an additional contribution to POF pathogenesis. This review gives a picture of the state of the art of the complex genetic and epigenetic defects associated with POF, being it clear that a deep comprehension of the molecular etiology of POF may in future early identify those women with higher risk of POF.

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“…These findings are opposite to the results reported in the cow, where the number of growing follicles in response to FSH administration decreased significantly with aging (Malhi et al 2008). In women, there is a lack of systematic research studies and the information has been generated through clinical reports; it is assumed that patients with a poor ovarian response to exogenous gonadotropin treatments are likely to enter the menopause transition sooner and, thus, are in a more advanced phase of the ovarian aging process as compared with patients with a good response (Crosignani et al 2000, De Boer et al 2002, Nikolaou et al 2002, Lawson et al 2003. In this regard, it is believed that the time passing between the detection of the first signs of reproductive aging and the menopause transition is fixed (van Zonneveld et al 2001, te Velde & Pearson 2002.…”

Section: Follicular Function In Aged Ewesmentioning

confidence: 99%

Effect of aging on follicular function may be relieved by exogenous gonadotropin treatment in a sheep model

Berlinguer

González-Bulnes²,

Spezzigu³

et al. 2012

Reproduction

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The current study investigated hormonal and ovarian changes during physiological reproductive aging in Sarda ewes. In a first experiment, follicular and corpus luteum dynamics were compared during an induced oestrus cycle in aged (12-14 years) and young adult ewes (4-5 years). Oestrus cycle characteristics did not differ between the two experimental groups. However, follicular function during the follicular phase showed significant alterations in aged ewes, as determined by a lack of dominance effect and by lower mean values of circulating oestradiol (E 2 ) and inhibin levels, compared with young adult ewes. In a second experiment, differences in follicle growth, hormonal milieu and oocyte quality in response to exogenous FSH administration were assessed in aged and adult ewes. No differences were recorded in ovarian response to FSH treatment between young adult and aged ewes, as evaluated by ultrasonographic data and circulating concentrations of LH, E 2 and inhibin-A. Although the total number of recovered oocytes was similar in the two age groups, the number of good quality oocytes selected for IVM was significantly lower in aged ewes compared with adult ones. Thereafter, no differences were recorded in cleavage rates, total blastocyst output, embryo developmental kinetic and quality between aged and adult groups. In conclusion, this study demonstrated that reproductive aging in sheep is associated with impaired follicle functionality and an increase in the proportion of oocytes showing morphological abnormalities. However interestingly, oocyte developmental competence in vitro and embryo cryotolerance were not affected by the aging process, when only good quality oocytes were chosen.

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Is there a link between an extremely poor response to ovarian hyperstimulation and early ovarian failure?

Abstract: We carried out a controlled retrospective cohort study that showed a strong association between an extremely poor response to ovarian hyperstimulation and early ovarian failure.

Cited by 90 publications

References 57 publications

“Anti-Mullerian Hormone: Marker for Ovarian Response in Controlled Ovarian Stimulation for IVF Patients”: A First Pilot Study in the Indian Population

“Anti-Mullerian Hormone: Marker for Ovarian Response in Controlled Ovarian Stimulation for IVF Patients”: A First Pilot Study in the Indian Population

Insight into the Genomics of Premature Ovarian Failure

Effect of aging on follicular function may be relieved by exogenous gonadotropin treatment in a sheep model

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